Healthy Food Broccoli's Sulforaphane (SFN) Inhibits Urologic Cancer Cells in Vitro

Urologic cancers are a class of medical conditions including
*Prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to the distant parts of the body.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

* Kidney cancer is a medical condition characterized by irregular cell growth in the tissue of kidneys.

At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.

* Bladder cancer
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

* Cancer of the renal pelvis and ureter is a cancer of renal pelvis on the top part of the ureter and the ureter which is a long tube that connects the kidney to the bladder

* Testicle cancer

Testicular Cancer is cancer that arises in the testicles (testes), located inside the scrotum. testicles form part of the male reproductive system, responding to the production and reproduction of male sex hormones and sperm.

* Cancer of the penis
Penis cancer is a type of irregular cell growth formed in the tissues of the penis.

* Urethra cancer
Urethral cancer is a type of medical condition caused by the growth of malignant cells in tissues of the urethra, the tube that carries urine from the bladder and out of the body.

The most common symptoms of urologic cancers are the difficulty starting to urinate or difficulty holding urine back, weak urine stream or interruption of stream, painful urination, pelvic discomfort, bone pain, erectile dysfunction (ED), painful ejaculation, blood in the urine and blood in the semen.

The joint study led by the National Cancer Center, Goyang, Korea, wrote, "During 1999-2012 (In Korean), urological cancer occurred in 155,991 patients (Table 1). The most common cancer was prostate cancer (66,812 patients) followed by bladder cancer (41,549 patients), kidney cancer (36,836 patients), renal pelvis and ureter cancer (7,537 patients), testis cancer (2,439 patients), and penile cancer (818 patients)".

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects sulforaphane (SF), a natural compound sulforaphane (SFN) anti-urologic cancer effects.

According to the tested analysis, the application of SFN shows a remarkable anti-tumor effect in vitro and in vivo without exerting toxicity.


Furthermore, based on available evidence from epidemiological, in vitro, preclinical and early phase trials, SFN was not only available in standardized formulations, bioavailable- both systemically and in the bladder but also exerted a significant anti bladder cancer through multiple mechanisms.

Additionally, similar to its effects on urological cancer, SFN induced cancer apoptosis without causing cytotoxicity.

Collectively, researchers said, "sulforaphane (SFN) represents a promising potential chemopreventative agent in bladder cancer".

Taken altogether, Broccoli processed abundant bioactive compound SFN, which may be considered a functional food for the prevention and treatment of urologic tumors, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors by Juengel E1, Erb HHH2, Haferkamp A2, Rutz J3, Chun FK3, Blaheta RA. (PubMed)
(2) Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea by Jae Young Joung, MD, Ph.D.,1 Jiwon Lim, MS,2 Chang-Mo Oh, MD, Ph.D.,2 Kyu-Won Jung, MS,2 Hyunsoon Cho, Ph.D.,2 Sung Han Kim, MD, Ph.D.,1 Ho Kyung Seo, MD, Ph.D.,1Weon Seo Park, MD, Ph.D.,1 Jinsoo Chung, MD, Ph.D.,1 Kang Hyun Lee, MD, Ph.D.,1 andYoung-Joo Won, Ph.D. (PMC)
(3) Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach by Andrew Leone,1 Gregory Diorio,1 Wade Sexton,1 Michael Schell,2 Mark Alexandrow,3Jed W. Fahey,4 and Nagi B. Kumar. (PubMed)