The Smoothie of Orange and Green tea for Reduced Risk and Treatment of Cold Sores back by Clinical Trials and Studies

Kyle J. Norton(Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Cold Sores
Yield: 2 servings (about 8 ounces each)
1 1/2 cups orange
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Cold Sores with no adverse effects has encountered many obstacles, many ingredients showed initially promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Recent studies conducted by respectable institution suggested that green tea(1), Orange juice(3) may consist a potential response for reduced risk and treatment of cold sore with little or no adverse effects

Cold sores (Herpes labialis) is an infection of the lip as a result of the outbreak of by herpes simplex virus (HSV-1). The blister is healed within 2 - 3 weeks, but the virus remains dormant in the facial nerve and the rate of the recurrence of the diseases is very high to rare episodes to 12 or more.

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. According to the Zhejiang University,AverTeaX formulation containg high amount of catechins effectively inhibited herpes simplex labialis infection with clinical significance(1).

Dr Zhao M and colleagues in the study of inhibitory effects on herpessimplex virus suggested topical formulation containing EGCG-stearate in 100% glycerin USP effectively prevent and treat HSV-induced symptoms(2).

Orange is a species of Citrus Sinensis, belongings to the family Rutaceae, native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. Its juice contains highest amount of vitamin C in comparison of others. According to the Universidad Autonoma del Estado de Mexico, oral administration of 1 mg of lignin-ascorbic acid tablet or solution three times daily for a month inhibited HSV-1 infection(3).

In a randomized double-bind, placebo-controlled clinical trial, topical ascorbic acid-containing pharmaceutical formulation, Ascoxal, exerted anti antiviral effects herpes simplex virus with a statistically significant clinical result(4).

Dr. Terezhalmy GT, and colleagues in the study of treatment of recurrent herpes labialis suggested, application of different doses of water-soluble bioflavonoid-ascorbic acid inhibited the initial symptoms associated with recurrent herpes labialis(5).

The identified ingredients of catechins and vitamin C found abundantly in green tea and orange should provide us with strong evidences in support the use of smoothie in reduced risk and treatment of cold sore.

People who are at increased risk of Cold Sores due to family history, nutrient deficiency.. .....should drink at least one serving daily and people with Cold Sores should drink the juices as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.


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References
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) A proprietary topical preparation containing EGCG-stearate and glycerin with inhibitory effects on herpessimplex virus: case study by Zhao M1, Jiang J, Zheng R, Pearl H, Dickinson D, Fu B, Hsu S.(PubMed)
(3) A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus by Lopez BS1, Yamamoto M, Utsumi K, Aratsu C, Sakagami H.(PubMed)
(4) Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution by Hovi T1, Hirvimies A, Stenvik M, Vuola E, Pippuri R.(PubMed)
(5) The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis by Terezhalmy GT, Bottomley WK, Pelleu GB.(PubMed)