Cruciferous vegetables, the Antagonistic Foods Against Cancer

Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.

Most cancer starts at the cell on the surface of the inner lining of the organ's tissue. At the later stage, cancer cells can be found in the deeper layers of the infected organ.

In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.

The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why healthy cells' DNA is alternated.

Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.

According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increase in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.

Glucosinolates are sulfur-containing compounds found in cruciferous vegetables, including broccoli, Brussels sprouts, and kale.

Drug Antagonism is an interaction between two or more drugs that have opposite effects on the body, by blocking or reducing the effectiveness of one or more of the drugs.

Antagonistic food's effects on cancer are to interfere with the metabolism of cancer by interacting with the activation of transcription factors, enzymes, and proteins associated with the anti-cancer activity.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods that process anti-cancer property, researchers investigated the antagonistic activity of benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane (SFN) found across the cruciferous vegetables.

Based on the results of differentiation, all three BITC, PEITC, and SFN showed strong effects against cancer by direct/indirect interaction with Nrf2, a protein associated with the expression of antioxidants and NF-κB protein involved in the production of inflammatory cytokines.

In the comparison assay, BITC showed the affinity to inhibit the NF-κB due to the presence of additional benzyl structure compared to SFN.

Collectively, researchers said, " We have also discussed the molecular interaction(s) of the antagonistic effect of BITC, PEITC, and SFN with Nrf2 and NF-κB to prevent cancer and promote cancer cell apoptosis.


Taken altogether, dietary cruciferous vegetables processed a high amount of benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane (SFN) may be considered antagonistic foods against cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers by Soundararajan P1, Kim JS. (PubMed)