Ovarian cancer is the medical and chronic condition characterized by irregular cell growth in the tissues found either in at the tail ends of the fallopian tubes or the ovaries.
According to the statistics provided by the American Cancer Society, ovarian cancer is one of the dealy reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.
The lifetime risk of a woman getting ovarian cancer is 1/78 compared to the lifetime dying risk of 1/108.
The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.
The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, acquired genetic mutation such as TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.
Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, changes in bowel habits, such as constipation. and a frequent need to urinate.
In seeking a natural product that processes anti-ovarian cancer property, researchers examined the effects of 3,3'-diindolylmethane (DIM) on ovarian cancer cell viability, invasion, and sensitivity to chemotherapy.
According to the final results obtained by the ovarian cancer SKOV3 and A2780 cell lines treated by the 3,3'-diindolylmethane (DIM), DIM treatment not only potently suppressed the viabilities of ovarian cancer cells but also inhibited xenograft growth in nude mice.
Furthermore, according to the gene analysis, DIM inhibited phosphorylation of STAT3 and AKT proteins and proteins activated by STAT3 and AKT involved in cell growth and division and cell movement in the ovarian cancer SKOV3 and A2780 cell lines
Moreover, DIM inhibited the production of protein and genes associated with the production of a new blood vessel for the cancer cells to growth, promotion of cancer cell survival and anti-apoptosis.
Additionally, in order to obtain more information about DIM anti-ovarian cancer effects, researchers examined the phytochemical activity on Interleukin (IL6) which has been found to be a major contributor to the initiation and progression of ovarian cancer.
During the experiment, human ovarian carcinoma-derived cell lines SKOV3 and A2780 treated with IL6 and/or DIM and subjected to in vitro proliferation, DIM inhibited the increase of ovarian cancer cell adhesion, migration, and invasion caused by the administration of IL-6 through deactivated the expression of protein STAT3 similar to that of the aforementioned study.
Importantly, DIM induced ovarian cancer cells apoptosis associated with the inhibition of the expression matrix metalloproteinases MMP-2 and MMP-9 associated with the pathologic relationship to cancer.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo by Zou M1, Xu C2, Li H3, Zhang X4, Fan W. (PubMed)
(2) IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells by Zou M1, Zhang X2, Xu C. (PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Tuesday, December 31, 2019
Cooked Tomato's Lycopene Protects Protein, Lipid and Cell Damage Against Oxidative Stress in Human Studies
Oxidative stress is a condition characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
Antioxidant Indicaxanthin Inhibits Hypercholesterolemia and Hypercholesterolemic Complications
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to aging may have a strong impact on the increased incidence in the US.
Dr. Parini P, the lead scientist wrote, "Plasma cholesterol levels increase with age, as does the incidence of coronary heart disease" and "the relative deficiency in growth hormone (GH), which occurs with aging, contributes to the development of the age-related hypercholesterolemia because GH has beneficial effects on cholesterol metabolism".
However, researchers continued, "Growth hormone (GH), treatment strongly reduced the hypercholesterolemia in 18-month-old animals. We conclude that the age-dependent increase of plasma cholesterol in rats can be reversed by the administration of GH, presumably through the pleiotropic effects of this hormone on lipoprotein metabolism".
In other words, aging in the promotion of hypercholesterolemia induced complications can be preventable by the regulation of lipoprotein metabolism.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound for the improvement of cholesterol file, researchers examined the effect of Indicaxanthin effects on toxic oxysterols in hypercholesterolemia.
Where toxic oxysterols in hypercholesterolemia have been found to cause suicidal death of human erythrocytes or eryptosis associated with red blood cell programmed death.
According to the tested differentiation, indicaxanthin (Ind) from cactus pear fruit, incubated with isolated healthy human erythrocytes exposed to an oxysterol mixture for 48 h in a concentration range (1.0-5.0 μM) prevents membrane phosphatidylserine (PS) externalization and cell shrinkage in a dose-dependent manner.
In other words, indicaxanthin (Ind) protect the PS that regulates the production of thrombin, the central regulatory molecule of blood coagulation caused by overexpression of ROS and depletion of antioxidant enzymes and production of inflammatory cytokine-induced by an oxysterol mixture without affecting the erythrocyte redox environment or other parameters.
In ex vivo, indicaxanthin (Ind) at 5 μm, induced the spiking levels of normal human blood with the oxysterol mixture for 48 h induced eryptosis, by reducing the production of ROS and decreased levels of GSH.
Furthermore, eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling and red blood cell programmed death to cause vascular tissue injury was inhibited by 5 μm-Ind.
These results suggested that eryptotic erythrocytes that contribute to thrombotic complications in hypercholesterolemia were prevented by the application of indicaxanthin.
Based on the findings, researchers said, "the positive effects of diets containing Ind on erythrocytes in hypercholesterolaemic subjects".
Taken altogether, indicaxanthin may be considered a remedy for the prevention of hypercholesterolemia complications, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers by Tesoriere L1, Attanzio A1, Allegra M1, Livrea MA. (PubMed)
(2) Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats by Parini P1, Angelin B, Rudling M. (PubMed)
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to aging may have a strong impact on the increased incidence in the US.
Dr. Parini P, the lead scientist wrote, "Plasma cholesterol levels increase with age, as does the incidence of coronary heart disease" and "the relative deficiency in growth hormone (GH), which occurs with aging, contributes to the development of the age-related hypercholesterolemia because GH has beneficial effects on cholesterol metabolism".
However, researchers continued, "Growth hormone (GH), treatment strongly reduced the hypercholesterolemia in 18-month-old animals. We conclude that the age-dependent increase of plasma cholesterol in rats can be reversed by the administration of GH, presumably through the pleiotropic effects of this hormone on lipoprotein metabolism".
In other words, aging in the promotion of hypercholesterolemia induced complications can be preventable by the regulation of lipoprotein metabolism.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound for the improvement of cholesterol file, researchers examined the effect of Indicaxanthin effects on toxic oxysterols in hypercholesterolemia.
Where toxic oxysterols in hypercholesterolemia have been found to cause suicidal death of human erythrocytes or eryptosis associated with red blood cell programmed death.
According to the tested differentiation, indicaxanthin (Ind) from cactus pear fruit, incubated with isolated healthy human erythrocytes exposed to an oxysterol mixture for 48 h in a concentration range (1.0-5.0 μM) prevents membrane phosphatidylserine (PS) externalization and cell shrinkage in a dose-dependent manner.
In other words, indicaxanthin (Ind) protect the PS that regulates the production of thrombin, the central regulatory molecule of blood coagulation caused by overexpression of ROS and depletion of antioxidant enzymes and production of inflammatory cytokine-induced by an oxysterol mixture without affecting the erythrocyte redox environment or other parameters.
In ex vivo, indicaxanthin (Ind) at 5 μm, induced the spiking levels of normal human blood with the oxysterol mixture for 48 h induced eryptosis, by reducing the production of ROS and decreased levels of GSH.
Furthermore, eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling and red blood cell programmed death to cause vascular tissue injury was inhibited by 5 μm-Ind.
These results suggested that eryptotic erythrocytes that contribute to thrombotic complications in hypercholesterolemia were prevented by the application of indicaxanthin.
Based on the findings, researchers said, "the positive effects of diets containing Ind on erythrocytes in hypercholesterolaemic subjects".
Taken altogether, indicaxanthin may be considered a remedy for the prevention of hypercholesterolemia complications, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers by Tesoriere L1, Attanzio A1, Allegra M1, Livrea MA. (PubMed)
(2) Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats by Parini P1, Angelin B, Rudling M. (PubMed)
Phytochemical Alliin Inhibits the Onset of High Blood Pressure
High blood pressure, a condition characterized by elevated blood pressure in the arteries. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
In other words, the heart has to work harder to circulate blood to the body's needs in high blood pressure patients. Long-term d elevate blood pressure raises the pressure of the heart, leading to damage to the heart tissue in facilitating the risk of cardiovascular disease.
