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Monday, August 28, 2017

All About Vitamins: Vitamin B3, the Best Vitamin for Longevity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Niacin may be one of the vital vitamin in increased chance of longevity, a renowned study proclaimed.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Georgetown University Medical Center, in the compared efficacy in prolong life span of Zucker Fatty Rats of (ZFR). niacin-bound chromium (NBC) alone and a formula containing other so-called "insulin sensitizers", group treated with NBC showed a significant in increased life span of average (21.8%), median (14.1%), 30th percentile survival (19.6%), and maximum lifespan (22%).

Also, in a total of metabolic parameters of ZFR fed NBC alone (n=12) or NBC in a unique formula of Allium sativum, Momordica charantia, Trigonella foenum-graecum and Gymnema sylvestre and (n=10) to a control group (n=10), Group rats treated with NBC improved circulating glucose levels and ameliorated elevated cholesterol and triglyceride concentrations in compared formula and control. This result suggested that NBC promoted beneficial effects on the glucose and blood pressure systems, which have been factor risks in aging population, effecting longevity.

Other in the study of Nicotinamide, the amide form of niacin (vitamin B(3)), addressed that the vitamin derivative may play a significant role during the enhancement of cell survival as well as cell longevity.

Indeeed, in the experiment model, nicotinamide as a novel agent improved the modulating cellular metabolism, plasticity, longevity, and inflammatory microglial function as well as influencing cellular life span.

Dr. Li F, the lead author in the study said, "The capacity of nicotinamide to govern not only intrinsic cellular integrity, but also extrinsic cellular inflammation rests with the modulation of a host of cellular targets(involved many mechanism)".

Taking altogether, the ability of vitamin B3 and its derivative nicotinamide to foster cellular survival and regulate cellular lifespan in animals should significantly improved the chance in the development of therapies applied to human..

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(1) Niacin-bound chromium increases life span in Zucker Fatty Rats by Preuss HG1, Echard B, Clouatre D, Bagchi D, Perricone NV.(PubMed)
(2) Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide by Li F1, Chong ZZ, Maiese K.(PubMed)

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