The Smoothie back by Clinical Trials and Studies of Respectable Institution of Olive, Broccoli and Mineral Water for Bipolar Disorder (Manic-Depressive)

Kyle J. Norton(Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Bipolar Disorder (Manic-Depressive)

Yield: 2 serving (about 8 ounce each)
1/4 cup olive
1/2 cups broccoli
3/4 cup grape
1 cup mineral water

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Bipolar Disorder (Manic-Depressive) with no adverse effects has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Bipolar disorder (manic-depressive) is a condition of mood swing not driven by the events of life, but as a result of abnormal gene or certain brain circuits could underlie bipolar of that can impair daily functioning and normal functioning at work by alternating periods of elation and depression. Some researchers suggested that the oxidative stress induced cell damage may also influence as a pathophysiology of bipolar mood disorder patients(1).

Recent studies back by clinical trials and studies from respectable institutions, suggested that omega-3 fatty acids(2) found in olive, alpha-lipoic acid found in broccoli(5) and mineral water(8) induced by cherry may be the next generation of therapeutic ingredient for reduced risk and treatment of Bipolar Disorder.

Olive is belongings to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is also called the olive and the source of olive oil. According to the The University of Melbourne, in review of the literature data base suggested that Omega-3 fatty acids may play an important role for treatment of Bipolar Disorder(2).

Dr. Lin PY and Dr. Su KP., researchers at the Chang Gung University College of Medicine said,"our meta-analysis showed significant antidepressant efficacy of omega-3 PUFAs, it is still premature to validate this finding due to publication bias and heterogeneity"(3), in a meta-analytic review of double-blind, placebo-controlled trials.
In backing to the use of Omega 3 fatty acids for treatment of Bipolar Disorder, Dr. and colleagues at the suggested, strong evidence in epidemiological studies exhibited the substantial relationship between omega-3 PUFAs and depression plausibly in diverse populations(4).

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. It has large flower heads, usually green in color surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe. In Oxidative stress induced Bipolar Disorder, Alpha-lipoic acid (ALA) found abundantly in broccoli, exhibited a possible antimanic effect, through inhibited oxidative stress and neurotrophic factors involved in the pathophysiology of bipolar disorder (BD)(5).
In neuropsychiatric disorders, Alpha-lipoic acid (ALA) displays a possible therapeutic neuroprotective effect against mitochondrial dysfunction when used conjunction with acetyl-L-carnitine (ALCAR), according to the Biological Psychiatry Laboratory, McLean Hospital(6).
In support of the effectiveness of (ALA) against Bipolar Disorder
Dr. Nierenberg AA and researchers at the Massachusetts General Hospital, Boston suggested in the treatment of bipolar patients with frequently relapse within 12 months of their previous mood episode, inhibition of mitochondrial dysfunction and potential MMs by alpha-lipoic acid (ALA), may be the best in reduced the pathophysiology of bipolar disorder(7).

Mineral water, a major source of lithium have found to be effective in preventing and treating Bipolar disorder(8).
Dr. Ketter TA, and colleagues at the Stanford University School of Medicine, in the comparison of the efficacy of quetiapine and lithium in acute mania, suggested the possibly greater efficacy for quetiapine compared with lithium in acute bipolar depression and in prevention of recurrent (particularly depressive) episodes(9).In a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania, early treatment with of lithium treatment may benefit the trajectory of cognition, such as verbal fluency in young people with bipolar disorder, according to the joint study lead by the Centre for Youth Mental Health, University of Melbourne(10).

The effectiveness of ingredients of olive, broccoli and mineral water should mimic the similar efficiency of their phytochemicals. It is hard to convince people that a enjoyable and delicious smoothie loved by everyone in the hot Summer day may consist the therapeutic values for reduced risk and treatment of some acute and chronic illness even they are back the clinical trials and studies by respectable institutions.

People who are at increased risk of Bipolar Disorder due to family history, gene mutation, psychological problem.. .....should drink at least one serving daily and people with Bipolar Disorder should drink the juices as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.


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References
(1) Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic andbipolar mood disorder patients by Ranjekar PK1, Hinge A, Hegde MV, Ghate M, Kale A, Sitasawad S, Wagh UV, Debsikdar VB, Mahadik SP.(PubMed)
(2) Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression by Sarris J1, Mischoulon D, Schweitzer I.(PubMed)
(3) A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids by Lin PY1, Su KP.(PubMed)
(4) Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique by Sontrop J1, Campbell MK.(PubMed)
(5) Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine by Macêdo DS1, Medeiros CD, Cordeiro RC, Sousa FC, Santos JV, Morais TA, Hyphantis TN, McIntyre RS, Quevedo J, Carvalho AF.(PubMed)
(6) A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression by Brennan BP1, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM.(PubMed)
(7) Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development by Nierenberg AA1, Kansky C, Brennan BP, Shelton RC, Perlis R, Iosifescu DV.(PubMed)
(8) Lithium for maintenance treatment of mood disorders by Burgess S1, Geddes J, Hawton K, Townsend E, Jamison K, Goodwin G.(PubMed)
(9) Treatment of bipolar disorder: Review of evidence regarding quetiapine and lithium.

Ketter TA1, Miller S2, Dell'Osso B3, Wang PW2.(PubMed)

(10) A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study by Daglas R1, Cotton SM2, Allott K2, Yücel M3, Macneil CA4, Hasty MK4, Murphy B5, Pantelis C6, Hallam KT7, Henry LP8, Conus P9, Ratheesh A10, Kader L4,Wong MT11, McGorry PD10, Berk M12.(PubMed)