All About Vitamins: Niacin and Schizophrenia

By Kyle J. Norton.

Niacin sensitivity and response may be associated to the developed schizophrenia, a renowned institute study suggested.
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Schizophrenia is a mental condition characterized by failure between thought, emotion, and behavior affecting patient ability in differentiated perception, appropriate actions and feelings......

 Schizophrenia patients showed a diminished neither sensitivity nor efficacy of niacin correlated with AA levels, in constrast to a significant correlation between AA levels and niacin sensitivity in control group according to the study of injection of eight concentrations of methylnicotinate to the forearms of 20 adults with schizophrenia and 20 controls,

The study also addressed that the levels of adrenic acid showed a strong correlated with niacin efficacy in schizophrenia patients and the correlation between adrenic acid and niacin efficacy in schizophrenia indicated other mechanism, such as expression of n-6 PUFA may involve to the blunted niacin response.

Dr. Messamore E, the lea author said, "The schizophrenia-associated niacin response abnormality involves both diminished sensitivity and reduced efficacy. The lack of expected correlation between levels of AA and adrenic acid suggests homeostatic imbalance within the n-6 polyunsaturated fatty acid (PUFA) pathway in schizophrenia".

Additionally, in the study of normal skin flush response, niacin attenuated in many individuals with schizophrenia (SCZ), showed an abnormal response to niacin, in inducing abnormal prostaglandin signaling due to depletion of AA, and other essential fatty acids (EFAs).

Other researchers insisted that the abnormal of niacin response of schizophrenia may also be associated to larger machenisms, including abnormalities in enzymes, receptors, or signal transduction mechanisms that affect the synthesis, release, or response to vasodilatory prostaglandins.

Taking together, there is no doubt that patient with schizophrenia is associated to niacin abnormal response and sensitive involved expression of many effects.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Niacin sensitivity and the arachidonic acid pathway in schizophrenia by Messamore E1, Hoffman WF, Yao JK.(PubMed)
(2) The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study by Messamore E1, Hoffman WF, Janowsky A.(PubMed)