All About Vitamins: Niacin in Reduced Complications and Treatment of Gestational Diabetes

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin and its derivative may have a profound effect in reduced risk of complications caused by gestational diabetes mellitus, a university study suggested.

Gestational diabetes mellitus, is a type of  glucose intolerance occurred only in the first recognition of pregnancy. The condition will resolve itself after giving birth.

Unfortunately, women with gestational diabetes is susceptible to increased risk of  early onset of diabetes.

According to the study conducted by the Universiti Teknologi MARA (UiTM), oral administration of nicotinamide supplementation exhibited anti gestational diabetes mellitus, effect in lower elevated glucose and reduced insulin through all aspects of diabetic parameters.

In animal study, nicotinamide in doses of 50, 100 and 200 mg/kg applied to gestational diabetic fed to rats from days 6 through 20 of gestation showed a significant in reduced diabetes symptoms through increased production of antioxidants, reduced inflammatory cytokins and genes in controlling expression of free radicals.

The doses of 100 and 200 mg/kg t showed an extensive effect against the oxidative burst activity of neutrophils in response to cell differentiation of phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) in elevated risk of diabestes complications as well as activating T helper (CD4+CD25+) cells and inducing proliferation of splenocytes, a type of white blood cell involved autoimmune diabetes mellitus expression.

The findings propsoed that nicotinamide as supplement may be used as therapeutic agent in support  existing treatment for gestational diabetes and pregnant individuals with weakened immune systems.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells by Guoqiang Jiang‡, Qing Dallas-Yang, Franklin Liu, David E. Moller and Bei B. Zhang by (Journal Biological Chemistry)
(2) Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses by John CM1, Ramasamy R, Al Naqeeb G, Al-Nuaimi AH, Adam A.(PubMed)

All About Vitamins: Niacin Overdoses and The Risk of Toxicity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may induce liver toxicity if over dose, a joint study lead by the Mayo Clinic insisted.

In a analysis of a A 17-year-old male was transferred to the pediatric intensive care unit for evaluation of acute liver failure, researchers found that elevated liver transaminases induced acute liver toxicity caused by over dose of niacin intake to alter the outcome of an upcoming drug test.

Due to the severity of the case, Dr. Ellsworth MA, the lead author said, "Pediatric providers should be aware of the risks associated with niacin toxicity and other experimental medical therapies that may be described on the Internet or other nonreputable ".

Other in the differentiation of a 23-year-old healthy man presented to an Emergency Department with altered mental status, fever, acute renal failure, microangiopathic hemolytic anemia, thrombocytopenia, and coagulopathy,doctors at the Carolinas Medical Center, found that respiratory failure and hemodialysis for acute renal failure were caused by intake of 22.5 g of sustained-release niacin over the preceding 48 h with an attempt to pass a pre-employment urine drug screen.

Dr, Daul AM, the lead researcher warmed, " Although this patient was fortunate to make a full recovery, the case highlights the potential for multi-system toxicity with niacin overdose, and the potential for harm posed by medical misinformation on the Internet".

Taking altogether, overdoses of niacin may cause significant damage to your health in exhibited long term liver and kidney damage if not treated immediately.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Acute liver failure secondary to niacin toxicity by Ellsworth MA1, Anderson KR2, Hall DJ2, Freese DK3, Lloyd RM4.(PubMed)
(2) Niacin toxicity resulting from urine drug test evasion by Daul AM1, Beuhler MC.(PubMed)

All About Vitamins: Niacin as Antioxidant

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Antioxidant is a chemical compound with function in inhibited oxidation caused by imbalance of oxygen molecules.

Niacin may have a profound effect in reduced risk of free radical expression by exhibiting antioxidant activity, a renowned study suggested.

In the study of animals, randomly assigned to one of 4 groups (n = 6): Group I, control, received distilled water by gavage; Group II, received MeHg (100 µg/kg/d) by gavage; Group III, received NA (50 mg/kg/d) in drinking water; Group IV, received MeHg (100 µg/kg/d) by gavage + NA (50 mg/kg/d) in drinking water, niacin fed mice exerted a significant effect in reduced adverse effects of toxicity produced by MeHg, through its the intrinsic antioxidant property.

The interaction of niacin also ameliorated oxidative stress through improved the presence of antioxidants of glutathione peroxidase (GPx) and catalase (CAT) and reduced levels of free radicals of glutathione (GSH), malondialdehyde (MDA), and nitric oxide.

