Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) casued by the immune system attacks the protective sheath (myelin) that covers nerve fibers.
MS causes communication problems between the brain and the rest of the body.
SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".
The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".
In other words, people having certain genes inherited from the parent are at the substantial risk of MS developing comapred to people who do not.
According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.
Conventionally, MS treatments are focusing on controlling inflammation that injures nerve fibers, reduces the frequency and severity of relapses, and preventing the accumulation of further nerve damage and improving symptoms and quality of life.
Most common symptoms of MS are numbness or weakness in one or more limbs, electric-shock sensations associated with certain neck movements, tremor, and lack of coordination physically.
In the vision, MS also induces symptoms of partial or complete loss of vision, prolonged double vision and blurry vision.
Additionally, patients with MS may also experience symptoms of slurred speech, fatigue, headache, dizziness, and reduced sexual, bowel and bladder function.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of multiple sclerosis (MS), researchers examined the efficacy of curcumin on a cascade of inflammation in the progression of different stages in MS patients.
Based on the tested analysis, curcumin inhibited the migration Th17cell into the central nervous system across the blood-brain barrier (BBB) in the induction of the tissue inflammation and tissue destruction by decoupling the production of pro-inflammatory cytokines (interleukin (IL)-17 and IL-22).
Where Th17 has been found to associated with hallmarks of many immune-inflammatory diseases.
In other words, curcumin blocked the axon degeneration and the various manifestations of nerve-muscle disorders associated with the onset of MS.
Furthermore, by searching the publication involved in curcumin treatment of MS, researchers found that the efficacy of curcumin for the treament of MS was attributed to numerous properties such as anti-inflammation and inhibition of secretion of proinflammatory cytokines.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of MS, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets by Ghanaatian N1, Lashgari NA1, Abdolghaffari AH2,3,4,5, Rajaee SM5, Panahi Y6, Barreto GE7,8, Butler AE9, Sahebkar A. (PubMed)
(2) Therapeutic potential of curcumin for multiple sclerosis by Qureshi M1, Al-Suhaimi EA2, Wahid F3, Shehzad O4, Shehzad A. (PubMed)
(3) Discovery of multiple sclerosis gene could inspire new therapies — if it’s right by SHARON BEGLEY. (Stat)
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