Green Pea (Pisum Sativum) Eradicates Ehrlich Ascites Carcinoma Cells

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of organs or glands. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Ehrlich-Lettre ascites carcinoma (EAC) known as Ehrlich cell is a type of abnormal buildup of fluid in the abdomen tumor cultured in mice.


Ehrlich Ascites Carcinoma cells induced subcutaneous tumors in 129/SvJ mice has been studied a number of researchers such as Sneha Mishra, Ankit Kumar Tamta for its effect on several types of cancer.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved in the onset of cancer.


Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) effects on Ehrlich ascites carcinoma cell line.

Based on the results, a lectin isolated from green pea at the concentration range of 8-120 μg/ml in RPMI 1640 medium showed an 11.7-84% inhibitory effect against Ehrlich ascites carcinoma (EAC) cells.

Furthermore, in vivo, administered 2.8 mg/kg/day and 1.4 mg/kg/day (i.p.) respectively for five consequent days exerted a strong 63% and 44% growth inhibition against EAC cells in a mice model.


More importantly, pea lectin injection into the EAC bearing mice for 10 days significantly increased the hemoglobin and RBC with the decrease of WBC levels toward the normal and induced the cell cycle arrest at the G2/M phase of EAC cells, according to flow cytometry assay.


Pea lectin also induced cancer cell apoptosis by increasing the levels of pro-apoptotic protein and decreasing the anti-apoptosis in the tested cells, after 5 consecutive days of treatment.

Taken altogether, green peas with abundant phytochemical lectin may be considered a functional food for the prevention and treatment of cancers, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo in mice by Kabir SR1, Nabi MM, Haque A, Rokon Uz Zaman, Mahmud ZH, Reza MA. (PubMed)