Promisingly, in the study of 21 patients older than 18 years, with HDL-C ≤40 mg dl-1 (men) or ≤50 mg dl-1 (women), randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over, niacin treatment showed positive outcomes in activated paraoxonase-1 (PON1) function in anti-atherosclerotic component of high-density lipoprotein (HDL). and promoted the anti-oxidant and anti-inflammatory functions of HDL.

Although, niacin expressed the impressive effect in improved antioxidant status in treated patients, the amounts do not match up to rise in HDL-C achieved in induced aApoA-I antibodies activity, Dr. Batuca JR, the lead author said, " (due to these result) niacin and other lipid lowering agents fail to reduce cardiovascular risk".

Taking together, there is not doubt that niacin or its derivative Extended-release niacin (ERN) may have a potential effect in reduced risk of lipid peroxidation through increasing high-density lipoprotein-cholesterol (HDL-C) and be considered as therapeutic treatment of abnormal cholesterol expression.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective effects of niacin against methylmercury-induced genotoxicity and alterations in antioxidant status in rats by Silva de Paula E1, Carneiro MF1, Grotto D2, Hernandes LC3, Antunes LM3, Barbosa F Jr1.(PubMed)
(2) Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidanteffect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial by Batuca JR1, Amaral MC1,2, Favas C2, Paula FS1,2, Ames PRJ1, Papoila AL3, Delgado Alves J1,2.(PubMed)

All About Vitamins: Niacin, A Potent Anti Acne Vitamin

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin and its derivatives may have a potential effect used over counter medicine for treatment of acne, a joint study led by the University of Miami Miller School of Medicine. suggested.

In the review of database from PubMed for clinical studies, using nicotinamide for treatment of acne vulgaris, including 10 studies met search criteria, in compared to baseline or other standard-of-care acne treatment, 6 out of 8 studies expressed the positive effect of topical nicotinamide in reduction in acne.

Oral supplement containing nicotinamide from other studies showed a significantly improved  reduction in acne in compared with baseline.

Either topical and oral administration showed no major adverse side effects, the study also found.

Other in a randomized, double-blind clinical trial, patients with moderate inflammatory facial acne vulgaris randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily, group treated with topical 4% nicotinamide showed an  acne grade decreased from an average of 5.93 at baseline to 4.03 at week 4 and 2.08 at week 8 in compared to
5.70 at baseline to 3.85 at week 4 and 2.03 at week 8 in the clindamycin group.

Further consultation insisted that skin types of patients may play an important role in choosing products as nicotinamide and clindamycin gels were significantly more efficacious in oily and non-oily skin types, respectively.

Both products showed insignificantly adverse side effects during the course of study.

Due to the limited nature of the available literature, some researchers suggested that additional studies are needed in comparing nicotinamide to other first-line acne treatments over an extended period of time may be necessary.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The role of nicotinamide in acne treatment by Walocko FM1, Eber AE2, Keri JE2,3, Al-Harbi MA4, Nouri K2.(PubMed)
(2) Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris by Khodaeiani E1, Fouladi RF, Amirnia M, Saeidi M, Karimi ER.(PubMed)

All About Vitamins: Niacin Overload in increased Risk of Obesity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Chronic niacin excessive intake may be associated to risk of obesity a study by the Medical College, Dalian University suggested.

Obesity is a medical condition of excess body fat has accumulated overtime with a BMI of over 30.

 According to the statistic, 68% of American population are either overweight or obese.

According to the examine between the niacin consumption and the obesity prevalence among US children using the data from the Economic Research Service of the US Department of Agriculture and from US Centers for Disease Control and Prevention, respectively, increased consumption of grain niacin-fortification and fortified ready-to-eat cereal consumption, with a 10-year lag increased per capita niacin consumption among Us children may be one of the risk factor in elevated obese risk.

Dr. Li D, the lead author said, " The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption (R(2) = 0.814, 0.961 and 0.94 for 2-5 years, 6-11 years and 12-19 years age groups, respectively)".

In deed, the appetite-stimulating effect of nicotinamide involved oxidative stress may be directly induced excess niacin consumption and considered as a major factor in the increased obesity prevalence in US children.

Additionally, in the study to determine whether and how long-term treatment with nicotinamide) NAM at lower dose would affect insulin sensitivity in mice fed chow diet with NAM (100 mg/kg/day) and normal chow for 8 weeks, researchers found that NAM (100 mg/kg/day) injection group induced obesity and expressed a significant in increased glucose intolerance and skeletal muscle lipid accumulation through impaired mitochondrial respiration capacity and energy production in skeletal muscle.

The excessive niacin overload also showed a persistent rate of oxidative stress in compared to high-fat diet (HFD) and resveratrol (RSV; 100 mg/kg/day) group.

