Lycopene Processes A Strong Cardio Protective Activity

Cardiovascular disease is a class of condition associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of heart and blood vessels.

Cardio-protection is a process to preserve the function and integrity of the cardiac muscle cell.
In other words, cardio-protection is an action that protects heart muscle against damage, including the use of herbal medicine.

Cardiotoxicity induced by toxins reduced the heart pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs. Most common causes of cardiotoxicity are associated with patients who received chemotherapy and certain medications.

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body cells, tissues and organs with oxygen and nutrients, and remove metabolic wastes.

Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot. A blood clot that causes damage to the heart muscles has been found to induce heart disease.

CVD is also found in many patients with high blood pressure which contributes to the hardening of the arteries.

Moreover, in the case of a blood clot that reduced blood flow to the brain, it causes a stroke.

Stroke is the leading cause of long-term disability in the United States. Each year, approximately 795,000 people suffer a stroke, including 600,000 first attacks, and 185,000 recurrent attacks.

According to the CVD statistics, heart disease kills more than 2,000 Americans every day.
Approximately 60 million Americans are living with heart disease.

Most common risk factors associated with the onset of cardiovascular disease are the increase of age. an unhealthy diet, lack of exercise, being overweight and smoking.

Lycopene is a phytochemical found in red fruits and vegetables in the class of carotenoid, a natural pigment with no vitamin A activity such as tomatoes, red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potent ingredient for the protection of cardio damage, researchers examined the lycopene's cardioprotective effects against DFS and tulathromycin.

The study included Swiss albino mice that were divided into seven groups (eight per group) received saline (control), tulathromycin (a single subcutaneous dose of 28 mg/kg/bw on day 14), DFS (a single oral dose of 100 mg/kg/bw on day 14), tulathromycin plus DFS, or lycopene (oral, 10 mg/kg/bw daily for 15 d) combined with tulathromycin, DFS, or both.

According to the tested analysis, tulathromycin or DFS treated groups (individually or in combination) displayed a significantly elevated (p < 0.05) serum levels of Creatine kinase-myocardial B fraction (CK-MB), lactate dehydrogenase, and cardiac-specific troponin-T, the cardio-markers associated with significant heart tissue damage.

Furthermore, cardio oxidative stress markers were also elevated in the tulathromycin or DFS treated groups tissue, including levels of nitric oxide and malondialdehyde.

The levels of antioxidant enzymes in the host treated by tulathromycin or DFS were significantly decreased observed in the cardio tissues, observed by the glutathione content and glutathione peroxidase, superoxide dismutase, and catalase antioxidant.

Moreover, compared to the control group, the mean pathology scores and the percentages of proteins involved in the production of pro-inflammatory cytokines were also increased substantially in the tulathromycin- and/or DFS-treated groups.

Believed it or not, co-administration of lycopene in the tulathromycin- and/or DFS-treated groups showed a significant amelioration of all parameter changes that caused cardio tissue damage.

Based on the findings, researchers said, "DFS could potentiate the cardiotoxic effects of tulathromycin, whereas lycopene can serve as a cardioprotective agent against DFS and tulathromycin."

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of cardio damage, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice by Abdel-Daim MM1, Eltaysh R2, Hassan A3, Mousa SA. (PubMed)