Caffeine Expressed Gene Alternation and Medicine Interaction

Compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address the cause of disease.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee may have a profound effect in the risk of certain disease induced by DNA methylation, a renowned study suggested.

In a study to differentiate genome-wide DNA methylation for coffee and tea consumption in four European cohorts (N = 3,096) with DNA methylation measured from whole blood at 421,695 CpG sites distributed throughout the genome and analysed in men and women both separately and together in each cohort, researchers at the joint study lead by the Science for Life Laboratory, found that No individual sites were found to associate with men or with the sex-combined analysis for coffee.

Contrastively, in the re-examine of two placebo-controlled studies, among subjects taking creatine, for whom higher caffeine intake was associated with more rapid progression of PD, according to the DNA samples and caffeine intake data.

Although GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group, intake of coffee may have interacted with creatine in many different ways in these group of patients, particularly in the creatine group with high levels of caffeine intake,

These result indicated an important results
1. Coffee and caffeine intake do not exert change of DNA in healthy individuals.
2. Caffeine exposed a strong interaction with some medication, such as creatine to induce DNA change
3. These inactions increased the severity of the disease expression and progression


Dr. Simon DK, the lead author said, "(the study demonstrated an example of) a genetic factor interacting with environmental factors illustrates the complexity of gene-environment interactions in the progression of PD.


In support of the above analysis, Dr. Yamada-Fowler N, the lead researchers of another joint study lead by the Linköping University, insisted that caffeine expresses a strong effect in increased risk PD progression by interaction with gene GRIN2A, instead of the group with the intake of creatine

The findings suggested that caffeine may have a profound effect in interaction with some medication in induced some genes change or induce DNA change without the presence of medicine intake in some diseases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tea and coffee consumption in relation to DNA methylation in four European cohorts by Ek WE1, Tobi EW2, Ahsan M1, Lampa E3, Ponzi E4,5, Kyrtopoulos SA6, Georgiadis P6, Lumey LH7, Heijmans BT8, Botsivali M6, Bergdahl IA9, Karlsson T1, Rask-Andersen M1, Palli D10, Ingelsson E11,12, Hedman ÅK12, Nilsson LM13, Vineis P14, Lind L15, Flanagan JM16, Johansson Å1; Epigenome-Wide Association Study Consortium(PubMed)
(2) Caffeine, creatine, GRIN2A and Parkinson's disease progression by Simon DK1, Wu C2, Tilley BC3, Lohmann K4, Klein C5, Payami H6, Wills AM7, Aminoff MJ8, Bainbridge J9, Dewey R10, Hauser RA11, Schaake S12, Schneider JS13, Sharma S14, Singer C15, Tanner CM16, Truong D17, Wei P18, Wong PS19, Yang T20.(PubMed)
(3) Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population by Yamada-Fowler N1, Fredrikson M2, Söderkvist P1.(PubMed)