Taking together, there is no doubt that niacin overload may have a direct influence to increased risk of obesity through expression of oxidative stress induced increased glucose intolerance and skeletal muscle lipid accumulation

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(1) Chronic niacin overload may be involved in the increased prevalence of obesity in US children by Li D1, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M.(PubMed)
(2) Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity by Qi Z1, Xia J2, Xue X2, He Q2, Ji L2, Ding S3.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin Lowers Hypercholesterol and risk of CVD in Diabetic patients

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may have a potential in reduced risk of hypercholesterol and cardiovascular disease in patients with diabetes, a Medical institute suggested.

According to the School of Medicine and Pharmacology, niacin exhibited HDL metabolism in reduced all forms of bad cholesterol and increased good cholesterol level in patients with type 2 diabetes.

In a total of 12 men with type 2 diabetes mellitus recruited for a randomized, crossover design trial, patients randomized to rosuvastatin or rosuvastatin plus ER niacin for 12 weeks and then crossed over to the alternate therapy after a 3-week washout period, metabolic assay showed that extended-release (ER) niacin treatment significantly decreased plasma triglyceride, plasma cholesterol, non-HDL cholesterol, low-density lipoprotein cholesterol, articular in HDL cholesterol in compared to other groups.

Dr. the lead researcher said, " ER niacin increases HDL apoA-I concentration in statin-treated subjects with type 2 diabetes mellitus by lowering apoA-I(in measurement of cardiovascular risk) fractional catabolic rate".

In the same same group of patients with type 2 diabestes, in compared the effective of rosuvastatin or rosuvastatin plus ER niacin, extended-release (ER) niacin on apolipoprotein B-48 (apoB-48) kinetics in statin-treated treatment also showed a reduction of level of apoB-48 concentration, but significant lower than group treated with conventional treatment.

The study also emphasized that the ER niacin exhibition of reduced cardiovascular risk showed independent to the levels of triglyceride, according to testing assay.

In fact, the efficacy of ER in reduced risk of CVD may be resulted of reduction of apoB-48 concentration through lowering fasting and postprandial apoB-48 secretion rate.

Taking together, niacin injection may have a profound effect in treating diabetic patients in ameliorated risk of CVD through expression of lower level of total blood cholesterol.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of niacin on high-density lipoprotein apolipoprotein A-I kinetics in statin-treated patients with type 2 diabetes mellitus by Pang J1, Chan DC, Hamilton SJ, Tenneti VS, Watts GF, Barrett PH.(PubMed)
(2) Effect of niacin on triglyceride-rich lipoprotein apolipoprotein B-48 kinetics in statin-treated patients with type 2 diabetes by Pang J1, Chan DC1, Hamilton SJ1,2, Tenneti VS1, Watts GF1, Barrett PH1,3.(PubMed)

All About Vitamins: Niacin in reduced Risk of High Levels of Phosphorus in Kidney Diseases

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered a dietary supplement in reduced risk and progression of kidney diseases, a renowned institute study suggested.

Kidney diseases are medical condition characterized by impairment of kidney function in filter metabolic wastes from the blood.

According to the University of Karachi, niancin treatment over 4 months, showed a significant effect in reduced risk dyslipidemia and phosphorus level, in compared to control group treated with statin.

in a study of chronic kidney disease patients fulfilling the pre-defined criteria and randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or NER 500 mg/day with the same dose of statin.

In compared to conventional medicine atorvastatin, niacin extended release (NER) scored a significant result in decreased levels of phosphorus than atorvastatin, used as lone treatment.

Dr. Yasmeen G, the lead researcher said," its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction.".

Instantly, in the post hoc data analysis of serum phosphorus concentrations among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268). only one of daily treatment of ERN-L  expressed a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline in compared to other groups.

Further more, the testing of extended release niacin (ERN) alone and ERN combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (ERN-L), treatment of extended release niacin (ERN) also showed a same effect in reduced serum FGF23 concentration in compared to 2 other groups, with equivalent declines in serum phosphorus in (ERN-L) group but not in placebo group.

Taking altogether, there is no doubt that niacin under the form extended release niacin (ERN) may have a potential used conjunction of with conventional medicine in reduced complications of kidney diseases caused high levels of phosphorus.

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Sources
(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)
(3) Effect of niacin on FGF23 concentration in chronic kidney disease by Rao M1, Steffes M, Bostom A, Ix JH.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin in reduced Risk Oxidative Stress

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered as dietary supplement in reduced risk of oxidative stress in induction of various diseases, a respectable institute study opinionated.

In a total of 127 men and women aged 48-77 yr with brachial artery flow-mediated dilation (FMD), patients, above-average dietary niacin intake showed a significant greater function in compared to those below-average intake (P < 0.05).

