Broccoli and Tomato Inhibits Elevated Hormone Resistin Associated with Insulin Resistance

Insulin resistance is a hallmark of type 2 diabetes characterized by the inability of the body to use the insulin produced by the pancreas properly.

In other words, signals sent out by the hormone insulin caused by clog-up of the insulin receptors was ignored by the cell of the muscles, body fat, and liver that process the function to convert glucose into energy.

More precisely, as the clogged up insulin receptors that ignore the signals of the hormone insulin, insulin resistance develops, leading to more production of insulin by the beta cells and over time causing permanent damage to the cells in the pancreas.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.


A 2016 joint study led by the MSA University, suggested that tomato and broccoli extract effects on glucose homeostasis in high fat diet-induced obesity in rats by regulating the adipocyte hormone Resistin.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.


Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose
and often in the greenhouse.
According to the US statistics, approximately, 60 to 70 million individuals are affected by insulin resistance with 40% of individuals older than 50 years may be at risk of insulin resistance.

Believe it or not, the most common risk factors associated with insulin resistance are obesity and hypertension associated with the promotion of a high-fat diet over the past few decades.

Dr. Merat S, the lead scientist wrote, " Contrary to expectation, IR was induced in mice fed the Western diet,,,. The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".


A total of 48 male albino rats included in the study were divided into 8 groups as follows: control, HFD, stop fat diet (SD), Tomato 200 mg/kg (T200), Tomato 400 mg/kg (T400), Broccoli 200 mg/kg (B200), Broccoli 400 mg/kg (B400), and Chromax (CX).

According to the tested differentiation after 1 month of treatment,
* Serum levels of resistin were significantly reduced in all groups treated with tomato, broccoli, and CXIn other words, T 200, T 400, B 200, B 400 and CX groups reduced levels of resistin to: 4.13 ± 0.22 ng/ml, 1.51 ± 0.04 ng/ml, 4.13 ± 0.22 ng/ml, 2.32 ± 0.15 ng/ml and 1.37 ± 0.03 ng/ml, compared to the baseline, respectively.

Where resistin is an adipocyte hormone associated with regulating glucose metabolism. Elevated levels of resistin have been found to cause insulin resistance in diabetics.

Increased levels of serum levels of leptin were significantly reduced anti-elevated levels of resistin in the T 400 group compared to the B 400 and CX groups.

Additionally, serum levels of adiponectin associated with the insulin resistance were significantly increased in the T 400 group (131 ± 3.84 pg/ml).

The results strongly suggested that broccoli and tomato extract inhibited the elevated levels of hormone resistin that cause insulin resistance in the high-fat-diet-induced diabetes animal model.

Based on the finding, researchers said, " tomato and broccoli extract treatment regulates glucose homeostasis via reduction of serum resistin and may be a useful non-pharmacological therapy for obesity".

Taken altogether, broccoli and tomato extract may be considered supplements for the prevention and treatment of insulin resistance, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Resistin mediates tomato and broccoli extract effects on glucose homeostasis in high fat diet-induced obesity in rats by Aborehab NM1, El Bishbishy MH2, Waly NE. (PubMed)
(2) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)