Broccoli' Sulforaphane (SF) In the Prevention of Colitis

Colitis is a medical condition of inflammation of the large intestine, including the colon, caecum, and rectum.

Types of colitis according to the Catholic University of the Sacred Heart, are including
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.


There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

The most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

The most common risk factors associated with the onset of colitis are Medical conditions such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation aging, genders, smoking, depression, and psychosocial stress and family history.

Other risk factors may also contribute to the incidence of colitis, according to the study by Service d'Epidémiologie et de Santé Publique, in a multivariate model are familial history of inflammatory bowel disease (odds ratio (OR) 4.3 (95% confidence interval 2.3-8)), breastfeeding (OR 2.1 (1.3-3.4)), bacille Calmette-Guerin vaccination (OR 3.6 (1.1-11.9)), and history of eczema (OR 2.1 (1-4.5)), disease during pregnancy (OR 8.9 (1.5-52)), and bedroom sharing (OR 7.1 (1.9-27.4)).

Conventionally, besides treating colitis with antibiotics, certain medications also are prescribed to improve the symptoms and quality of life of the patients, including anti-diarrheal medications.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that process anti-colitis activity researchers compared the effects of broccoli-derived nanoparticle (BDN) and SFN on three mouse colitis models.

According to the data collected from the experiment, orally given nanoparticles isolated from broccoli extracts protected mice against colitis by-mediating the activation of 5'-adenylic acid-activated protein kinase (AMPK) associated with cellular energy homeostasis.

In the immune analysis, BDN prevented the dendritic cells (DCs) to act as messengers between the innate and the adaptive immune systems in dextran sulfate sodium (DSS)-induced colitis in C57BL/6 (B6) mice by targeting dendritic cells (DCs) activation and inducing DC tolerance.

Compared to BND, DCs pre-pulsed with SFN also prevented DSS-induced colitis in B6 mice,, similar to those of BND.

Taken altogether, broccoli derived nanoparticle (BDN) or SFN isolated from broccoli may be considered a functional food for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase by Deng Z1, Rong Y1, Teng Y1, Mu J1, Zhuang X1, Tseng M2, Samykutty A1, Zhang L1, Yan J1, Miller D1, Suttles J1, Zhang HG. (PubMed)
(2) Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study by Baron S1, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, Yzet T, Lerebours E, Dupas JL, Debeugny S, Salomez JL, Cortot A, Colombel JF. (PubMed)