Herbal Coltsfoot(Tussilago farfara) Protects the Small Intestinal Epithelium in Chemotherapy

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

Digestion is a process of the digestive system by breaking out down food after food intake through mechanical and enzymatic action.

The intestinal epithelium formed part of the intestinal mucosal barrier, is the single-cell layer formed the lining of both the small and large intestine(colon) of the gastrointestinal tract with functions to absorb useful substances into the body and blocks the entry of harmful pathogens.

Dr. Catalioto RM, the lead scientist in examing the intestinal epithelial barrier dysfunction wrote, "Epithelial cells are linked together at the apical junctional complex by tight junctions that reduce the extracellular space and the passage of charge entities while forming a physical barrier to lipophilic molecules".

And, "Cultured intestinal epithelial cells have been extensively used to study intestinal absorption of newly synthesized drugs and the regulation of tight junctions structure and function. In vitro mild irritants, proinflammatory cytokines, toxins and pathogens, and adverse environmental conditions open tight junctions and increase paracellular permeability, an effect often accompanied by immune activation of the enterocytes".

In other words, intestinal epithelium dysfunction induces the risk of various intestinal and non-intestinal disorders including inflammatory bowel disease, celiac disease, and diarrhoeal infection.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the improvement of the digestive functioning, researchers examined the protective effect of Tussilagone (TSL) on mall intestinal epithelium against foreign pathogens.

According to the DNA comet assay, in C57Bl/6 mice, the chemical constituent of polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis in the intestinal epithelial cells.

In other words, TSL not only enhanced the efficacy of the chemo drug but also inhibited the cytotoxicity of the adverse effect of chemo-induced death or DNA damage of intestinal epithelial cells through its geno-protective properties.

Taken altogether, coltsfoot may be considered a remedy for the protection of small intestinal functioning against damage, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay by Safonova EA1, Lopatina KA2, Vychuzhanina AV2, Mashanova VA2, Razina TG2, Borovskaya TG2, Zueva EP2, Gur'ev AM3, Belousov MV. (PubMed)