According to the statistics provided by the CDC, approximately 54% of adults in the US are living with high blood pressure and half of that have an uncontrol condition.
Believe it or not, in the US, high blood pressure is a major cause of heart disease and stroke and a leading cause of death.
Many factors have been found to increase the risk of high blood pressure, including, tobacco or excessive alcohol drinking, chronic medical conditions such as kidney disease, diabetes and sleep apnea.
Some researchers suggested that the promotion of the Western diet with high consumption of salt may have a strong effect on increasing the prevalence of high blood pressure over the past few decades.
Dr. the lead scientist wrote, "Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities".
And, "The World Health Organization (WHO) strongly recommended reducing dietary salt intake as one of the top priority actions to tackle the global non-communicable disease crisis and has urged member nations to take action to reduce population-wide dietary salt intake to decrease the number of deaths from hypertension, cardiovascular disease, and stroke".
In other words, by following a healthy diet and moderate exercise, high blood pressure is preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin)on blood pressure.
The study included rats fed either by a 2% high cholesterol diet with and without aqueous garlic powder extract given orally to rats on a daily basis for 6 weeks or control rats fed a normal diet.
Compared to elevated levels of cholesterol in the rat fed with cholesterol diet without garlic extract, rats fed with a high cholesterol diet mixed with garlic powder showed a significant reduction in their serum cholesterol levels.
The high blood pressure of rats induced by cholesterol diet was also inhibited by garlic powder.
In other words, the blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to other groups without affecting levels of glucose and protein.
Based on the results, researchers after taking other factors into account wrote, " garlic is beneficial in reducing...systolic blood pressure in hypercholesterolemic rats".
And, "Our experimental results show that garlic may beneficially affect two risk factors for... and hypertension".
Moreover, the Tel Aviv University study in the comparison of the effects of a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril and alliin and captopril suggested CPSSA in high dose significantly decreased blood pressure, triglycerides, and homocysteine concentrations compared to alliin with a slight effect on SBP and Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
More precisely, Dr. Oron-Herman M, the lead scientist wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".
Taken altogether, alliin may be considered supplements for the prevention and treatment of hypertension, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(3) Dietary Salt Intake and Hypertension by Sung Kyu Ha, M.D. (PMC)
In other words, the heart has to work harder to circulate blood to the body's needs in high blood pressure patients. Long-term d elevate blood pressure raises the pressure of the heart, leading to damage to the heart tissue in facilitating the risk of cardiovascular disease.
According to the statistics provided by the CDC, approximately 54% of adults in the US are living with high blood pressure and half of that have an uncontrol condition.
Believe it or not, in the US, high blood pressure is a major cause of heart disease and stroke and a leading cause of death.
Many factors have been found to increase the risk of high blood pressure, including, tobacco or excessive alcohol drinking, chronic medical conditions such as kidney disease, diabetes and sleep apnea.
Some researchers suggested that the promotion of the Western diet with high consumption of salt may have a strong effect on increasing the prevalence of high blood pressure over the past few decades.
Dr. the lead scientist wrote, "Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities".
And, "The World Health Organization (WHO) strongly recommended reducing dietary salt intake as one of the top priority actions to tackle the global non-communicable disease crisis and has urged member nations to take action to reduce population-wide dietary salt intake to decrease the number of deaths from hypertension, cardiovascular disease, and stroke".
In other words, by following a healthy diet and moderate exercise, high blood pressure is preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin)on blood pressure.
The study included rats fed either by a 2% high cholesterol diet with and without aqueous garlic powder extract given orally to rats on a daily basis for 6 weeks or control rats fed a normal diet.
Compared to elevated levels of cholesterol in the rat fed with cholesterol diet without garlic extract, rats fed with a high cholesterol diet mixed with garlic powder showed a significant reduction in their serum cholesterol levels.
The high blood pressure of rats induced by cholesterol diet was also inhibited by garlic powder.
In other words, the blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to other groups without affecting levels of glucose and protein.
Based on the results, researchers after taking other factors into account wrote, " garlic is beneficial in reducing...systolic blood pressure in hypercholesterolemic rats".
And, "Our experimental results show that garlic may beneficially affect two risk factors for... and hypertension".
Moreover, the Tel Aviv University study in the comparison of the effects of a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril and alliin and captopril suggested CPSSA in high dose significantly decreased blood pressure, triglycerides, and homocysteine concentrations compared to alliin with a slight effect on SBP and Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
More precisely, Dr. Oron-Herman M, the lead scientist wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".
Taken altogether, alliin may be considered supplements for the prevention and treatment of hypertension, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(3) Dietary Salt Intake and Hypertension by Sung Kyu Ha, M.D. (PMC)
Sinigrin May Be The Potential Anti Atherosclerosis Chemical Compound, According to Studies
Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increased the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis through lowering the low-density lipoproteins and mechanisms associated with the inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increased the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis through lowering the low-density lipoproteins and mechanisms associated with the inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Monday, December 30, 2019
Antioxidants Lycopene In reducing Risk of Rectal Cancer in Women
Cancer is a group of chronic and medical associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.
A primary tumor or original tumor is a tumor first arose and progression to yield a cancerous mass.
Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance and alter the metabolic pathways, leading to disordered and violent cellular behavior.
At the early stage, due to the small size of the tumor, most patients are asymptomatic.
Rectum formed part of the colon acts as a temporary storage site for feces, before eliminating them as feces.
Rectal cancer is a malignant tumor that starts from the cells on the surface of the inner lining of the tissues of the rectum.
Most common symptoms of rectum cancer are a change in your bowel habits, such as diarrhea, constipation or more frequent bowel movements, dark or red blood in the stool, mucus in stool, abdominal pain and painful bowel movements accompanied by the general symptoms found in other types of cancer.
The exact causes of rectum cancer are unidentified. However, rectum cancer shares the similar risk of factors of colorectal cancer, including the increase of age, family and personal history, unhealthy diets such as red meat and processed foods, physical inactivity, overweight or obesity, alcohol, and smoking.
Some researchers suggested that the promotion of a high-fat diet over the past few decades may be correlated to the increased risk of rectum cancer.
Dr. Teresa T. Fung, the lead scientist said, "Results from investigations using a priori dietary patterns (i.e., diet quality scores) and a posteriori methods, which identify existing eating patterns (i.e., principal component analysis), continue to support the benefits of a plant-based diet with some dairy as a means to lower the risk of colorectal cancer, whereas a diet high in meats, refined grains, and added sugar appears to increase risk".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of rectal cancer, researchers examined the role of lycopene as a chemopreventive agent.
The study included 952 rectal cancer cases and 1,205 controls of a population-based case-control study from Northern California and Utah conducted between September 1997 and February 2002.
According to the returned questionnaires based on the detailed diet history, medical history, and lifestyle factors,
* For women, the relative to the highest level of intake, low intake of dietary lycopene suggested that lycopene is associated with a reduced risk of rectal cancer with the odds ratio (OR) = 1.7. In other words, the risk of rectal cancer decreased depending linearly to the amount of dietary lycopene intake daily and regularly.
* Dietary antioxidants including lycopene were not associated with rectal cancer risk in men.
* Compared to lycopene dietary alpha-, beta-, and gamma-tocopherol were associated with an approximately two-fold increased risk of rectal cancer in women.
More precisely, not all members work synergistically to a reduced risk of rectal cancer.
Based on the findings, researchers wrote, "Associations differed by estrogen status for beta-carotene, lycopene, and vitamin E. These results suggest that ... lycopene may modestly reduce the risk of rectal cancer in women".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of rectal cancer in women, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidants, carotenoids, and risk of rectal cancer by Murtaugh MA1, Ma KN, Benson J, Curtin K, Caan B, Slattery ML. (PubMed)
(2) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(3) Dietary Patterns and the Risk of Colorectal Cancer by Teresa T. Fung
and Lisa S. Brown. (PMC)
A primary tumor or original tumor is a tumor first arose and progression to yield a cancerous mass.
Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance and alter the metabolic pathways, leading to disordered and violent cellular behavior.
At the early stage, due to the small size of the tumor, most patients are asymptomatic.
Rectum formed part of the colon acts as a temporary storage site for feces, before eliminating them as feces.
Rectal cancer is a malignant tumor that starts from the cells on the surface of the inner lining of the tissues of the rectum.
Most common symptoms of rectum cancer are a change in your bowel habits, such as diarrhea, constipation or more frequent bowel movements, dark or red blood in the stool, mucus in stool, abdominal pain and painful bowel movements accompanied by the general symptoms found in other types of cancer.
The exact causes of rectum cancer are unidentified. However, rectum cancer shares the similar risk of factors of colorectal cancer, including the increase of age, family and personal history, unhealthy diets such as red meat and processed foods, physical inactivity, overweight or obesity, alcohol, and smoking.
Some researchers suggested that the promotion of a high-fat diet over the past few decades may be correlated to the increased risk of rectum cancer.
Dr. Teresa T. Fung, the lead scientist said, "Results from investigations using a priori dietary patterns (i.e., diet quality scores) and a posteriori methods, which identify existing eating patterns (i.e., principal component analysis), continue to support the benefits of a plant-based diet with some dairy as a means to lower the risk of colorectal cancer, whereas a diet high in meats, refined grains, and added sugar appears to increase risk".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of rectal cancer, researchers examined the role of lycopene as a chemopreventive agent.
The study included 952 rectal cancer cases and 1,205 controls of a population-based case-control study from Northern California and Utah conducted between September 1997 and February 2002.
According to the returned questionnaires based on the detailed diet history, medical history, and lifestyle factors,
* For women, the relative to the highest level of intake, low intake of dietary lycopene suggested that lycopene is associated with a reduced risk of rectal cancer with the odds ratio (OR) = 1.7. In other words, the risk of rectal cancer decreased depending linearly to the amount of dietary lycopene intake daily and regularly.
* Dietary antioxidants including lycopene were not associated with rectal cancer risk in men.
* Compared to lycopene dietary alpha-, beta-, and gamma-tocopherol were associated with an approximately two-fold increased risk of rectal cancer in women.
More precisely, not all members work synergistically to a reduced risk of rectal cancer.
Based on the findings, researchers wrote, "Associations differed by estrogen status for beta-carotene, lycopene, and vitamin E. These results suggest that ... lycopene may modestly reduce the risk of rectal cancer in women".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of rectal cancer in women, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidants, carotenoids, and risk of rectal cancer by Murtaugh MA1, Ma KN, Benson J, Curtin K, Caan B, Slattery ML. (PubMed)
(2) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(3) Dietary Patterns and the Risk of Colorectal Cancer by Teresa T. Fung
and Lisa S. Brown. (PMC)
Antioxidant Indicaxanthin Processes Cytoprotective Effects
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Also, at this stage cancer cells can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Symptoms of cancer at this stage are totally depended on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive related cancers.
Cytotoxicity is a process to induce the toxic agent to kill cells including healthy cells and cancer cells.
Cytotoxic drugs or cytostatics are cytotoxic chemotherapy that destroys cancer cells. Cytotoxic drugs have been found to induce healthy and cancer cell apoptosis by inhibiting cell division. The chemo-drugs also are transported by the bloodstream to kill cancer cells a distance away in case of distant spreading.
Some herbal medicines and phytochemicals have also been found to induce a cytotoxic effect on cancer cells by exhibiting the production of free radical toxic activity and protecting the nearby healthy cells through their antioxidant activity.
Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.
People with a weakened immune function are at a higher risk of cancer, comapred to people with a normal or healthy immune system.
Dr. Candeias SM, the lead scientist said, "The immune system plays a pivotal role in the maintenance of the integrity of an organism. Besides the protection against pathogens, it is strongly involved in cancer prevention, development and defense".
And, "the immune system and developing tumors are intimately intertwined. Anti-tumor immune responses can be prominently boosted by multimodal therapies aiming at the one hand to induce immunogenic tumor cell death forms and on the other hand to actively counteract the immune suppressive microenvironment based on the tumor itself".
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound that processes cytoprotective activity, researchers examined the effect of Indicaxanthin effects on human beta-thalassemia RBCs.
In vitro, beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide was inhabited by the indicaxanthin at 1.0-10 microM by enhancing the resistance of the destruction of red blood cells in a dose-dependent manner.
Further, administration of indicaxanthin not only prevented lipid and hemoglobin (Hb) oxidation) to induce cell death but also restored the levels of vitamin E and GSH depletion which was retarded by oxidative hemolysis.
In vivo, indicaxanthin also improves the levels of blood from thalassemia patients by recovering the soluble cell compartment of the RBCs.
According to the spectrophotometric study, compared to Trolox or vitamin C, indicaxanthin are more effective in the inhibition of the preferred-Hb generated in solution induced by hydrogen peroxide (H2O2) in the diagnosis of anemia.
In other words, the phytochemical protects the quality and quantity of blood in human beta-thalassemia RBCs.
Based on the findings, researchers said, "indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation, possibly interfering with preferred-Hb, a reactive intermediate in the hydroperoxide-dependent Hb degradation".
Taken altogether, indicaxanthin may be considered a cytoprotective effects, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
(2) The Immune System in Cancer Prevention, Development and Therapy by Candeias SM1, Gaipl US. (PubMed)
Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Also, at this stage cancer cells can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Symptoms of cancer at this stage are totally depended on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive related cancers.
Cytotoxicity is a process to induce the toxic agent to kill cells including healthy cells and cancer cells.
Cytotoxic drugs or cytostatics are cytotoxic chemotherapy that destroys cancer cells. Cytotoxic drugs have been found to induce healthy and cancer cell apoptosis by inhibiting cell division. The chemo-drugs also are transported by the bloodstream to kill cancer cells a distance away in case of distant spreading.
Some herbal medicines and phytochemicals have also been found to induce a cytotoxic effect on cancer cells by exhibiting the production of free radical toxic activity and protecting the nearby healthy cells through their antioxidant activity.
Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.
People with a weakened immune function are at a higher risk of cancer, comapred to people with a normal or healthy immune system.
Dr. Candeias SM, the lead scientist said, "The immune system plays a pivotal role in the maintenance of the integrity of an organism. Besides the protection against pathogens, it is strongly involved in cancer prevention, development and defense".
And, "the immune system and developing tumors are intimately intertwined. Anti-tumor immune responses can be prominently boosted by multimodal therapies aiming at the one hand to induce immunogenic tumor cell death forms and on the other hand to actively counteract the immune suppressive microenvironment based on the tumor itself".
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound that processes cytoprotective activity, researchers examined the effect of Indicaxanthin effects on human beta-thalassemia RBCs.
In vitro, beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide was inhabited by the indicaxanthin at 1.0-10 microM by enhancing the resistance of the destruction of red blood cells in a dose-dependent manner.
Further, administration of indicaxanthin not only prevented lipid and hemoglobin (Hb) oxidation) to induce cell death but also restored the levels of vitamin E and GSH depletion which was retarded by oxidative hemolysis.
In vivo, indicaxanthin also improves the levels of blood from thalassemia patients by recovering the soluble cell compartment of the RBCs.
According to the spectrophotometric study, compared to Trolox or vitamin C, indicaxanthin are more effective in the inhibition of the preferred-Hb generated in solution induced by hydrogen peroxide (H2O2) in the diagnosis of anemia.
In other words, the phytochemical protects the quality and quantity of blood in human beta-thalassemia RBCs.
Based on the findings, researchers said, "indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation, possibly interfering with preferred-Hb, a reactive intermediate in the hydroperoxide-dependent Hb degradation".
Taken altogether, indicaxanthin may be considered a cytoprotective effects, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
(2) The Immune System in Cancer Prevention, Development and Therapy by Candeias SM1, Gaipl US. (PubMed)
Phytochemical Alliin Inhibits the Onset of Hypercholesterolemia
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. In patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence in the US.
