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Tuesday, September 19, 2017

All about Vitamins: Niacin, A dietary Supplement for Enhanced Immunity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be a potential agent in promoted immune response against invasion of micro bacterial invasion. a renowned institute suggested.

Immune responses is a normal reaction of immune system in prevented infection and inflammation caused by foreign invasion, and further injure and damage due to wound of body tissues and organs.

According to the study of 30% of HIV-1-infected patients receiving antiretroviral therapy in reduced elevated risk for clinical progression to AIDS and non-AIDS events, involving CD4+ T-cell depletion, extended-release form of niacin (Niaspan FCT™) in combination with antiretroviral therapy, showed a significant effect in improved immune activation, thus increasing CD4 recovery in compared to deferred use of Niaspan patients after 24 week periods.

Apparently, niacin expressed a strong expression pf suboptimal immune responses, through its impact of on neurocognitive function in HIV-infected individuals.

Dr. Lebouché B, the lead author said, " Niacin (vitamin B3) is able to control the excess tryptophan oxidation, correcting tryptophan depletion, and therefore represents an interesting strategy to improve CD4 recovery".

Niacin, in other study, with direct action in regulation of inflammatory responses or disordered immune mechanisms may be considered as a supplementary therapy in rheumatic diseases, atopic disorders and chronic infections. 

In order to achieve a optimal effect of niacin as immunostimulating therapy, other micro and marco nutrients such as suboptimal levels of EFAs, vitamins and trace elements should always be taken into account, the study also suggested.

More importantly, NAD in synthesis of mono ADP-ribose, expressed a significant involvement in signal transduction. as the vitamin showed to important function in mediation of two intracellular calcium signaling pathways to enhance immunity against cancer cell division through improved genomic stability.

Dr. Kirkland JB, said, " niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations".

Taking together, niacin as a dietary supplement may have a potential effect in reduced risk of any form disease involving action of  immune system.

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(1) The role of extended-release niacin on immune activation and neurocognition in HIV-infected patients treated with antiretroviral therapy - CTN PT006: study protocol for a randomized controlled trial by Lebouché B1, Jenabian MA, Singer J, Graziani GM, Engler K, Trottier B, Thomas R, Brouillette MJ, Routy JP.(PubMed)
(2) Specific application of single nutrients as a basic treatment in immunostimulating therapy by Reinhold U.(PubMed)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

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