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Friday, September 15, 2017

All About Vitamins: Niacin reduced risk of co-morbidities in patient with chronic kidney disease.

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Kidney disease is a medical condition of kidney impairment, characterized by adequately filter metabolic wastes from the blood.

Niacin may have a potential effect as phosphorus lowering agents in patient with ischemic nephropathy, inducingvarious types of syndromes and diseases,  a joint study suggested.

According to the University of Karachi, Karachi, niacin may be one of low cost supplement used management effectively in attenuated elevated serum phosphorus in patient population with compromised kidney performance. Thus reducing co-morbidities especially cardiovascular disease risk and derangement in calcium-phosphorus homeostasis in advancing to onset of chronic kidney disease.

In the study of 170 chronic kidney disease patients and 50 healthy control, fulfilling the pre-defined criteria, randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or extended release niacin(NER) 500 mg/day with the same dose of statin for four months, injection of atorvastatin alone and NER showed a significantly reduced phosphorus level.

In compared to the adverse effect in both treatments, the university also said, "NER, at its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction".

Furthermore, in data analysis of serum phosphorus concentrations, among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268), repeated measurement of ERN-L treatment resulted in lowering serum phosphorus change comparing ERN-L with placebo.

Dr. Maccubbin D, the lead author siaid, "once-daily ERN-L treatment causes a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline".

Taking together, niacin may be effective for enhanced kidney function by reduced level of phosphorus in both healthy and chronic kidney disease patients. intake of large amount should be taken with care under close observation by medical professional.

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Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)

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