Dr. Jeannie Chan, the lead scientist wrote, "ApoE deficient mice, generated by gene targeting, have a lipoprotein profile similar to humans in that most of the plasma cholesterol is carried on VLDL and IDL particles rather than HDL particles as in non-genetically modified mice. ApoE-/- mice have elevated levels of plasma cholesterol even on a chow diet and develop atherosclerotic lesions spontaneously. Advanced lesions with plaque rupture that resemble those in humans have frequently observed in apoE-/- mice fed an HCHF diet, and these mice are used for developing drugs to reduce atherosclerosis".
In other words, a high-fat diet promoted the genes associated with cholesterol secretion.
With an aim to find a potential ingredient for the treatment of hypercholesterolemia, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
New Zealand rabbits selected to the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the Western blot analysis, WGLL protected the heart by improving aortic and coronary flow.
WGLL was also found to inhibit the atherosclerotic plaque coverage.
Furthermore, WGLL also reduced the risk of hypercholesteremia by significantly reducing the plasma levels of low-density lipoprotein.
Based on the findings, researchers said, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered supplements for the prevention and treatment of heart disease associated with hypercholesterolemia, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Animal Models of Diet-induced Hypercholesterolemia By Jeannie Chan, Genesio M. Karere, Laura A. Cox and John L. VandeBerg.
In other words, the condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. In patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence in the US.
Dr. Jeannie Chan, the lead scientist wrote, "ApoE deficient mice, generated by gene targeting, have a lipoprotein profile similar to humans in that most of the plasma cholesterol is carried on VLDL and IDL particles rather than HDL particles as in non-genetically modified mice. ApoE-/- mice have elevated levels of plasma cholesterol even on a chow diet and develop atherosclerotic lesions spontaneously. Advanced lesions with plaque rupture that resemble those in humans have frequently observed in apoE-/- mice fed an HCHF diet, and these mice are used for developing drugs to reduce atherosclerosis".
In other words, a high-fat diet promoted the genes associated with cholesterol secretion.
With an aim to find a potential ingredient for the treatment of hypercholesterolemia, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
New Zealand rabbits selected to the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the Western blot analysis, WGLL protected the heart by improving aortic and coronary flow.
WGLL was also found to inhibit the atherosclerotic plaque coverage.
Furthermore, WGLL also reduced the risk of hypercholesteremia by significantly reducing the plasma levels of low-density lipoprotein.
Based on the findings, researchers said, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered supplements for the prevention and treatment of heart disease associated with hypercholesterolemia, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Animal Models of Diet-induced Hypercholesterolemia By Jeannie Chan, Genesio M. Karere, Laura A. Cox and John L. VandeBerg.
Phytochemical Sinigrin, the Potential Anti Tongue Cancer Bioactive Compound, Researchers Found
Scientists may have found a bioactive ingredient for the treatment of tongue cancer with no side effects, according to studies.
Tongue cancer is a medical condition caused by irregular cell growth in the tissue of the tongue, due to the alternation of cell DNA.
Most cases of tongue cancer begin in the cells on the surface of the inner lining of the tongue. At the early stage, tongue cancer patients may not experience any size due to the very small of the tumors.
However, at the advanced stage, patients may experience symptoms of the persistent tongue and/or jaw pain as the tumor has pressed on the nearby nerve cells, a lump or tumor inside the mouth. a white or red patch on the gums, tongue, tonsil or lining in the mouth and persistent sore throat and difficulty swallowing or chewing.
If you have some of the above symptoms, please make sure to check with your doctor to rule out the possibility.
There are many risk factors associated with the disease, including long-term use of tobacco, excessive alcohol drinking, sun exposure to your lips.
Some researchers suggested that sexually transmitted virus human papillomavirus (HPV) and people with a weakened immune system also have been found in patients with tongue cancer.
The Cleveland Clinic wrote in the article of Oropharyngeal Human Papilloma Virus (HPV) Infection
"Human papillomavirus (HPV), commonly known as the virus that causes genital warts and cervical cancer in women, is increasingly being recognized now as a cause of infections that colonize the back of the mouth (throat or oropharynx), including the tongue base and tonsils, and potentially a cause of cancer of the head and neck".
The results strongly suggested that people who carry the HPV virus in their mouth are at an increased risk of tongue cancer, compared to those without.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on the searching natural compound with the inhibitory activity against the tonguecarcinogenesis examined the effects of indole-3-carbinol (I3C) and sinigrin (SIN) on the initiation and post-initiation phases of tongue cancer.
Selected male ACI/N rats. induced tongue cancer by the injection of by 4-nitroquinoline 1-oxide (4-NQO) divided into
* Group 1 was given 4-NQO (10 ppm) in the drinking water for 12 weeks, starting at 7 weeks of age;
* Groups 2 and 3 were given 4-NQO and fed the diets containing I3C (1,000 ppm) and SIN (1,200 ppm) for 14 weeks, respectively, starting at 6 weeks of age;
* Groups 4 and 5 were given 4-NQO and then they were fed I3C and SIN containing diets for 23 weeks, respectively, starting one week after 4-NQO exposure;
* Groups 6 and 7 were given I3C and SIN alone, respectively, during the experiment; and
* Group 8 served as an untreated control.
At the end of the experiment at week 37, the incidence of tongue neoplasms (squamous cell papilloma and carcinoma) in group 2 (1/15, 7%), group 3 (1/15, 7%), group 4 (3/15, 20%) or group 5 (2/15, 13%) was significantly smaller than that in group 1 (12/17, 71%).
Group groups 2, 3, and 5 showed no tongue carcinomas developed. In other words, the injection of I3C and SIN restored the infected cell to healthy levels induced by the 4-NQO.
Group treated with I3C and SIN also showed reduced levels of the incidence of preneoplastic lesions such as hyperplasia and dysplasia.
In other words, I3C and SIN not only are effective against tongue cancer but also inhibit the progression of preneoplastic lesions of the tongue in group 2 (11/15, 73%), group 3 (10/15, 67%), group 4 (11/15, 73%) or group 5 (10/15, 67%) was significantly lower than that in group 1 (17/17, 100%) (P = 0.04 or P = 0.02).
Furthermore, There were no tongue neoplasms in rats of groups 6, 7, and 8.
Moreover, the Administration of I3C and SIN also caused significant decreases in the number and area of silver-stained nucleolar organizer regions protein (AgNORs) in the expression of in the tongue tumor pathology.
Dr. Tanaka T and colleagues wrote in the final report, " I3C and SIN inhibited rat tongue carcinogenesis in both the initiation and post-initiation phases, when administered in these respective phases together with, or following treatment with, 4-NQO".
Taken altogether, sinigrin (SIN) used alone or combined with I3C may be effective for the prevention and treatment of tongue cancer, pending to the confirmation of large sample size and multicenter human study.
Intake of SIN in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Tongue cancer is a medical condition caused by irregular cell growth in the tissue of the tongue, due to the alternation of cell DNA.
Most cases of tongue cancer begin in the cells on the surface of the inner lining of the tongue. At the early stage, tongue cancer patients may not experience any size due to the very small of the tumors.
However, at the advanced stage, patients may experience symptoms of the persistent tongue and/or jaw pain as the tumor has pressed on the nearby nerve cells, a lump or tumor inside the mouth. a white or red patch on the gums, tongue, tonsil or lining in the mouth and persistent sore throat and difficulty swallowing or chewing.
If you have some of the above symptoms, please make sure to check with your doctor to rule out the possibility.
There are many risk factors associated with the disease, including long-term use of tobacco, excessive alcohol drinking, sun exposure to your lips.
Some researchers suggested that sexually transmitted virus human papillomavirus (HPV) and people with a weakened immune system also have been found in patients with tongue cancer.
