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Thursday, September 21, 2017

All About Vitamins: Niacin in reduced Risk of High Levels of Phosphorus in Kidney Diseases

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered a dietary supplement in reduced risk and progression of kidney diseases, a renowned institute study suggested.

Kidney diseases are medical condition characterized by impairment of kidney function in filter metabolic wastes from the blood.

According to the University of Karachi, niancin treatment over 4 months, showed a significant effect in reduced risk dyslipidemia and phosphorus level, in compared to control group treated with statin.
in a study of chronic kidney disease patients fulfilling the pre-defined criteria and randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or NER 500 mg/day with the same dose of statin.

In compared to conventional medicine atorvastatin, niacin extended release (NER) scored a significant result in decreased levels of phosphorus than atorvastatin, used as lone treatment.

Dr. Yasmeen G, the lead researcher said," its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction.".

Instantly, in the post hoc data analysis of serum phosphorus concentrations among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268). only one of daily treatment of ERN-L  expressed a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline in compared to other groups.

Further more, the testing of extended release niacin (ERN) alone and ERN combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (ERN-L), treatment of extended release niacin (ERN) also showed a same effect in reduced serum FGF23 concentration in compared to 2 other groups, with equivalent declines in serum phosphorus in (ERN-L) group but not in placebo group.

Taking altogether, there is no doubt that niacin under the form extended release niacin (ERN) may have a potential used conjunction of with conventional medicine in reduced complications of kidney diseases caused high levels of phosphorus.

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(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)
(3) Effect of niacin on FGF23 concentration in chronic kidney disease by Rao M1, Steffes M, Bostom A, Ix JH.(PubMed)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

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