The study also found that above-average dietary niacin intake patients showed a lower levels of oxidative stress through expression of plasma oxidized low-density lipoprotein.

Further more, levels of antioxidants also has linearly association to amount intake of niacin as shown in this participants.

Dr. Kaplon RE, the lead author said, " higher dietary niacin intake is associated with greater vascular endothelial function related to lower systemic and vascular oxidative stress among healthy middle-aged and older adults."

In support of the above analysis, the study of 17 patients with hypercholesterolemia and low HDL-C and 8 healthy control subjects, 12 weeks.of niacin treatment showed a strong improvement of lipid profile, oxidative stress and C-reactive protein (CRP) levels, through increase in HDL-C and apolipoprotein A1 levels involving transferred to HDL in the bloodstream and a decrease in triglyceride levels.

More promisingly, Niacin treatment in these patients with low HDL levels showed a significant in reduced oxidative stress through improved activities in regulated C-reactive protein (CRP) levels and lipid profiles.

Taking altogether, There is no doubt that niacin may be considered as a dietary treatment in reduced risk of diseases caused by oxidative stress.

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Sources
(1) Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults by Kaplon RE1, Gano LB, Seals DR.(PubMed)

(2) Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol by Hamoud S1, Kaplan M, Meilin E, Hassan A, Torgovicky R, Cohen R, Hayek T.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All about Vitamins: Niacin, A dietary Supplement for Enhanced Immunity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be a potential agent in promoted immune response against invasion of micro bacterial invasion. a renowned institute suggested.

Immune responses is a normal reaction of immune system in prevented infection and inflammation caused by foreign invasion, and further injure and damage due to wound of body tissues and organs.

According to the study of 30% of HIV-1-infected patients receiving antiretroviral therapy in reduced elevated risk for clinical progression to AIDS and non-AIDS events, involving CD4+ T-cell depletion, extended-release form of niacin (Niaspan FCT™) in combination with antiretroviral therapy, showed a significant effect in improved immune activation, thus increasing CD4 recovery in compared to deferred use of Niaspan patients after 24 week periods.

Apparently, niacin expressed a strong expression pf suboptimal immune responses, through its impact of on neurocognitive function in HIV-infected individuals.

Dr. Lebouché B, the lead author said, " Niacin (vitamin B3) is able to control the excess tryptophan oxidation, correcting tryptophan depletion, and therefore represents an interesting strategy to improve CD4 recovery".

Niacin, in other study, with direct action in regulation of inflammatory responses or disordered immune mechanisms may be considered as a supplementary therapy in rheumatic diseases, atopic disorders and chronic infections. 

In order to achieve a optimal effect of niacin as immunostimulating therapy, other micro and marco nutrients such as suboptimal levels of EFAs, vitamins and trace elements should always be taken into account, the study also suggested.

More importantly, NAD in synthesis of mono ADP-ribose, expressed a significant involvement in signal transduction. as the vitamin showed to important function in mediation of two intracellular calcium signaling pathways to enhance immunity against cancer cell division through improved genomic stability.

Dr. Kirkland JB, said, " niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations".

Taking together, niacin as a dietary supplement may have a potential effect in reduced risk of any form disease involving action of  immune system.

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Sources
(1) The role of extended-release niacin on immune activation and neurocognition in HIV-infected patients treated with antiretroviral therapy - CTN PT006: study protocol for a randomized controlled trial by Lebouché B1, Jenabian MA, Singer J, Graziani GM, Engler K, Trottier B, Thomas R, Brouillette MJ, Routy JP.(PubMed)
(2) Specific application of single nutrients as a basic treatment in immunostimulating therapy by Reinhold U.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin Reduced Risk and Treatment Glaucoma?

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin supplement may have a potential effect in reduced risk and treatment glaucoma, a Pennsylvania study suggested.

Intake of 500 mg of oral niacin(also known as vitamin B3 or nicotinic acid) daily is shown to increased intraocular pressure to 37 and 27 mm Hg, according to the the Jefferson Medical College. study.

In the exam of 73-year-old man with a history of primary open-angle glaucoma, intake of niacin have a significant effect on the eye pressure which may be increased or decreased depending to amount of niacin intake.

The increased abnormal eye pressure also reduced to normal once niacin intake was stopped.

The finding is contrasted to the investigation of mice treated with nicotinamide adenine dinucleotide (NAD), in genetically predisposed to developing glaucoma with healthy mice acted as control, in indication of niacin effect in treatment of glaucoma through anti oxidative stress by Dr. John and colleagues. 

