The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.
Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.
Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of inflammatory cytokines to kill off micro-organisms that affect the function of the brain, leading to symptoms of fever, redness, and swelling.
Most cases of acute neuroinflammatory may be resolved within a few days without causing damage to the brain tissues. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic neuroinflammatory diseases.
Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.
Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"
And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of neurological disease, researchers examined the efficacy of a classical LPS model included aromatic-turmerone on neuroinflammation.
On LPS-induced neuroinflammation mice and BV2 cells, according to the tested analysis, oral administration of aromatic-turmerone not only reversed LPS-induced memory disturbance but also normalized glucose intake and metabolism in the brains.
The application of the aromatic-turmerone also protected the neuron viability by significantly limited brain damage by inhibiting the generation of inflammatory cytokines.associated with neuro-inflammation and activation of microglia involved in the immune system response to the LPS injection.
In vitro, aromatic-turmerone also targeted Toll-like receptor 4 which plays a key role in the innate immune system.in the mediation of downstream signaling associated with the activation of inflammatory mediators.
Based on the results, researchers said, "aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation and may be useful in the treatment of neuronal inflammatory diseases."
Taken altogether, turmeric may be considered supplements for the prevention and treatment of neuronal inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway by Chen M1, Chang YY1, Huang S1, Xiao LH1, Zhou W1, Zhang LY1, Li C1, Zhou RP2, Tang J3, Lin L4, Du ZY1, Zhang K. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)
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