Broccoli's Sulforaphane (SF) Protects the Kidney Cell Against Chemo Drug Adverse Effects

Kidneys are 2 bean-shaped organs found in the left and right side in the retroperitoneal space in the body.

The function of kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.

Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.

Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.

Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.

Chemotherapy is a drug treatment that kills cancer cells by inducing cytotoxicity. Most cases of chemotherapy have been found to causes severe side effects on the patient, including fatigue, loss of appetite, nausea, bowel issues such as constipation or diarrhea, hair loss, mouth sores, skin and nail problems.

Chemo drugs have also been shown to induce nephrotoxicity, by increasing the production of ROS and inhibiting several antioxidant enzymes to orchestrating kidney oxidative stress injury.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anti kidney toxicity induced by chemo-drugs, researchers examined the effects sulforaphane (SF), a natural constituent of cruciferous vegetables such as broccoli, on Cisplatin (cis-diamminedichloroplatinum II, CIS) nephropathy.

In rodents, before treatment with FN, cisplatin therapy triggered marked activation of stress signaling pathways to promote cancer cell death in the kidney by increasing the DNA fragmentation, apoptotic proteins,

Furthermore, CIS also exhibited the terminal associated with attenuation of various prosurvival signaling pathways and increased the levels of the pro-inflammatory cytokines in the kidney.


In other words, the injection of CIS not only induced kidney injury but also caused damage to the death of the kidney cells, through several aforementioned mechanisms.


After the administration of SF, all these effects were significantly attenuated by pretreatment of rodents with SFN.

Based on the evidence, researchers wrote, " SFN is able to prevent the CIS-induced renal injury by modulating these pathways, providing a novel approach for preventing this devastating complication of chemotherapy".

Taken altogether, the consequences of these results suggest that the broccoli process the potential anti-side effect of CIS in the induction of kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy by Guerrero-Beltrán CE1, Mukhopadhyay P, Horváth B, Rajesh M, Tapia E, García-Torres I, Pedraza-Chaverri J, Pacher P. (PubMed)