According to Dr. John and colleagues study, the depletion of NAD weakens the metabolism of the brain cells, and intraocular pressure may have a direct influence on the onset of glaucoma. And  in glaucoma-predisposed mice, adding niacin to the drinking water showed to improve aging retinal ganglion cells and modify the neuro change associated with advancing age and prevent the early onset of glaucoma.

Taking altogether, intake of niacin supplement to reduced risk and treatment of glaucoma may need further studies by larger human trial and involvement of multi centers before confirming.

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Sources
(1) Oral niacin can increase intraocular pressure by Tittler EH1, de Barros DS, Navarro JB, Freitas DG, Gheith ME, Siam GA, Spaeth GL.(PubMed)
(2) http://dailyhealthalerts.com/new-study-vitamin-b3-may-help-glaucoma-and-macular-degeneration/
(3) Vitamin B-3 successfully prevents glaucoma in mice by By Ana Sandoiu
Published Friday 17 February 2017(Medical News Today)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin reduced risk of co-morbidities in patient with chronic kidney disease.

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Kidney disease is a medical condition of kidney impairment, characterized by adequately filter metabolic wastes from the blood.

Niacin may have a potential effect as phosphorus lowering agents in patient with ischemic nephropathy, inducingvarious types of syndromes and diseases,  a joint study suggested.

According to the University of Karachi, Karachi, niacin may be one of low cost supplement used management effectively in attenuated elevated serum phosphorus in patient population with compromised kidney performance. Thus reducing co-morbidities especially cardiovascular disease risk and derangement in calcium-phosphorus homeostasis in advancing to onset of chronic kidney disease.

In the study of 170 chronic kidney disease patients and 50 healthy control, fulfilling the pre-defined criteria, randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or extended release niacin(NER) 500 mg/day with the same dose of statin for four months, injection of atorvastatin alone and NER showed a significantly reduced phosphorus level.

In compared to the adverse effect in both treatments, the university also said, "NER, at its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction".

Furthermore, in data analysis of serum phosphorus concentrations, among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268), repeated measurement of ERN-L treatment resulted in lowering serum phosphorus change comparing ERN-L with placebo.

Dr. Maccubbin D, the lead author siaid, "once-daily ERN-L treatment causes a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline".

Taking together, niacin may be effective for enhanced kidney function by reduced level of phosphorus in both healthy and chronic kidney disease patients. intake of large amount should be taken with care under close observation by medical professional.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)

All About Vitamins: niacin in Prevented Migraine Caused by Low Level of Serotonin

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be one of the B vitamin with a substantial effect in migraine prevention, a renowned institute study suggested.

According to the Division of Pain Management Mayo Clinic, niacin showed to increase plasma serotonin levels in reduced migraine expression at the early stage.

Sustained-release niacin merits may be important to provide a potentially useful preventive therapy for migraine headache. Dr. Velling DA, the lead authors insisted.

Furthermore, in the review of literature in English and non-English language articles of the databases: MEDLINE (1966-February 2004), AMED (1995-February 2004) and Alt HealthWatch (1990-February 2004),  9 articles met the inclusion criteria included in this systematic analysis showed a moderated effect of niacin in prevented migraines and tension-type headaches not only through its vasodilatory properties but also improved mitochondrial energy metabolism.

Unfortunately, although adverse effects are well tolerated, some patients experience serve flushing, nausea and fainting.

Dr. Prousky J, the lead researcher said. "Although niacin's mechanisms of action have not been substantiated from controlled clinical trials, this agent may have beneficial effects upon migraine and tension-type headaches. Adequately designed randomized trials are required to determine its clinical implications".

Taking together, as a supplement, niacin may be effective in prevented migraine caused by low level of serotonin..

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Sources
(1) Sustained-release niacin for prevention of migraine headache by Velling DA1, Dodick DW, Muir JJ.(PubMed)
(2) The treatment of migraines and tension-type headaches with intravenous and oral niacin(nicotinic acid): systematic review of the literature by Prousky J1, Seely D.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin on Obesity and Obese Toxicity

By Kyle J. Norton.

Chronic niacin and vitamins overload may induce risk of obesity and obese toxicity, a renowned institute study suggested.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Dalian University, co-administration of glucose and 300 mg nicotinamide in animal study showed a significant elevated levels of RSO and insulin levels but the 3-h blood glucose test showed the levels of was significantly lower.

The study result indicated that niacin not only has an appetite-stimulating effect involved oxidative stress but also be concerned as a major factor in the increased obesity prevalence in US children with excess consumption.

Dr.Li D, the lead author said, "The obesity prevalence among American children increased with the increasing per capita niacin consumption, the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat cereal consumption, with a 10-year lag".

