Phytochemical Lycopene Inhibits the Risk of Coronary Artery Disease in Men

Coronary artery disease (CAD)is a medical condition caused by the damage of major blood vessels that supply the heart with blood, oxygen, and nutrients (coronary).

The acute coronary syndrome is a medical emergency caused by suddenly reduced blood flow to the heart, leading to heart muscle damage and brain apoptosis, depending on the affected location.

An acute coronary syndrome is associated with the severity of buildup of plaque deposits on the walls of the coronary arteries.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.

Most cases of coronary artery disease onset are associated with inflammation of cholesterol-containing plaques in the arteries.

According to the statistics, approximately 1 of every 13 Americans aged 18 years and older are living with coronary artery disease. CAD is a leading cause of death in the ethnic group in the US, particularly in Hispanic American.

Believe it or not, CAD is predicted by scientists to become the most common cause of death worldwide by 2020.

Although CAD is a lowly progressive disease, the disease may become clinically apparent by age 40. People 65 years of age and older have been found in most patients with CAD.

Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of coronary artery disease, chest pain or discomfort, pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.

If the chest pain is persistent with no sign of stopping, please call 911 immediately.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the treatment of cardiovascular diseases (CVD), researchers examined the role of lycopene on acute coronary events and stroke in the prospective Kuopio Ischemic Heart Disease Risk Factor (KIHD) Study that included 725 middle-aged men free of coronary heart disease and stroke.

According to the tested analysis, men with the lowest quartile of serum levels of lycopene had a 3.3-fold (P < 0.001) risk of the acute coronary event or stroke as compared with others.

Also in men, low plasma levels of lycopene were associated with an 18% increase of intima-media thickness (IMT) associated with plaque accumulation compared to men with higher plasma levels of lycopene.

However, In women, there was no significantly different after the adjustments.

The results strongly suggested that the circulating levels of lycopene have a strong effect on the risk of cardiovascular disease in Finland, at least in men.


Based on the findings, researchers said, "circulating levels of lycopene, a biomarker of tomato-rich food, may play a role in early stages of atherogenesis and may have clinical and public health relevance".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of coronary artery disease, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene, atherosclerosis, and coronary heart disease by Rissanen T1, Voutilainen S, Nyyssönen K, Salonen JT. (PubMed)
(2) Coronary Artery Disease (CAD) by Continuing Education for Health Professionals