The Cleveland Clinic wrote in the article of Oropharyngeal Human Papilloma Virus (HPV) Infection
"Human papillomavirus (HPV), commonly known as the virus that causes genital warts and cervical cancer in women, is increasingly being recognized now as a cause of infections that colonize the back of the mouth (throat or oropharynx), including the tongue base and tonsils, and potentially a cause of cancer of the head and neck".
The results strongly suggested that people who carry the HPV virus in their mouth are at an increased risk of tongue cancer, compared to those without.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on the searching natural compound with the inhibitory activity against the tonguecarcinogenesis examined the effects of indole-3-carbinol (I3C) and sinigrin (SIN) on the initiation and post-initiation phases of tongue cancer.
Selected male ACI/N rats. induced tongue cancer by the injection of by 4-nitroquinoline 1-oxide (4-NQO) divided into
* Group 1 was given 4-NQO (10 ppm) in the drinking water for 12 weeks, starting at 7 weeks of age;
* Groups 2 and 3 were given 4-NQO and fed the diets containing I3C (1,000 ppm) and SIN (1,200 ppm) for 14 weeks, respectively, starting at 6 weeks of age;
* Groups 4 and 5 were given 4-NQO and then they were fed I3C and SIN containing diets for 23 weeks, respectively, starting one week after 4-NQO exposure;
* Groups 6 and 7 were given I3C and SIN alone, respectively, during the experiment; and
* Group 8 served as an untreated control.
At the end of the experiment at week 37, the incidence of tongue neoplasms (squamous cell papilloma and carcinoma) in group 2 (1/15, 7%), group 3 (1/15, 7%), group 4 (3/15, 20%) or group 5 (2/15, 13%) was significantly smaller than that in group 1 (12/17, 71%).
Group groups 2, 3, and 5 showed no tongue carcinomas developed. In other words, the injection of I3C and SIN restored the infected cell to healthy levels induced by the 4-NQO.
Group treated with I3C and SIN also showed reduced levels of the incidence of preneoplastic lesions such as hyperplasia and dysplasia.
In other words, I3C and SIN not only are effective against tongue cancer but also inhibit the progression of preneoplastic lesions of the tongue in group 2 (11/15, 73%), group 3 (10/15, 67%), group 4 (11/15, 73%) or group 5 (10/15, 67%) was significantly lower than that in group 1 (17/17, 100%) (P = 0.04 or P = 0.02).
Furthermore, There were no tongue neoplasms in rats of groups 6, 7, and 8.
Moreover, the Administration of I3C and SIN also caused significant decreases in the number and area of silver-stained nucleolar organizer regions protein (AgNORs) in the expression of in the tongue tumor pathology.
Dr. Tanaka T and colleagues wrote in the final report, " I3C and SIN inhibited rat tongue carcinogenesis in both the initiation and post-initiation phases, when administered in these respective phases together with, or following treatment with, 4-NQO".
Taken altogether, sinigrin (SIN) used alone or combined with I3C may be effective for the prevention and treatment of tongue cancer, pending to the confirmation of large sample size and multicenter human study.
Intake of SIN in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tonguecarcinogenesis by Tanaka T1, Kojima T, Morishita Y, Mori H. (PubMed)
(2) Oropharyngeal Human Papilloma Virus (HPV) Infection by (Cleveland Clinic)
Collard Greens Process Thrombolytic Activity
Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the recovery of vascular injury. However, overexpression of platelet counts in the blood is problematic to human health.
In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including
* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.
* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.
* Disorder of platelet secretion is a condition that causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.
* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.
Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.
Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".
These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
On finding a potential plant that process thrombolytic activity researchers compared the effects of
the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema Orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata L.
The study was conducted in vitro thrombolytic model with streptokinase as a positive control and water as a negative control.
Family of Brassica oleracea showed a range of clot lysis activity of 30.24 ± 0.95% compared to 46.44 ± 2.44% in T. Orientalis, 48.39 ± 10.12% in B. monnieri, 36.87 ± .27% in C. frutescens, and 47.89 ± 6.83% in U. sinuata, compared with positive control on standard streptokinase (80.77 ± 1.12%) and negative control on sterile distilled water (5.69 ± 3.09%).
Low-value clot lysis activity of the Family of Brassica oleracea was found associated with a lack of bio-active components and/or insufficient quantities in the extract.
According to the clot lysis results, chloroform soluble phytochemicals from these plants were found to contribute to the activity of thrombolysis.
Therefore, chloroform soluble phytochemicals isolated from these plants including the Family of Brassica oleracea may be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases.
Taken altogether, collard green consists of chloroform soluble phytochemicals that may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis by Emran TB1,2, Rahman MA3, Uddin MM4, Rahman MM5, Uddin MZ6, Dash R7, Layzu C. (PubMed)
In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including
* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.
* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.
* Disorder of platelet secretion is a condition that causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.
* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.
Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.
Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".
These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
On finding a potential plant that process thrombolytic activity researchers compared the effects of
the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema Orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata L.
The study was conducted in vitro thrombolytic model with streptokinase as a positive control and water as a negative control.
Family of Brassica oleracea showed a range of clot lysis activity of 30.24 ± 0.95% compared to 46.44 ± 2.44% in T. Orientalis, 48.39 ± 10.12% in B. monnieri, 36.87 ± .27% in C. frutescens, and 47.89 ± 6.83% in U. sinuata, compared with positive control on standard streptokinase (80.77 ± 1.12%) and negative control on sterile distilled water (5.69 ± 3.09%).
Low-value clot lysis activity of the Family of Brassica oleracea was found associated with a lack of bio-active components and/or insufficient quantities in the extract.
According to the clot lysis results, chloroform soluble phytochemicals from these plants were found to contribute to the activity of thrombolysis.
Therefore, chloroform soluble phytochemicals isolated from these plants including the Family of Brassica oleracea may be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases.
Taken altogether, collard green consists of chloroform soluble phytochemicals that may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis by Emran TB1,2, Rahman MA3, Uddin MM4, Rahman MM5, Uddin MZ6, Dash R7, Layzu C. (PubMed)
Sunday, December 29, 2019
Bioactive Compound Lycopene Inhibits the Onset and Progression Of Esophageal Cancer in Vitro
Esophagus, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is a medical condition that starts in the cells on the surface of the inner lining of the esophageal tissue caused by the alternation of cell DNA.
At the advanced stage, most cases of esophageal cancer after penetrating the wall of the esophagus tend to spread to the lymph node around the bottom of the esophagus, stomach and chest, then to the distant parts of the body.
According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.
Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.
The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.
2 common types of esophageal cancer are* Adenocarcinomas are the most common type of esophageal cancer in the United States, which occurred in the mucus-forming gland cells in the lower part of the esophagus.
* Squamous cancer occurs in the flat, thin cells that line the surface of the upper part of the esophagus.
Some researchers suggested that the risk of esophageal cancer can be reduced by
* Medicine
Taking medicine such as aspirin and other nonsteroidal anti-inflammatory drugs may reduce the risk of Esophageal cancer. Researchers at Fred Hutchinson Cancer Research Center suggested that aspirin and other nonsteroidal anti-inflammatory drugs disrupt the pathway, slow the growth of abnormal cells and facilitate the normal process of apoptosis.
* Quit-smoking and quit-heavy alcohol drinking
Heavy alcohol drinking and smoking account for over 90% of all squamous cancer.
* Avoid very hot foods
Food that is very hot can cause damage to the esophagus. Eating very hot foods for a prolonged period of time can cause an infection that leads to esophageal cancer.
* Reducing intake of fried, baked and roasted food
Fried, baked and roasted food contain acrylamide, a potentially cancer-causing carcinogenic chemical. In the animal lab, studies showed that large exposures to acrylamide may cause health problems, including damage to the nervous system and increased risk of cancer, including esophageal cancer.
* Maintaining a healthy weight
Researchers suggested that avoiding excessive weight gain and obesity may lower your risk of developing esophageal adenocarcinoma.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a natural compound for the treatment of esophageal cancer, researchers investigated the effect of lycopene and β-carotene on the viability of EC109 human esophageal squamous carcinoma cells.