Furthermore, in other same subject study conducted by the same university, intake of excess amount of vitamin supplement and fortify food have found to accompany by an increased prevalence of obesity, a condition associated with diabetes, hypertension, cardiovascular disease, asthma and cancer.

Recent experiment also suggested that not only excess niacin showed to induced obesity, obese patients also exhibited low fasting serum but high erythrocyte folate concentrations, exhibiting folate oxidation involved oxidative stress. 

Dr. Zhou SS, the lead author said, "here is also evidence that obesityincreases niacin degradation, manifested by increased activity/expression of niacin-degrading enzymes and high levels of niacin metabolites" and " that low fasting serum vitamin status in obesity may be a compensatory response to chronic excess vitamin intake, rather than vitamin deficiency, and that obesity could be one of the manifestations of chronic vitamin poisoning".

The finding evidenced proposed that excess vitamins intake may have a potential toxic effect in obese patients.

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Sources
(1) Chronic niacin overload may be involved in the increased prevalence of obesity in US children by Li D1, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin, A supplement for Improved immune responses

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Immune responses is a natural reaction of immune system against foreign invasion such as bacteria, viruses, and substances.

Niacin may have a profound effect in exhibited immune response against various type of invasive and inflammatory diseases, a Brazilian study opinionated.

According to the Institute of Biological Sciences, UFMG, in BALB/c mice, injection of nicotinic acid showed a significant activities in reduced production of inflammatory cytolions and stimulated the performance of chemoattractant in response to carrageenan against over expression of neutrophil.

Dr. Ferreira RG, the lead author said, "nicotinic acid plays an important role in the regulation of inflammation due to its ability to inhibit the actions of the neutrophil chemoattractants IL-8 and LTB4(inflammatory mediators)".

Truly, the study also insisted that niacin treatment in exhibited the chemoattractants may attenuate the impairment of white blood cells rolling and adherence to vascular endothelium in the microcirculation of inflamed tissues.

Other, in support of the above evaluation of neutrophil recruitment in IL-8-, LTB(4)- or carrageenan-induced pleurisy in mice, niacin treatment niacin improved immune response through reduced expression of inflammatory cytokins in inflammatory reaction of immune functioning.

The study also suggested that the efficacy of niacin in induced immune responses against action of proteins in regulated  pro and con inflammation.

The findings indicated that niacin may have a direct effect in improve immune response again foreign invasion in inducing infections and inflammation through expression in leukocyte migration from blood vessels into tissues.

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Sources
(1) Niacin inhibits carrageenan-induced neutrophil migration in mice by Ferreira RG1, Matsui TC, Gomides LF, Godin AM, Menezes GB, de Matos Coelho M, Klein A.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Niacin in Reduced risk Skin Cancer

By Kyle J. Norton.


Nicotinamide, an amide form of vitamin B3, may have a potential effect in reduced risk of skin cancer of type squamous cell carcinoma (SCC), the recent respectable university suggested.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Skin cancer is a condition characterized by abnormal cell group in skin of the body.

In the review of 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010), with niacin intake assessed every 2 to 4 years during follow-up and cumulative averaged intake,  niacin injection was inversely associated with risk of skin cancer in total documented 23,256 BCC, 2,530 SCC and 887 melanoma cases.

The investigation also addressed the gender different in higher total niacin intake and risk of melanoma.  As men is found to marginally positively associated with melanoma risk, but not in women.

Also, according to the study, niacin may be effective in reduced risk and treatment of skin cancer of type squamous cell carcinoma (SCC) but not of BCC or melanoma.

Other researchers in the human trials of phase 3, double-blind, randomized, controlled trial, randomly assigned, in a 1:1 ratio of 386 participants who had had at least two nonmelanoma skin cancers in the previous 5 years to receive 500 mg of nicotinamide twice daily or placebo for 12 months witj participants evaluated by dermatologists at 3-month intervals for 18 months, suggested that treated patient showed a significant lowering nonmelanoma skin cancers by 23% at 12 months with compared placebo.

Both groups expressed  the similar differences with respect to new cases of basal-cell carcinomas and new squamous-cell carcinomas.

Also in compared to placebo, nicotinamide group showed a lower of number of actinic keratoses incidence, a scaly growth caused by damage from exposure to ultraviolet (UV) radiation  by 11% at 3 months (P=0.01), 14% lower at 6 months (P<0.001), 20% lower at 9 months (P<0.001), and 13% lower at 12 months (P=0.001).

