Herbal Turmeric Protects the Neurons Integrity Against Neurodegeneration

Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.

Neurodegeneration is a condition associated with the gradual loss of neuron function caused by reduced quality and death of the neurons.

Neuroprotection is a process in which medicines or substances are used, including herbal remedy to protect the brain cell integrity against the damage and gradual loss of quality and quantity.

Most cases of neurodegenerative diseases are found in the elderly, including Parkinson's disease, Alzheimer's disease, and Huntington's disease.

According to the statistics, Alzheimers' disease and Parkinson's disease are the most common types of neurodegenerative diseases that affect millions of people worldwide.

In the US, approximately, over five million Americans living with Alzheimer's disease, and at least 500,000 Americans living with Parkinson's disease.

The most common risk factor associated with the onset of the neurodegenerative disease is aging. The rise of neurodegenerative disease in the US was probably associated with population-wide health improvements in the increased lifespan, along with a larger generation of aging Americans.

Conventionally, there is no cure for neurodegenerative disease.


The aim of the treatment is to relieve some of the physical or mental symptoms and slow down the progression of the disease accompanied by improving the quality of life of the patients and caregivers.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of neurodegeneration found a high percentage in elderly, researchers investigated the protective effects of a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, on dysmetabolism and neurodegeneration in an animal model.

The experiment included mice induced neurodegeneration by a high-fat diet (HFD).

NDS treatment mice showed significant prevention of against brain lipid accumulation and central insulin resistance by decreasing the cholesterol concentration and increasing in the insulin receptor expression and insulin signaling activation.

Furthermore, NDS also protected the brain cell by protecting the function of enzymes FACL-4 (Acyl-CoA synthetase 4), CerS-1, CerS-4 (Ceramides) whose expression were decreased due to high-fat diet against the onset of neurodegeneration.

Compared to untreated mice, NDS-treated HFD mice attenuated the levels of RNS, ROS, and lipid peroxidation in the brain.

In other words, NDS prevent the accumulation of lipid peroxidation in the neurons, the action can lead to cell death gradually.


Also, in the brain, NDS inhibited the overexpression of proteins associated with pro-infallamtory cytokine and free radicals caused by a high-fat diet in the induction of cell death, compared to untreated mice.


Additionally different of the results, researchers also found that a lower number of apoptotic nuclei was found in cortical sections of NDS-treated HFD mice, compared to untreated mice.


Dr. the lead scientist, after taking into account co and confounders wrote, "The present data indicate that NDS exerts neuroprotective effects in HFD mice by reducing brain fat accumulation, oxidative stress and inflammation and improving brain insulin resistance".

Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of neurodegeneration, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration by Di Martino RMC1,2, Bisi A1, Rampa A1, Gobbi S1, Belluti F. (PubMed)
(2) A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice by Nuzzo D1, Amato A2, Picone P3, Terzo S4, Galizzi G5, Bonina FP6, Mulè F7, Di Carlo M. (PubMed)