According to the results from the tested assays, lycopene and β-carotene (5-40 µM) at a dose- and time-dependent showed a significant effect in reducing the viability of the EC109 cells.
Furthermore, lycopene and β-carotene also exhibited the enzyme expression of PPARγ associated with the inhibition of cancer migration and angiogenesis and protein p21 associated with cell cycle arrest and apoptosis regulation.
Moreover, lycopene and β-carotene also inhibited the protein associated with cell cycle division and tumor cell repopulation.
Based on the results, researchers said, " the inhibition of EC109 cell viability by lycopene and β-carotene involves PPARγ signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1, and COX-2 expression".
Additionally, in the study by the Zhejiang University to compare the higher intake of beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin reduced esophageal cancer risk, researchers found that * The pooled ORs of esophageal cancer risk are 0.58 (95% CI 0.44, 0.77), 0.81 (95% CI 0.70, 0.94), 0.75 (95% CI 0.64, 0.86), 0.80 (95% CI 0.66, 0.97), and 0.71 (95% CI 0.59, 0.87), respectively.
* Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer, and beta-carotene showed protective effects against esophageal adenocarcinoma in studies located in Europe and North America, according to the subgroup analysis.
Collectively, researchers wrote, " Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer. This meta-analysis suggested that higher intake of carotenoids (beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) is associated with a lower risk of esophageal cancer".
Taken altogether, lycopene used alone or combined with another herbal remedy may be considered supplements for the prevention and treatment of esophageal cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE. (PubMed)
(2) Carotenoid intake and esophageal cancer risk: a meta-analysis by Ge XX1, Xing MY, Yu LF, Shen P. (PubMed)
(3) Most common Types of Cancer -Cancer of Esophagus/Esophageal cancer by Kyle J. Norton
Esophageal cancer is a medical condition that starts in the cells on the surface of the inner lining of the esophageal tissue caused by the alternation of cell DNA.
At the advanced stage, most cases of esophageal cancer after penetrating the wall of the esophagus tend to spread to the lymph node around the bottom of the esophagus, stomach and chest, then to the distant parts of the body.
According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.
Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.
The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.
2 common types of esophageal cancer are* Adenocarcinomas are the most common type of esophageal cancer in the United States, which occurred in the mucus-forming gland cells in the lower part of the esophagus.
* Squamous cancer occurs in the flat, thin cells that line the surface of the upper part of the esophagus.
Some researchers suggested that the risk of esophageal cancer can be reduced by
* Medicine
Taking medicine such as aspirin and other nonsteroidal anti-inflammatory drugs may reduce the risk of Esophageal cancer. Researchers at Fred Hutchinson Cancer Research Center suggested that aspirin and other nonsteroidal anti-inflammatory drugs disrupt the pathway, slow the growth of abnormal cells and facilitate the normal process of apoptosis.
* Quit-smoking and quit-heavy alcohol drinking
Heavy alcohol drinking and smoking account for over 90% of all squamous cancer.
* Avoid very hot foods
Food that is very hot can cause damage to the esophagus. Eating very hot foods for a prolonged period of time can cause an infection that leads to esophageal cancer.
* Reducing intake of fried, baked and roasted food
Fried, baked and roasted food contain acrylamide, a potentially cancer-causing carcinogenic chemical. In the animal lab, studies showed that large exposures to acrylamide may cause health problems, including damage to the nervous system and increased risk of cancer, including esophageal cancer.
* Maintaining a healthy weight
Researchers suggested that avoiding excessive weight gain and obesity may lower your risk of developing esophageal adenocarcinoma.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a natural compound for the treatment of esophageal cancer, researchers investigated the effect of lycopene and β-carotene on the viability of EC109 human esophageal squamous carcinoma cells.
According to the results from the tested assays, lycopene and β-carotene (5-40 µM) at a dose- and time-dependent showed a significant effect in reducing the viability of the EC109 cells.
Furthermore, lycopene and β-carotene also exhibited the enzyme expression of PPARγ associated with the inhibition of cancer migration and angiogenesis and protein p21 associated with cell cycle arrest and apoptosis regulation.
Moreover, lycopene and β-carotene also inhibited the protein associated with cell cycle division and tumor cell repopulation.
Based on the results, researchers said, " the inhibition of EC109 cell viability by lycopene and β-carotene involves PPARγ signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1, and COX-2 expression".
Additionally, in the study by the Zhejiang University to compare the higher intake of beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin reduced esophageal cancer risk, researchers found that * The pooled ORs of esophageal cancer risk are 0.58 (95% CI 0.44, 0.77), 0.81 (95% CI 0.70, 0.94), 0.75 (95% CI 0.64, 0.86), 0.80 (95% CI 0.66, 0.97), and 0.71 (95% CI 0.59, 0.87), respectively.
* Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer, and beta-carotene showed protective effects against esophageal adenocarcinoma in studies located in Europe and North America, according to the subgroup analysis.
Collectively, researchers wrote, " Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer. This meta-analysis suggested that higher intake of carotenoids (beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) is associated with a lower risk of esophageal cancer".
Taken altogether, lycopene used alone or combined with another herbal remedy may be considered supplements for the prevention and treatment of esophageal cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE. (PubMed)
(2) Carotenoid intake and esophageal cancer risk: a meta-analysis by Ge XX1, Xing MY, Yu LF, Shen P. (PubMed)
(3) Most common Types of Cancer -Cancer of Esophagus/Esophageal cancer by Kyle J. Norton
Phytochemical Indicaxanthin Exerts a Strong Vascular Protective Effect
Blood vessels formed part of the circulatory system that transports blood throughout the body. Arteries and veins are the types of blood vessels that carry blood away from or towards the heart, respectively.
The 3 main types of blood vessels are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body.
Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.
Most cases of coronary artery disease are associated with cholesterol building up on the arterial wall found in patients with hypercholesterolemia.
The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.
Vascular dysfunction associated with dysfunction of large arteries, the microcirculation and endothelium have been found to induce the substantial risk of cardiovascular disease.
Vascular inflammation that causes reduced blood flow to the body due to the changes in the blood vessel walls, including thickening, weakening, narrowing or scarring is also one of the most common cardiovascular risk factors associated with patients with atherosclerosis and hypertension.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound that processes protective vascular effects, researchers examined the effect of Indicaxanthin, a natural chemo active and chemo preventive agent anti-inflammatory activity, against oxLDL-induced endothelial dysfunction.
According to the results of human umbilical vein cord cells (HUVEC) induced human oxLDL, pretreatment of indicaxanthin in a range between 5 and 20 μM, showed significant inhibition of oxLDL-induced cytotoxicity in a concentration-dependent manner.
Circulating vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) to serve as molecular markers of atherosclerosis and predictors of incident CHD were a significant increase and ABCA1gened associated with the regulation of cellular cholesterol was significantly decreased in the human oxLDL group compared to pretreatment group.
In other words, the phytochemical exerted protective vascular effects against the incidence of atherosclerosis caused by oxLDL through its antioxidants and anti-inflammatory expression.
Based on the findings, researchers said, "indicaxanthin as a novel, dietary phytochemicals, able to exert significant protective vascular effects in vitro, at nutritionally relevant concentrations".
Taken altogether, indicaxanthin may be considered a protective vascular remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indicaxanthin from Opuntia ficus indica (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-κB Activation by Attanzio A1, Frazzitta A1, Busa' R1, Tesoriere L1, Livrea MA1, Allegra M. (PubMed)
The 3 main types of blood vessels are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body.
Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.
Most cases of coronary artery disease are associated with cholesterol building up on the arterial wall found in patients with hypercholesterolemia.
The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.
Vascular dysfunction associated with dysfunction of large arteries, the microcirculation and endothelium have been found to induce the substantial risk of cardiovascular disease.
Vascular inflammation that causes reduced blood flow to the body due to the changes in the blood vessel walls, including thickening, weakening, narrowing or scarring is also one of the most common cardiovascular risk factors associated with patients with atherosclerosis and hypertension.
