Herbal Bilberry, the Natural Treatment for Chronic Venous Insufficiency (CVI) with No Side Effects

Chronic venous insufficiency (CVI) is a condition caused by the interruption of blood that returns to the heart from the legs due to the damage of venous wall and/or valves in the leg veins, leading to the collection of blood on the veins.

The pool of blood that collected into the veins is called stasis which can be observed over the surface of the affected area.

Researchers do not know the exact causes that prevent the valves to block the calf muscles and the muscles in the feet to squeeze the veins and push the blood upward. However, according to epidemiological studies, researchers do know that aging, occupation associated with extended sitting or standing or a combination of aging and reduced mobility are some of the most prevalent factors associated with chronic venous insufficiency.

Deep vein thrombosis (DVT), a condition of a blood clot that formed in a vein deep in the leg has been found to develop CVI within 10 years after diagnosis in over 30% of patients.

The University of California in the examination of the risk factors associated with chronic venous insufficiency (CVI) by classified them against the gender suggested age, family history of venous disease, waist circumference, and flat feet were most common predictive risks in both sexes.

However, men with occupation as a laborer, cigarette smoking, and normotension were also independently associated with severe venous disease.

In women, hours standing, history of a leg injury, number of births, and cardiovascular disease have also increased the risk of the condition.

Most common symptoms of CVI include swelling, pain, itchiness and twisted, enlarged veins observed on the skin on the affected location.

Untreated CVI may cause increased pressure and swelling that have been found to burst the capillaries, leading to skin reddish-brown, especially near the ankles.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to discover a novel and natural ingredient for the treatment of chronic venous insufficiency with no side effects, researchers examined the effects of an oral venotropic compound (Linfavenix, including bilberry) on patients with chronic venous insufficiency (CVI).

Patients selected to the study were divided into a group treated with Linfavenix or with below-knee elastic compression.

According to based results, the Linfavenix group included 14 patients 7 males and 7 females with the mean age of 44.5 exerted the average ambulatory venous pressure (AVP) range 34-55 compared to those in the elastic compression group with 12 patients (5 males and 7 females) with the mean age of 45 of the range of 36-56.

In other words, there were no significant differences in AVP and RT between the two groups in the improvement of chronic venous insufficiency (CVI) at the treatment of 2 weeks.


However, at 4 weeks although there were nonsignificant between the two groups, RF in the Linfavenix group showed a significant decrease in chronic venous insufficiency (CVI) compared to the efficacy in a single ingredient treatment.


The findings suggested that the treatment with Linfavenix is effective for the treatment of CVI at least comparable to those of elastic compression but in a lesser extent compared to the combined treatment.

During the experiment, no adverse effects were reported by the participants. According to the compliance and tolerability scores, no patient had to stop treatment; there were no drop-outs.

Based on these results, researchers suggested, "the treatment with Linfavenix is, in its microcirculatory efficacy, at least comparable than elastic compression with is considered a standard therapeutic option in these patients".

Taken altogether, bilberry used combined with other ingredients may be considered a functioning remedy for the treatment of chronic venous insufficiency (CVI) pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) LINFAVENIX: improvement of signs and symptoms of chronic venous insufficiency and microangiopathy by Cesarone MR1, Belcaro G, Grossi MG, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Cacchio M. (PubMed)
(2) Risk Factors for Chronic Venous Disease: the San Diego Population Study by Michael H. Criqui, MD, MPH,1,2 Julie O. Denenberg, MA,1 John Bergan, MD,3Robert D. Langer, MD, MPH,5 and Arnost Fronek, MD, PhD. (PMC)