All About Vitamins: Niacin on Obesity and Obese Toxicity

By Kyle J. Norton.

Chronic niacin and vitamins overload may induce risk of obesity and obese toxicity, a renowned institute study suggested.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Dalian University, co-administration of glucose and 300 mg nicotinamide in animal study showed a significant elevated levels of RSO and insulin levels but the 3-h blood glucose test showed the levels of was significantly lower.

The study result indicated that niacin not only has an appetite-stimulating effect involved oxidative stress but also be concerned as a major factor in the increased obesity prevalence in US children with excess consumption.

Dr.Li D, the lead author said, "The obesity prevalence among American children increased with the increasing per capita niacin consumption, the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat cereal consumption, with a 10-year lag".

Furthermore, in other same subject study conducted by the same university, intake of excess amount of vitamin supplement and fortify food have found to accompany by an increased prevalence of obesity, a condition associated with diabetes, hypertension, cardiovascular disease, asthma and cancer.

Recent experiment also suggested that not only excess niacin showed to induced obesity, obese patients also exhibited low fasting serum but high erythrocyte folate concentrations, exhibiting folate oxidation involved oxidative stress. 

Dr. Zhou SS, the lead author said, "here is also evidence that obesityincreases niacin degradation, manifested by increased activity/expression of niacin-degrading enzymes and high levels of niacin metabolites" and " that low fasting serum vitamin status in obesity may be a compensatory response to chronic excess vitamin intake, rather than vitamin deficiency, and that obesity could be one of the manifestations of chronic vitamin poisoning".

The finding evidenced proposed that excess vitamins intake may have a potential toxic effect in obese patients.

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Sources
(1) Chronic niacin overload may be involved in the increased prevalence of obesity in US children by Li D1, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.