High Coffee Consumption Increased Risk of Neural Tube Defects for Women with Alternated Gene CYP1A2

Compared to herbal medicine, food therapy even takes longer to ease symptoms, depending on stages of the treatment which directly address the cause of disease.

Intake of the high amount of coffee and coffee caffeine during pregnancy may increase the risk of infant
Neural Tube Defects, a renowned institute study suggested

Neural tube defects are prenatal defects of infants related to the neuro system including the brain, spine, or spinal cord.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the study of total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002, returned questionnaire by participants showed a strong correlated between coffee and caffeine intake and risk of neural tube defect of spina bifida, But modestly increased risk of general NTDs and encephalocele.

More profoundly, in the reviewed literature in the database of PubMed, Springer Link and Elsevier databases up to August 2014, out of a total of six case-control studies and one cohort study,
The risk of neural tubal defects showed a relative odd ratio of 0.86 for total NTDs in pooled effect estimate of maternal coffee consumption during pregnancy, particularly in the spina bifida subtype of NTD.

According to the University of California women who carried alternated gene CYP1A2 (involved liver function in the metabolism of a foreign substance entering to the body) with a high amount of coffee and caffeine intake during pregnancy may also be associated to increased risk of neural tube defects (NTDs) due to increased oxidizer status.

In the self-reported coffee, tea, soda, and chocolate intake for mothers of 768 NTD cases, and 4143 controls delivered from 1997 to 2002. A subset of 306 NTD and 669 control infants and their parents with gene mutation, Mothers who consumed caffeine, bearing mutation genes in oxidization, CYP1A2*1F quickly and acetylated NAT2 slowly had a non significantly elevated the estimated risk for an NTD-affected pregnancy.

The risk of neural tube defects was multiplied many times in women who carry the lone mutated gene CYP1A2*1F.

Taking all together, pregnant women with a high amount of coffee and coffee caffeine consumption may have a nonsignificant risk to Neural Tube Defects and Subtypes. But for women with genetic alternative gene CYP1A2*1F should reduce intake of coffee with doctor recommendation during pregnancy.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Maternal caffeine consumption and risk of neural tube defects by Schmidt RJ1, Romitti PA, Burns TL, Browne ML, Druschel CM, Olney RS; National Birth Defects Prevention Study.(PubMed)
(2) Caffeine, selected metabolic gene variants, and risk for neural tube defects.
Schmidt RJ1, Romitti PA, Burns TL, Murray JC, Browne ML, Druschel CM, Olney RS; Nationa by Birth Defects Prevention Study(PubMed)