Curcumin, the Single Bioactive Compound Which Processes Cardioprotective Property Against Heart Disease, Scientists Say

Scientists may have found a kitchen bioactive compound which processes cardio-protective properties, according to studies.

Cardioprotection is an action that contributes to the protection of heart integrity against damage or injury.

In other words, cardioprotection is a process in which substances or medicines are used including an herbal remedy to protect heart muscle tissues against ischemic insult and deoxygenation injury.

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart.

Coronary artery disease caused by narrowing of the arteries, heart attack, abnormal heart rhythms, or arrhythmias and stroke are the most common types of cardiovascular diseases found in the Western world.

Most common symptoms of CVD include persistent fatigue, shortness of breath, irregular heartbeat, chest pain, and fainting.

If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the CVD possibility.

The exact causes of cardiovascular diseases are unidentified. However, according to epidemiological studies, the most prevalent factors include aging, smoking. lack of exercise. unhealthy diet. obesity. high blood pressure and cholesterol, and family history.

Out of many risk factors, an unhealthy lifestyle is one of the major risk factors that cause the onset of CVD, some researchers suggested.

Dr. Haskell WL in the investigation of cardiovascular disease prevention and lifestyle interventions
said, "While heredity can be a major factor for some people, their personal health habits and environmental/cultural exposure are more important factors".

And, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program. For people at high risk of CVD, medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia. Maintaining an effective CVD prevention program in technologically advanced societies cannot be achieved by many high-risk persons without effective and sustained support from a well-organized health care system".

The results strongly suggested by lifestyle change has a strong implication in the prevention of the CVD.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potent compound which processes cardioprotective effects, researchers investigated the cardioprotective effect of curcumin in NE-induced cardiac apoptosis according to the tested assays, curcumin protected the cardiomyocytes against apoptosis significantly.

Furthermore, injection of curcumin also reverted to cardiomyocytes damage back to the normal physiological state.

In other words, curcumin protected the integrity of heart muscle cells against Norepinephrine (NE) in the induction of the onset of cardiomyopathy and heart failure.


Dr. Manghani C, the lead scientist said, "curcumin has the potential to act as a therapeutic agent for the attenuation of NE-induced cardiac cell death and modulation of apoptosis in H9c2 cardiomyocytes".

Taken altogether, turmeric may be considered a cardioprotective supplement for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cardioprotective potential of curcumin against norepinephrine-induced cell death: a microscopic study by Manghani C1, Gupta A1, Tripathi V1, Rani V. (PubMed)
(2) Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection by Hernández M1, Wicz S1, Corral RS. (PubMed)
(3) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)