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Friday, September 22, 2017

All About Vitamins: Niacin Lowers Hypercholesterol and risk of CVD in Diabetic patients

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may have a potential in reduced risk of hypercholesterol and cardiovascular disease in patients with diabetes, a Medical institute suggested.

According to the School of Medicine and Pharmacology, niacin exhibited HDL metabolism in reduced all forms of bad cholesterol and increased good cholesterol level in patients with type 2 diabetes.

In a total of 12 men with type 2 diabetes mellitus recruited for a randomized, crossover design trial, patients randomized to rosuvastatin or rosuvastatin plus ER niacin for 12 weeks and then crossed over to the alternate therapy after a 3-week washout period, metabolic assay showed that extended-release (ER) niacin treatment significantly decreased plasma triglyceride, plasma cholesterol, non-HDL cholesterol, low-density lipoprotein cholesterol, articular in HDL cholesterol in compared to other groups.

Dr. the lead researcher said, " ER niacin increases HDL apoA-I concentration in statin-treated subjects with type 2 diabetes mellitus by lowering apoA-I(in measurement of cardiovascular risk) fractional catabolic rate".

In the same same group of patients with type 2 diabestes, in compared the effective of rosuvastatin or rosuvastatin plus ER niacin, extended-release (ER) niacin on apolipoprotein B-48 (apoB-48) kinetics in statin-treated treatment also showed a reduction of level of apoB-48 concentration, but significant lower than group treated with conventional treatment.

The study also emphasized that the ER niacin exhibition of reduced cardiovascular risk showed independent to the levels of triglyceride, according to testing assay.

In fact, the efficacy of ER in reduced risk of CVD may be resulted of reduction of apoB-48 concentration through lowering fasting and postprandial apoB-48 secretion rate.

Taking together, niacin injection may have a profound effect in treating diabetic patients in ameliorated risk of CVD through expression of lower level of total blood cholesterol.




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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of niacin on high-density lipoprotein apolipoprotein A-I kinetics in statin-treated patients with type 2 diabetes mellitus by Pang J1, Chan DC, Hamilton SJ, Tenneti VS, Watts GF, Barrett PH.(PubMed)
(2) Effect of niacin on triglyceride-rich lipoprotein apolipoprotein B-48 kinetics in statin-treated patients with type 2 diabetes by Pang J1, Chan DC1, Hamilton SJ1,2, Tenneti VS1, Watts GF1, Barrett PH1,3.(PubMed)

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