Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

Wednesday, August 16, 2017

All About Vitamins: Vitamin B2 Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 as photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation may have a potential efficacy for treatment of breast cancer.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone.

According to the joint study lead by the Moscow Technological University, vitanin B2 induced phototoxicity on human breast adenocarcinoma cells SK-BR-3 with 30 and 60 μM-μM and irradiated with ultraviolet light.

In deed, beside treating breast cancer through photo synthesis, Vitamin B2 and other B vitamin metabolism-important for DNA stability and integrity-may play a role in breast carcinogenesis as breast cancer is associated to levels of plasma folate, riboflavin, vitamin B-6, vitamin B-12, and homocysteine in women.

In a nested case-control study on women aged 35-65 y recruited with a median body mass index of 25.3 kg/m(2) who gave blood samples in 1987-1992 and again in 1993-1998 with breast cancer cases identified by 31 December 2009 individually matched to controls, indicated that breast caner patients is correlated to lower plasma vitamin B-6 and riboflavin.

Dr. Agnoli C, the lead author said, " High plasma riboflavin was associated with significantly lower risk in premenopausal women (RR: 0.45; 95% CI: 0.21, 0.94; highest compared with the lowest quartile, P trend = 0.021). Plasma homocysteine, folate, and vitamin B-12 were not associated with breast cancer risk".

Taking all together, vitamin B2 not only reduced risk of early onset of breast cancer and  can be used as supplement for treatment of breast cancer.

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(1) Riboflavin photoactivation by upconversion nanoparticles for cancer treatment by Khaydukov EV1, Mironova KE1,2, Semchishen VA1, Generalova AN1,2, Nechaev AV1,3, Khochenkov DA1,4, Stepanova EV4, Lebedev OI5, Zvyagin AV1,6, Deyev SM2, Panchenko VY1.(PubMed)
(2) Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese Cohort by Agnoli C1, Grioni S1, Krogh V2, Pala V1, Allione A3, Matullo G3, Di Gaetano C3, Tagliabue G4, Pedraglio S1, Garrone G1, Cancarini I1, Cavalleri A1, Sieri S1.(PubMed)

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