All About Vitamins: Vitamin B3 deficiency induced Dementia in Pellagra Patients

By Kyle J. Norton.

Vitamin B3 deficiency may be associated to the early onset and progressive risk of dementia in patients with pellagra, a respectable institute proposed.

 Dementia, the neurodegenerative diseases characterized by the loss of mental ability severe enough to interfere with people's every life. Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Pellagra is a nutritional deficiency of tryptophan and niacin (nicotinic acid) disease

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Kyoto University Graduate School of Medicine, dementia induced by patients with Pellagra, a photosensitivity syndrome postulated an exhibition of reactive oxygen species(ROS) production through increased levels of hormone prostaglandin E₂.

In niacin deficient mice model of pellagra, mice showed a significantly elevated inflammatory expression levels of COX-2, and PGE syntheses, in induced risk dementia.

In a case reported by the Anning Hospital, male with a classic case of pellagra bought to the hospital was found to process disorderly behavior induced cardinal symptoms of dermatitis, dementia caused by niacin deficiency.

The patients made a complete recovery after 6 months of appropriated treatment including supplement of niacin.

Additionally, in a case-control study of compared the past dietary habits of 342 Parkinson's disease (PD) patients recruited from nine German clinics with those of 342 controls from the same neighborhood or region, niacin intake through supplement or high niacincontent in coffee and alcoholic beverages, are found to have a inversely associated with PD.

The findings suggested that niacin plays a important role in reduced risks of pellagra expression of dementia and Pakistan disease.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production by Sugita K1, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K.(PubMed)
(2) Case report of mental disorder induced by niacin deficiency by Wang W1, Liang B1.(PubMed)
(3) Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study by Hellenbrand W1, Boeing H, Robra BP, Seidler A, Vieregge P, Nischan P, Joerg J, Oertel WH, Schneider E, Ulm G.(PubMed)