All About Vitamins: Vitamin B2 in Inflammatory Response

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin B2 may process a potency in reducing obesity-related inflammation, the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Inflammation is a natural expression by immune system in induction of while blood cells for protection our body against infection with foreign organisms and injure.

According to the joint study lead by the Jagiellonian University Medical College, pretreatment with a low dose of riboflavin (10.4-1000 nM) following with lipopolysaccharide stimulation (LPS; 100 ng/mL) affected the pro-inflammatory activity through reduced obesity-related inflammation.

Dr. Mazur-Bialy AI, the lead author said, " riboflavin effectively inhibits the pro-inflammatory activity of adipocyte, the lipocytes and fat cells in stored fat and macrophage in induced against imuune abnormal response to allergens.

Furthermore, riboflavin deficiency is also shown to associate to obese subject induced over expression of pathological pro-inflammatory response of macrophages, the main component of adipose tissues.

In the study of mouse 3T3 L1 preadipocytes differentiated to adipocyte and culture in the state of riboflavindeficiency (3.1nM) or control condition (10.4nM), treatment of riboflavin. reduced a significant elevation in adipocyte lipolysis and obesity-related apoptosis of adipocytes.

The study also found that riboflavin treatment not only decreased the generation of reactive oxygen species by 43% but also inhibited the production of inflammatory cytokins, in riboflavin-deficient subject.

Taking together, obese patients with induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation probably involved many mechanisms, including vitamin B2 deficiency.

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Sources
(1) Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development by Mazur-Bialy AI1, Pocheć E2.(PubMed)
(2) Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development by Mazur-Bialy AI1, Pocheć E2.(PubMed)