Collard Greens Process Thrombolytic Activity

Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the recovery of vascular injury. However, overexpression of platelet counts in the blood is problematic to human health.

In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition that causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".


These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.


Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On finding a potential plant that process thrombolytic activity researchers compared the effects of
the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema Orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata L.
The study was conducted in vitro thrombolytic model with streptokinase as a positive control and water as a negative control.

Family of Brassica oleracea showed a range of clot lysis activity of 30.24 ± 0.95% compared to 46.44 ± 2.44% in T. Orientalis, 48.39 ± 10.12% in B. monnieri, 36.87 ± .27% in C. frutescens, and 47.89 ± 6.83% in U. sinuata, compared with positive control on standard streptokinase (80.77 ± 1.12%) and negative control on sterile distilled water (5.69 ± 3.09%).

Low-value clot lysis activity of the Family of Brassica oleracea was found associated with a lack of bio-active components and/or insufficient quantities in the extract.

According to the clot lysis results, chloroform soluble phytochemicals from these plants were found to contribute to the activity of thrombolysis.

Therefore, chloroform soluble phytochemicals isolated from these plants including the Family of Brassica oleracea may be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases.


Taken altogether, collard green consists of chloroform soluble phytochemicals that may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis by Emran TB1,2, Rahman MA3, Uddin MM4, Rahman MM5, Uddin MZ6, Dash R7, Layzu C. (PubMed)