Taking together, Niacin and it's dietaryNicotinamide may be a potential and therapeutic vitamin supplements for reduced risk and treatment for certain types of skin cancer.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Nicotinamide and the skin by Chen AC1, Damian DL.(PubMed)
(2) Niacin intake and risk of skin cancer in US women and men by Park SM1,2,3, Li T1, Wu S4,5, Li WQ4,6, Weinstock M4,6,7,8, Qureshi AA1,4,6,8, Cho E1,4,6.(PubMed)
(3) A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention by Chen AC1, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL.(PubMed)

All About Vitamins: Niacin and Schizophrenia

By Kyle J. Norton.

Niacin sensitivity and response may be associated to the developed schizophrenia, a renowned institute study suggested.
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Schizophrenia is a mental condition characterized by failure between thought, emotion, and behavior affecting patient ability in differentiated perception, appropriate actions and feelings......

 Schizophrenia patients showed a diminished neither sensitivity nor efficacy of niacin correlated with AA levels, in constrast to a significant correlation between AA levels and niacin sensitivity in control group according to the study of injection of eight concentrations of methylnicotinate to the forearms of 20 adults with schizophrenia and 20 controls,

The study also addressed that the levels of adrenic acid showed a strong correlated with niacin efficacy in schizophrenia patients and the correlation between adrenic acid and niacin efficacy in schizophrenia indicated other mechanism, such as expression of n-6 PUFA may involve to the blunted niacin response.

Dr. Messamore E, the lea author said, "The schizophrenia-associated niacin response abnormality involves both diminished sensitivity and reduced efficacy. The lack of expected correlation between levels of AA and adrenic acid suggests homeostatic imbalance within the n-6 polyunsaturated fatty acid (PUFA) pathway in schizophrenia".

Additionally, in the study of normal skin flush response, niacin attenuated in many individuals with schizophrenia (SCZ), showed an abnormal response to niacin, in inducing abnormal prostaglandin signaling due to depletion of AA, and other essential fatty acids (EFAs).

Other researchers insisted that the abnormal of niacin response of schizophrenia may also be associated to larger machenisms, including abnormalities in enzymes, receptors, or signal transduction mechanisms that affect the synthesis, release, or response to vasodilatory prostaglandins.

Taking together, there is no doubt that patient with schizophrenia is associated to niacin abnormal response and sensitive involved expression of many effects.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Niacin sensitivity and the arachidonic acid pathway in schizophrenia by Messamore E1, Hoffman WF, Yao JK.(PubMed)
(2) The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study by Messamore E1, Hoffman WF, Janowsky A.(PubMed)

All About Vitamins: Vitamin B3 deficiency induced Dementia in Pellagra Patients

By Kyle J. Norton.

Vitamin B3 deficiency may be associated to the early onset and progressive risk of dementia in patients with pellagra, a respectable institute proposed.

 Dementia, the neurodegenerative diseases characterized by the loss of mental ability severe enough to interfere with people's every life. Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Pellagra is a nutritional deficiency of tryptophan and niacin (nicotinic acid) disease

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Kyoto University Graduate School of Medicine, dementia induced by patients with Pellagra, a photosensitivity syndrome postulated an exhibition of reactive oxygen species(ROS) production through increased levels of hormone prostaglandin E₂.

In niacin deficient mice model of pellagra, mice showed a significantly elevated inflammatory expression levels of COX-2, and PGE syntheses, in induced risk dementia.

In a case reported by the Anning Hospital, male with a classic case of pellagra bought to the hospital was found to process disorderly behavior induced cardinal symptoms of dermatitis, dementia caused by niacin deficiency.

The patients made a complete recovery after 6 months of appropriated treatment including supplement of niacin.

Additionally, in a case-control study of compared the past dietary habits of 342 Parkinson's disease (PD) patients recruited from nine German clinics with those of 342 controls from the same neighborhood or region, niacin intake through supplement or high niacincontent in coffee and alcoholic beverages, are found to have a inversely associated with PD.

The findings suggested that niacin plays a important role in reduced risks of pellagra expression of dementia and Pakistan disease.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production by Sugita K1, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K.(PubMed)
(2) Case report of mental disorder induced by niacin deficiency by Wang W1, Liang B1.(PubMed)
(3) Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study by Hellenbrand W1, Boeing H, Robra BP, Seidler A, Vieregge P, Nischan P, Joerg J, Oertel WH, Schneider E, Ulm G.(PubMed)

All About Vitamins: Niacin and Risk of Depression

By Kyle J. Norton.

A 2015 study by a renowned institute suggested that niacin and other nutrient deficiency may be associated to a risk factor of psychological syndrome of depression.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. The vitamin is associated to cellular integrity and energy production involved in more than 500 intracellular reactions.