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
On finding a potential compound that processes protective vascular effects, researchers examined the effect of Indicaxanthin, a natural chemo active and chemo preventive agent anti-inflammatory activity, against oxLDL-induced endothelial dysfunction.
According to the results of human umbilical vein cord cells (HUVEC) induced human oxLDL, pretreatment of indicaxanthin in a range between 5 and 20 μM, showed significant inhibition of oxLDL-induced cytotoxicity in a concentration-dependent manner.
Circulating vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) to serve as molecular markers of atherosclerosis and predictors of incident CHD were a significant increase and ABCA1gened associated with the regulation of cellular cholesterol was significantly decreased in the human oxLDL group compared to pretreatment group.
In other words, the phytochemical exerted protective vascular effects against the incidence of atherosclerosis caused by oxLDL through its antioxidants and anti-inflammatory expression.
Based on the findings, researchers said, "indicaxanthin as a novel, dietary phytochemicals, able to exert significant protective vascular effects in vitro, at nutritionally relevant concentrations".
Taken altogether, indicaxanthin may be considered a protective vascular remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indicaxanthin from Opuntia ficus indica (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-κB Activation by Attanzio A1, Frazzitta A1, Busa' R1, Tesoriere L1, Livrea MA1, Allegra M. (PubMed)
Bioactive Compound Betanin Kills Chronic Myeloid Leukemia Cells in Vitro
Chronic myeloid leukemia (CML) is a medical condition associated with the overgrowth of immature cells that started in the blood-forming cells of the bone marrow.
In other words, compared to normal cells that will die after a limited cell division, chronic myeloid leukemia cells continue to divide with no meaning of dying or stopping, leading to proliferation that affects other healthy cells in the bone marrow.
At the advanced stage, chronic myeloid leukemia cell can leak to the bloodstream, leading to secondary metastasis, depending on the infected tissues and organs.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women. and CML is expected to cause the death of 1,140 people including 660 men and 480 women.
More precisely, CML accounts for 15% of all cases of leukemia diagnosed each year. In other words, the lifetime risk of CML in the US is 1 person in 526.
The 5-year survival rate of patients treated with chemo drug imatinib (Gleevec®) including all stages of CML is 90%.
Although the increased with age and male gender are 2 of factors involved in the onset of the condition, some researchers suggested genetic proposition also plays a critical role in increasing risk
of CML.
The Bethesda (MD): National Center for Biotechnology Information (US); 1998, wrote in the book of "Genes and Disease", "A mouse model has been created that develops a CML-like disease when given bone marrow cells infected with a virus containing the BCR-ABL gene. In other animal models, the fusion proteins have been shown to transform normal blood precursor cells to malignant cells".
And, "To research the human disease, antisense oligomers (short DNA segments) that block BCR-ABL were developed that specifically suppressed the formation of leukemic cells while not affecting the normal bone marrow cell development. These and other experimental techniques may lead to future treatments for CML".
The findings suggested that people with certain gene mutation are prone to the development of CML compared to those do not.
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find natural ingredients for the treatment of chronic myeloid leukemia, researchers investigated the antiproliferative effects of betanin, a principle betacyanin pigment, on the human chronic myeloid leukemia cell line (K562).
Administration of betanin decreased the proliferation of K562 cells with an IC(50) of 40 microM in a dose and time-dependent manner.
According to the scanning and transmission electron microscopy, betanin induced cancer cell death by the pro-apoptotic characteristics of chromatin condensation, cell shrinkage and membrane blebbing.
Chronic myeloid leukemia cell line (K562) treated by betanin also showed a fragmentation pattern typical for apoptotic cells.
Observed by the flow cytometric analysis, cancer cells treated with 40 microM of betanin showed 28.4% of cells in the sub G0/G1 phase, an indication of cell cycle arrest.
According to the confocal microscopic studies, betanin inhibited the expression of the chronic myeloid leukemia cell line (K562)by gaining entry directly into the cells.
Based on the finding, researchers suggested that betanin induced chronic myeloid leukemia cell line (K562) death within the cell such as inducing the release of cytochrome c from mitochondria into the cytosol.
Taken altogether, betanin may be considered supplements for the prevention and treatment of chronic myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562 by Sreekanth D1, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. (PubMed)
(2) Genes and Disease by National Center for Biotechnology Information (US), Bethesda (MD): National Center for Biotechnology Information (US); 1998. (NCBI)
In other words, compared to normal cells that will die after a limited cell division, chronic myeloid leukemia cells continue to divide with no meaning of dying or stopping, leading to proliferation that affects other healthy cells in the bone marrow.
At the advanced stage, chronic myeloid leukemia cell can leak to the bloodstream, leading to secondary metastasis, depending on the infected tissues and organs.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women. and CML is expected to cause the death of 1,140 people including 660 men and 480 women.
More precisely, CML accounts for 15% of all cases of leukemia diagnosed each year. In other words, the lifetime risk of CML in the US is 1 person in 526.
The 5-year survival rate of patients treated with chemo drug imatinib (Gleevec®) including all stages of CML is 90%.
Although the increased with age and male gender are 2 of factors involved in the onset of the condition, some researchers suggested genetic proposition also plays a critical role in increasing risk
of CML.
The Bethesda (MD): National Center for Biotechnology Information (US); 1998, wrote in the book of "Genes and Disease", "A mouse model has been created that develops a CML-like disease when given bone marrow cells infected with a virus containing the BCR-ABL gene. In other animal models, the fusion proteins have been shown to transform normal blood precursor cells to malignant cells".
And, "To research the human disease, antisense oligomers (short DNA segments) that block BCR-ABL were developed that specifically suppressed the formation of leukemic cells while not affecting the normal bone marrow cell development. These and other experimental techniques may lead to future treatments for CML".
The findings suggested that people with certain gene mutation are prone to the development of CML compared to those do not.
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find natural ingredients for the treatment of chronic myeloid leukemia, researchers investigated the antiproliferative effects of betanin, a principle betacyanin pigment, on the human chronic myeloid leukemia cell line (K562).
Administration of betanin decreased the proliferation of K562 cells with an IC(50) of 40 microM in a dose and time-dependent manner.
According to the scanning and transmission electron microscopy, betanin induced cancer cell death by the pro-apoptotic characteristics of chromatin condensation, cell shrinkage and membrane blebbing.
Chronic myeloid leukemia cell line (K562) treated by betanin also showed a fragmentation pattern typical for apoptotic cells.
Observed by the flow cytometric analysis, cancer cells treated with 40 microM of betanin showed 28.4% of cells in the sub G0/G1 phase, an indication of cell cycle arrest.
According to the confocal microscopic studies, betanin inhibited the expression of the chronic myeloid leukemia cell line (K562)by gaining entry directly into the cells.
Based on the finding, researchers suggested that betanin induced chronic myeloid leukemia cell line (K562) death within the cell such as inducing the release of cytochrome c from mitochondria into the cytosol.
Taken altogether, betanin may be considered supplements for the prevention and treatment of chronic myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562 by Sreekanth D1, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. (PubMed)
(2) Genes and Disease by National Center for Biotechnology Information (US), Bethesda (MD): National Center for Biotechnology Information (US); 1998. (NCBI)
Herbal Ashwagandha Reduces the Risk of Memory Loss
Memory is one of the major function of the brain that collects and stores data or information which are retrieved when needed.
In other words, memory is the retention of information over time that have a strong influence on future action.
Memory impairment is a condition of partial or complete loss of memory, depending on the quality of the neuron that has been affected.
Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.
Memory impairment can be acute or chronic.
In acute impairment, memory is temporary loss in most cases associated with physical impact on the brain that causes injury of neurons.
Chronic memory impairment is the loss of memory that can get worse overtime found mostly in the elderly with neurodegenerative diseases, such as dementia.
In elderly or aging-induced memory loss are associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.
The most common risk factors associated with memory loss in the general population are long-term use of certain medications, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.
However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.
