All About Vitamins: Vitamin B3 and Cardiovascular Disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Cardiovascular disease is conditions involved narrowed or blocked blood vessels cause of heart attack.
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered as a therapeutic vitamin in reduced risk and treatment of heart disease.

According to the University of Texas Southwestern, intake of niacin, not only showed to raise HDL-C, increases HDL-C by up to 25 % but also reduced risk of cardiovascular diseases.

More importantly, the study stressed that the influence of HDL function-related measures may be better targets for CV risk reduction, instead of the importance of HDL-C modulation on CV risk.

Others in the review of several large trials and meta-analyses of the effects of lipid-lowering statin therapy, insisted that statin therapy showed an consistent demonstration in significantly reduced LDL-C levels and incidence of cardiovascular events.

Dr. Cziraky MJ, the lead author said, "As monotherapy agents, fibrates and niacin have been demonstrated to alter several lipid parameters and reduce cardiovascular events. Niacin appears to exert the greatest beneficial effects on the widest range of lipoprotein abnormalities, in addition to possessing an established safety profile" and "niacin/statin combination therapy may provide greater benefits, as manifested through a correction of atherogenic lipid abnormalities, a slowing of atherosclerosis progression in coronary heart disease (CHD) patients, and a reduction of residual cardiovascular risk".

The study also illustrated that combination of niacin, fiber and stain may be considered as one most effective treatment in reduced risk and treatment of high blood cholesterol and cardiovascular events with cost-effective achievement of optimal lipid values (OLVs) in several at-risk patient populations.

Taking altogether, niacin may be combined with other therapeutic substances for improved treatment of heart diseases through its contribution in reduced blood cholesterol abnormality.

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Sources
(1) Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?by Mani P1, Rohatgi A.(PubMed)
(2) Targeting low HDL-cholesterol to decrease residual cardiovascular risk in the managed care setting by Cziraky MJ1, Watson KE, Talbert RL(PubMed)