In a total of 130 older subjects participated in the study with 65 diagnosed depression (16 men and 49 women) and 65 age- and sex-matched controls without depression, the incidence of depression may be attributed the poor nutrients intake, including more intake of of sucrose and insufficient consumption of protein, fiber, eicosapentaenoic acid, niacin and vitamin B6.

The study also indicated that these nutrient inappropriate in patients with depression also expressed a lower quality of life in compared to control, by comprehensive geriatric assessment.

Other, in cross-sectional study conducted of the intake of major (that is, carbohydrates, fat, and protein) and minor (that is, vitamins and minerals) nutrients in adults with confirmed mood disorders, higher intake of nutrients are significant correlations to higher mental function and inversely associated to risk of mental disorder.

Mood disordered patients also showed a mild and moderated expression of depression, but not consistently.

Taking together, there is no doubt that deficiency of niacin other nutrients may exaggerated  the risk of depression.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression by Guligowska A1, Pigłowska M1, Fife E1, Kostka J2, Sołtysik BK1, Kroc Ł1, Kostka T1.(PubMed)
(2) Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders by Davison KM1, Kaplan BJ.(PubMed)

All About Vitamins: Niacin in Prevention of Complication of Pellagra in Anorexia Nervosa

By Kyle J. Norton.


Niacin may be used as therapeutic form of treatment in patients of Anorexia Nervosa with complication of pellagra, a renowned institute insisted.

Anorexia nervosa is a type of eating disorder usually develop in the teen years and effect over 90% of female, because of excessive food restriction and irrational fear to become fat due the wrongly influenced media as attractiveness is equated to thinness.
Pellagra is a nutritional deficiency disease of tryptophan and niacin (nicotinic acid)

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

According to the Canadian College of Naturopathic Medicine, the reviewed literature revealed several cases of pellagra in patients with anorexia nervosa whose cutaneous symptoms resolve, such as erythema on sun-exposed areas, glossitis, and stomatitis. were resolved within 24-48 hours after oral niacin administration of 150-500 mg.

Furthermore, there are other cases of a 14-year-old girl and 20-year-old woman with disorders of anorexia nervosa symptoms of pellagra were treated successfully with niacin therapy and dietary treatment.

Dr. Jagielska G, the lead author in the study conducted by the Medical University of Warszaw, said, " Pellagra is a potentially fatal, nutritional disease with cutaneous, gastrointestinal, and neuropsychiatric manifestations. Because of the diversity of pellagra's signs and symptoms, diagnosis is difficult without an appropriate index of suspicion".

The finding evidences suggested restriction diets in patients diagnosed with anorexia nervosa may cause significant nutritional deficiency, inducing Pellagra, although it is not common.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pellagra may be a rare secondary complication of anorexia nervosa: a systematic review of the literature by Prousky JE1.(PubMed)
(2) Pellagra: a rare complication of anorexia nervosa by Jagielska G1, Tomaszewicz-Libudzic EC, Brzozowska A.(PubMed)
(3) Pellagra in a patient with anorexia nervosa by Rapaport MJ.(PubMed)
(4) Nutritional deficiencies and the skin by MacDonald A1, Forsyth A.(PubMed)

All About Vitamins: Niacin and Depression

By Kyle J. Norton.

A 2015 study by a renowned institute suggested that niacin and other nutrient deficiency may be associated to a risk factor of psychological syndrome of depression.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. The vitamin is associated to cellular integrity and energy production involved in more than 500 intracellular reactions.

In a total of 130 older subjects participated in the study with 65 diagnosed depression (16 men and 49 women) and 65 age- and sex-matched controls without depression, the incidence of depression may be attributed the poor nutrients intake, including more intake of of sucrose and insufficient consumption of protein, fiber, eicosapentaenoic acid, niacin and vitamin B6.

The study also indicated that these nutrient inappropriate in patients with depression also expressed a lower quality of life in compared to control, by comprehensive geriatric assessment.

Other, in cross-sectional study conducted of the intake of major (that is, carbohydrates, fat, and protein) and minor (that is, vitamins and minerals) nutrients in adults with confirmed mood disorders, higher intake of nutrients are significant correlations to higher mental function and inversely associated to risk of mental disorder.

Mood disordered patients also showed a mild and moderated expression of depression, but not consistently.

Taking together, there is no doubt that deficiency of niacin other nutrients may exaggerated  the risk of depression.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression by Guligowska A1, Pigłowska M1, Fife E1, Kostka J2, Sołtysik BK1, Kroc Ł1, Kostka T1.(PubMed)
(2) Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders by Davison KM1, Kaplan BJ.(PubMed)