Dr. Scott E. Kanoski, the lead scientist in the review of the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".
And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".
The results clearly stated if you are a Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) on memory and cognitive functioning in adults with mild cognitive impairment (MCI).
The prospective, randomized, double-blind, placebo-controlled study included 50 adults assigned to the treatment of either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.
According to the analysis of Wechsler Memory Scale III subtest scores for logical memory, at week 8, the ashwagandha treatment group exerted significant improvements in both immediate and general memory, compared with the placebo group.
Futhermore, verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006) scores were also significantly increase compared to placebo.
According to the scores of Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009), ashwagandha treatment group also displayed a significantly greater improvement in executive function, sustained attention, and information-processing speed also compared to placebo.
Based on the findings, researchers said, "Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.".
Taken altogether, Ashwagandha may be considered a functional herb for the improvement of the brain health, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions by Choudhary D1, Bhattacharyya S2, Bose S. (PubMed)
(2) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)
In other words, memory is the retention of information over time that have a strong influence on future action.
Memory impairment is a condition of partial or complete loss of memory, depending on the quality of the neuron that has been affected.
Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.
Memory impairment can be acute or chronic.
In acute impairment, memory is temporary loss in most cases associated with physical impact on the brain that causes injury of neurons.
Chronic memory impairment is the loss of memory that can get worse overtime found mostly in the elderly with neurodegenerative diseases, such as dementia.
In elderly or aging-induced memory loss are associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.
The most common risk factors associated with memory loss in the general population are long-term use of certain medications, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.
However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.
Dr. Scott E. Kanoski, the lead scientist in the review of the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".
And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".
The results clearly stated if you are a Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) on memory and cognitive functioning in adults with mild cognitive impairment (MCI).
The prospective, randomized, double-blind, placebo-controlled study included 50 adults assigned to the treatment of either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.
According to the analysis of Wechsler Memory Scale III subtest scores for logical memory, at week 8, the ashwagandha treatment group exerted significant improvements in both immediate and general memory, compared with the placebo group.
Futhermore, verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006) scores were also significantly increase compared to placebo.
According to the scores of Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009), ashwagandha treatment group also displayed a significantly greater improvement in executive function, sustained attention, and information-processing speed also compared to placebo.
Based on the findings, researchers said, "Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.".
Taken altogether, Ashwagandha may be considered a functional herb for the improvement of the brain health, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions by Choudhary D1, Bhattacharyya S2, Bose S. (PubMed)
(2) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)
Cranberry, the Best in the Management of Obesity, Researchers Say
Obesity is a chronic condition characterized by excess body fat that has accumulated over time. People with a BMI of over 30 is considered obese.
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, over 30 % of the American population is obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Dr. EunSeok Cha, the lead scientist wrote, "Obesity among young adults is a growing problem in the United States and is related to unhealthy lifestyle habits such as high caloric intake and inadequate exercise. Accurate assessment of lifestyle habits across obesity stages is important for informing age-specific intervention strategies to prevent and reduce obesity progression".
And, "Overweight and obese young adults can promote their cardiometabolic health with healthy lifestyles. To take action, young adults need practical and strategic dietary advice about beverage choices, diet quality, and macronutrient and micronutrient sources. In addition, increasing overall activity and minimizing sedentary behavior needs to be emphasized for young adults to achieve physical activity goals.".
In other words, by changing to a healthy lifestyle such as healthy diet and moderate exercise, over a long-term obese is controllable.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers investigated the anti-adipogenic effect of the polyphenol-rich extract obtained from chokeberry Aronia melanocarpa (Michx.) Elliot, raspberry Rubus idaeus L., bilberry Vaccinium myrtillus L., and cranberry Vaccinium macrocarpon Aiton fruits.
According to the results from the analysis, the preparations ranged from 25-100 μg/mL not only significantly decreased lipid accumulation but also inhibited the expression of reactive oxygen species in the adipocytes without showing cytotoxicity.
The Real-time PCR analysis also revealed that the extract at a concentration of 100 μg/mL suppressed the process of cell differentiation of adipogenesis and lipogenesis that converts triglyceride for storage in fat via inhibiting the gene expression (PPARγ) of energy metabolism and genes associated with adipogenesis (C/EBPα) and lipogenesis (SREBP1).
In 3T3-L1 adipocytes, the expression of adiponectin involved in regulating glucose levels as well as fatty acid breakdown was increased by 4.4 fold whereas hormone leptin found in high levels of obese subjects was decreased by 90% by the extracts.
Based on the findings, researchers said, " the analyzed extract may be a promising source of bioactive compounds that support long-term weight maintenance and promote the effective management of obesity".
Taken altogether, cranberry combined with other herbal medicine may be considered a remedy for the management of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells by Kowalska K1, Olejnik A1, Szwajgier D2, Olkowicz M. (PubMed)
(2) Lifestyle habits and obesity progression in overweight and obese American young adults: Lessons for promoting cardiometabolic health by EunSeok Cha, PhD, MPH, MSN, CDE, RN, Margeaux K. Akazawa, MPH, Kevin H. Kim, PhD,*Colleen R. Dawkins, MSN, FNP-BC, RD, Hannah M. Lerner, BS, Guillermo Umpierrez, MD, FACP, FACE, and Sandra B. Dunbar, PhD, FAAN, FAHA, RN. (PMC)
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, over 30 % of the American population is obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Dr. EunSeok Cha, the lead scientist wrote, "Obesity among young adults is a growing problem in the United States and is related to unhealthy lifestyle habits such as high caloric intake and inadequate exercise. Accurate assessment of lifestyle habits across obesity stages is important for informing age-specific intervention strategies to prevent and reduce obesity progression".
And, "Overweight and obese young adults can promote their cardiometabolic health with healthy lifestyles. To take action, young adults need practical and strategic dietary advice about beverage choices, diet quality, and macronutrient and micronutrient sources. In addition, increasing overall activity and minimizing sedentary behavior needs to be emphasized for young adults to achieve physical activity goals.".
In other words, by changing to a healthy lifestyle such as healthy diet and moderate exercise, over a long-term obese is controllable.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers investigated the anti-adipogenic effect of the polyphenol-rich extract obtained from chokeberry Aronia melanocarpa (Michx.) Elliot, raspberry Rubus idaeus L., bilberry Vaccinium myrtillus L., and cranberry Vaccinium macrocarpon Aiton fruits.
According to the results from the analysis, the preparations ranged from 25-100 μg/mL not only significantly decreased lipid accumulation but also inhibited the expression of reactive oxygen species in the adipocytes without showing cytotoxicity.
The Real-time PCR analysis also revealed that the extract at a concentration of 100 μg/mL suppressed the process of cell differentiation of adipogenesis and lipogenesis that converts triglyceride for storage in fat via inhibiting the gene expression (PPARγ) of energy metabolism and genes associated with adipogenesis (C/EBPα) and lipogenesis (SREBP1).
In 3T3-L1 adipocytes, the expression of adiponectin involved in regulating glucose levels as well as fatty acid breakdown was increased by 4.4 fold whereas hormone leptin found in high levels of obese subjects was decreased by 90% by the extracts.
Based on the findings, researchers said, " the analyzed extract may be a promising source of bioactive compounds that support long-term weight maintenance and promote the effective management of obesity".
Taken altogether, cranberry combined with other herbal medicine may be considered a remedy for the management of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells by Kowalska K1, Olejnik A1, Szwajgier D2, Olkowicz M. (PubMed)
(2) Lifestyle habits and obesity progression in overweight and obese American young adults: Lessons for promoting cardiometabolic health by EunSeok Cha, PhD, MPH, MSN, CDE, RN, Margeaux K. Akazawa, MPH, Kevin H. Kim, PhD,*Colleen R. Dawkins, MSN, FNP-BC, RD, Hannah M. Lerner, BS, Guillermo Umpierrez, MD, FACP, FACE, and Sandra B. Dunbar, PhD, FAAN, FAHA, RN. (PMC)
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