Sinigrin, the Potential Alternative Antibiotic for Fungal Infection, Scientists Say

The bioactive compound Sinigrin may be used as antibiotics for the treatment of fungal infection, studies suggested.

Antibiotics are conventional medicine used for the treatment of microbial infection except for virus.

Fungi are a kind of living organism, including molds, molds, and mushrooms.

Most cases of fungal infections start in the lungs or on the skin. People with the weakened immune system or long-term use of antibiotics and immune-suppressive medicine are prone to getting a fungal infection.

Histoplasmosis, which is the most common fungal infection in the US, caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.

However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis were diagnosed in the US each year.


Believe it or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.

Most cases of fungal infection are treated with antibiotics topically or orally.

The untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on types of fungal infection.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers with an aim to find a natural ingredient used by traditional medicine for the treatment of fungal infection investigated the effect of sinigrin in form of isothiocyanates (ITCs)against Alternaria brassicicola.

Exposure of the fungus to ICTs led to apoptosis through the decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS) and mitochondrial membrane depolarization.

The effects of fungal-induced infection on the activation of the mitogen-activated protein (MAP) kinase signaling pathway involved in directing cellular responses to a diverse array of stimuli, were inhibited by the presence of ICTs.

The injection of ICTs also induced the expression of oxygen reactive species in killing the fungi through cytotoxicity.

However, ICT-derived ROS was also countered by the expression of different oxidative-response genes stimulated by the Alternaria brassicicola.

The findings strongly suggested that ITCs exert their toxicity on fungal cells.

Taken altogether, sinigrin in form of isothiocyanates (ITCs) may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of larger sample size and multicenter human study.

Intake of sinigrin as a supplement should be taken with extreme care to prevent overdose-induced liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery by Benoit Calmes,1,† Guillaume N’Guyen,1,† Jérome Dumur,1 Carlos A. Brisach,1Claire Campion,1 Béatrice Iacomi,2 Sandrine Pigné,2 Eva Dias,1 David Macherel,1Thomas Guillemette,1 and Philippe Simoneau. (PMC)