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Wednesday, August 30, 2017

All About Vitamins: Vitamin B3 induced Hyperglycemia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Hyperglycemia is a medical condition of abnormal high blood glucose and considered as an early sign of diabetes.

Niacin, one of the antidyslipidemic agent has found to induced blood sugar elevation in patients with diabetes, a renowned institute suggested.

According to the joint study lead by the University of Miami Miller School of Medicine, extended-release niacin (ERN) treatment in patients with/ without high blood cholesterol showed an significant increased fasting glucose from baseline in both those with normal (7.9 ± 15.8 vs 4.3 ± 10.3 mg/dL; P < .001) and impaired fasting glucose (4.1 ± 18.7 vs 1.4 ± 14.9; P < .02) and increased insulin levels.

Rate of risk of the release niacin (ERN) treatment in presumed or confirmed impaired fasting glucose (ERN 197/336) cases (58.6%) are also higher in compared placebo 135/325 cases (41.5%; P < .001) over time.

Furthermore, the evaluation of the effect of [G-protein-coupled receptor, (GPR) 109a] function against islet beta-cell, also indicated the influence of niacin in induced elevated blood glucose concentration in obese mice observed by oral glucose and intraperitoneal insulin tolerance tests, promoted pancreatic islet dysfunction through free radicals expression in interaction with the the islet beta-cell.

Additionally, Dr.Bays HE, the lead author at the joint study lead by the Louisville Metabolic & Atherosclerosis Research, in the review of the literature of clinical trial data from patients with T2DM, randomized 4:3 to double-blind Extended-release niacin/laropiprant (ERN/LRPT) or placebo (n=796), said, "12 of treatment, ERN/LRPT significantly improved low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol, triglycerides, and lipoprotein (a), compared with placebo, with equal efficacy in patients above or below median baseline glycemic control. Compared with placebo, over 36 weeks of treatment more patients treated with ERN/LRPT had worsening of their diabetes and required intensification of antihyperglycemic medication, irrespective of baseline glycemic control. Incidences of other adverse experiences were generally low in all treatment groups".

Yes, niacin treatment modifies the lipid-effects with increased baseline glycemic control in patients with T2DM.

Patient who take supplement niacin to lower high blood cholesterol should also modify the glucose levels to prevent the risk of glucose spike inducing pre diabetes.

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(1) Effects of Extended-Release Niacin Added to Simvastatin/Ezetimibe on Glucose and Insulin Values in AIM-HIGH by Goldberg RB1, Bittner VA2, Dunbar RL3, Fleg JL4, Grunberger G5, Guyton JR6, Leiter LA7, McBride R8, Robinson JG9, Simmons DL10, Wysham C11, Xu P12, Boden WE13.(PubMed)
(2) Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets by Chen L1, So WY1, Li SY1, Cheng Q1, Boucher BJ2, Leung PS3.(PubMed)
(3) Extended-release niacin/laropiprant significantly improves lipid levels in type 2 diabetes mellitus irrespective of baseline glycemic control by Bays HE1, Brinton EA2, Triscari J3, Chen E3, Maccubbin D3, MacLean AA3, Gibson KL3, Ruck RA3, Johnson-Levonas AO3, O'Neill EA3, Mitchel YB3(PubMed)

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