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Thursday, August 24, 2017

All About Vitamins": Vitamin B2 and Gene type Hypertension

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Riboflavin deficiency may be associated to genes implication of hypertension, a recent study suggested.
Hypertension is a condition with abnormal high levels of blood pressure.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

According to the joint study lead by the Ulster University, the discovered by genome-wide association studies have identified many enzymes in a gene which are associated with blood pressure.

In fact, patients with vitamin B2 deficiency induced T polymorphism in MTHFR showed an increased risk of hypertension by 24-87% and CVD by up to 40%, in compared vitamin B2 sufficient people.

In hypertensive patients identified with the MTHFR 677TT genotype, intake of riboflavin supplementation can offer a non-drug treatment to effectively lower blood pressure.

Dr. McNulty H, the lead author in the study said. "riboflavin, targeted at those homozygous for a common polymorphism in MTHFR, may offer a personalized treatment or preventative strategy for hypertension. Further investigations of this novel gene-nutrient interaction in relation to blood pressure, hypertension and hypertension in pregnancy are required".

Other researchers in support of using vitamin B2 supplement of treatment to lowerblood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR) suggested, in the compared group study of a total of 91 in the trial. out of 1427 patients with hypertension, 157 identified with the MTHFR 677TT genotype, riboflavin (1.6 mg/d) treatment group showed a significant lower of systolic BP but less in diastolic BP after 16 weeks in compared at start and the end of treatment and in compared control.

Dr. Wilson CP, the lead researcher said, " A significant improvement in the biomarker status of riboflavin was observed in response to intervention (P<0.001). Correspondingly, an overall treatment effect of 5.6±2.6 mm Hg (P=0.033) in systolic BP was observed, with pre- and postintervention values of 141.8±2.9 and 137.1±3.0 mm Hg (treatment group) and 143.5±3.0 and 144.3±3.1 mm Hg (placebo group), whereas the treatment effect in diastolic BP was not significant (P=0.291).

Taking altogether, riboflavin supplementation may have a potential effect in targeted at hypertensive individuals with the MTHFR 677TT genotype in compared to treatment with current antihypertensive drugs, but treatment offerd to normal hypertensive patients must be taken with great care.

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