All About Vitamins: Vitamin B3 and Metabolic Syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Niacin may be used together with integrated form of exercise in reduced risk and treatment in patients with metabolic syndrome, a 2015 study suggested.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Metabolic Syndrome is a group risk factors used to predict the early onset of cardiovascular diseases and diabetes.

In a total of 20 men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regimen of niacin with niacin doses titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks, showed a significant reduced density lipoprotein particle size by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise.

In comparison to the value following exercise, group treated with combination of exercise and niacin expressed a impressive PON1 activity increase of 6.1% (P = 0.037) and PON1 concentrations increase of 11.3% (P = 0.015) in protection against oxidative damage and lipid peroxidation.

Other in the evaluation of Sixty metabolicsyndrome subjects randomized to 16 weeks of treatment on dual placebo, P-OM3 (4 g/day), ERN (2 g/day), suggested that treated group with niacin and Omega 3 fatty acid (ERN and P-OM3) improved all characteristics of metabolic syndrome;

Subjects treated with combination therapy of (ERN and P-OM3) also showed a rate of improvement of increased HDL cholesterol by 7.8 mg/dl (P = 002) and decreased VLDL(1+2) (-32%; P < 0.0001), and TG by 26 mg/dl (-13%, P = 0.04). with no influence to vascular stiffness.

Taking together, there is no doubt that niacin may be used as therateitic vitamin in reduced risk and treatment of metabolic syndrome, but long tern and large amount intake should only prescribed by your family doctor.

 


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Sources
(1) Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome by Taylor JK, Plaisance EP, Mahurin AJ, Mestek ML, Moncada-Jimenez J, Grandjean PW.(PubMed)
(2) Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial by Shearer GC1, Pottala JV, Hansen SN, Brandenburg V, Harris WS.(PubMed)