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Monday, August 14, 2017

All About Vitamins: Vitamin B2 Improved Metabolism by Reduced Urinary Dicarboxylic Acids in Autism

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Riboflavin may have a potential effect in children with autism used conjunction with other B vitamin, a recent study suggested by a renowned institute.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Autism is one of the most common forms of brain development disorder and one in 166 child is diagnosed with some forms of autism with weak immune system and auto immune problems.

Children with autism is found to associate to dietary intake of deficiency micronutrients (traditional Mediterranean diet) of dairy and cereal products, and less iodine, sodium, and calcium than their typically developing peers.

According to the University of Valencia, children with autism tended to eating selectively with dietary failed to meet dietary recommendations for thiamin, riboflavin, vitamin C, or calcium... as well as fiber, vitamin E, and sodium.

Dr. Marí-Bauset S, the lead author said, " Results suggest that (1) risk of inadequate intake of some micronutrients in children with autism spectrum disorder and (2) cultural patterns and environment may influence food intake and anthropometric characteristics in autism spectrum disorder".

In the investigation of the potential problems especially connected with energy production, intestinal dysbiosis, and nutritional individuality in autistic children, researchers found that increased urinary dicarboxylic acids showed an important role in reduced nutritional metabolism.
And oral administration of supplements including vitamin B2 ameliorated the production of level of dicarboxylic acids in the urine of autistic children.

The study also indicated before treatment with vitamin B2, levels of succinic, adipic, and suberic acids in the urine of autistic children were 41.47 ± 50.40 μmol/mmol creatinine, 15.61 ± 15.31 μmol/mmol creatinine, 8.02 ± 6.08 μmol/mmol creatinine, but after supplementation, the levels were 9.90 ± 8.26 μmol/mmol creatinine, 2.92 ± 2.41 μmol/mmol creatinine, and 2.57 ± 3.53 μmol/mmol creatinine,

This result demonstrated the efficacy of vitamin B2 in attenuated the levels of urinary dicarboxylic acids in induced symptoms of autism.

Taking together, intake Vitamin B2 combined with other micro nutrients are effective to improve dietary metabolism through ettentiating the levels of Dicarboxylic Acids in Autism.


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Sources
(1) Comparison of nutritional status between children with autism spectrum disorder and typically developing children in the Mediterranean Region (Valencia, Spain) nu Marí-Bauset S1,2, Llopis-González A1,2,3, Zazpe I4,5, Marí-Sanchis A6, Morales Suárez-Varela M1,2,3.(PubMed)
(2) B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children by Kałużna-Czaplińska J1, Socha E, Rynkowski J.(PubMed)

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