Herbal Turmeric Inhibits the Ischemia/Reperfusion (I/R) Injury In the Liver

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

Liver cancer is a chronic liver disease associated with irregular cell growth that starts in the cells on the surface of the liver's inner lining tissue, before penetrating into deeper layers to form tumors through cell proliferation.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some form of liver disease.

Believe it or not, 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

The most common signs and symptoms of liver disease are jaundice, abdominal pain, and swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool and tendency to bruise easily.

If you have experienced some of the aforementioned symptoms that do not heal in a short period of time, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound that processes the liver-protective effects, researchers examined the efficacy of curcumin on liver ischemia/reperfusion (I/R) injury.

According to the analysis, curcumin protects the liver by reducing the liver oxidative stress and inflammation that can lead to ischemia-reperfusion injury in hepatic surgery and transplantation

Furthermore, mitochondria dysfunction associated with abnormal cell metabolism e in the liver, and liver Kupffer cells (KCs) activation associated with liver inflammation that causes IR were also inhibited by the injection of curcumin.

Vascular cell adhesion molecule overexpression and polymorphonuclear neutrophil injury-induced inflammation and immune-inflammatory response induced liver injury were also decreased by the curcumin administration.

Moreover, the efficacy of curcumin in the protection of the liver through the aforementioned activity was also found to be associated with the suppression of pathways in the reduction of liver ischemia-reperfusion injury.

Based on the findings researchers said, "This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention against ischemia-reperfusion injury, pending to the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of curcumin against ischemia-reperfusion injury in the liver by Bavarsad K1, Riahi MM2, Saadat S1, Barreto G3, Atkin SL4, Sahebkar A. (PubMed)