The Curable Smoothie of Green Tea, Tomato and Grape for reduced risk and treatment of Dementia

Kyle J. Norton(Scholar, Master of Nutrients) All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of dementia
Yield: 2 serving (about 8 ounce each)
1 1/4 cups blueberry
1/4 cup acocado
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of dementia has encountered many obstacles, many ingredients showed initially promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Recent studies by some well known institutions suggested that green tea(1), tomato(5) and green tea(8) may process phytochemicals and ingredients effectively in reduced risk and treatment of dementia.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. According to the Universidade Federal do Rio Grande do Sul, green tea (-)epigallocatechin-3-gallate inhibited dementia through reversed oxidative stress and reduced acetylcholinesterase activity(1) and ameliorated learning and memory deficits in diabetic rats(2).

Dr. Panza F and the colleagues at the joint study lead by the University of Bari Aldo Moro, insisted green tea consumption prevented or postponed the onset of AD and delayed or slowed the progression dementia(3).
Furthermore, green tea inhibited Aβ-induced paralysis through its aroma fraction and antioxidant effects, according to the Saitama Cancer Center , Saitama , Japan(4).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Recent study showed that patients with dementia are associated to low levels of plasma Carotenoids(5), the major chemical constituent found in tomato.
Lycopene, another major phytochemical found in tomato inhibited the early onset of dementia through its effect in modulation of nitric oxide against 3-NP-induced behavioral, biochemical and cellular alterations in rats(6). Dr. Kumar P and Dr. Kumar A.in study of the effects of lycopene and epigallocatechin-3-gallate gainst 3-Nitropropionic acid, a neurotoxin induced gait and memory impairment in test animals, suggested, lycopene and EGCG could be used to mange 3-NP induced behavioral and biochemical alterations through nitric oxide pathways(7).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape also inhibited symptoms of vascular dementia in postmenopausal elderly women, depending to chronic use manner(8). Dr. Hu J and colleagues at the Xiamen University, also found that resveratrol expressed its β-secretase inhibitor effect through inhibited β-secretase activity and β-amyloid generation in animal model(9).
Furthermore, the phytochemical also exerted its neuroprotective effects, through ameliorate the harmful effect against the expression of pro inflammatory cytokine pathways(10).

The identification of ingredient of Green Tea, Tomato and Grape may serve as a foundation for establish a potential and natural source for reduced early onset and treatment of dementia in sometime in the future.
People who are at increased risk of dementia due to family history and aging should drink at least 2 servings a day and people with dementia should drink as much as they can, depending to the digestive toleration. Change of life style and dietary pattern are recommended.

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References
(1) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(2) Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress by Baluchnejadmojarad T1, Roghani M.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)
(4) Green tea aroma fraction reduces β-amyloid peptide-induced toxicity in Caenorhabditis elegans transfected with human β-amyloid minigene by Takahashi A1, Watanabe T, Fujita T, Hasegawa T, Saito M, Suganuma M.(PubMed)
(5) Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort by Feart C1, Letenneur L2, Helmer C3, Samieri C2, Schalch W4, Etheve S4, Delcourt C2, Dartigues JF2, Barberger-Gateau P2.(PubMed)
(6) Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity by Kumar P1, Kalonia H, Kumar A.(PubMed)
(7) Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism by Kumar P1, Kumar A.(PubMed)
(8) Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion by Ozacmak VH, Sayan-Ozacmak H, Barut F.(PubMed)
(9) The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation by Hu J1, Lin T2, Gao Y3, Xu J2, Jiang C2, Wang G2, Bu G3, Xu H1, Chen H2, Zhang YW3.(PubMed)
(10) Effects of resveratrol on apoptosis in a rat model of vascular dementia by Sun ZK1, Ma XR2, Jia YJ2, Liu YR2, Zhang JW1, Zhang BA2.(PubMed)