The Curable Smoothies: April 2016

Saturday, April 30, 2016

All About #CurableVitamins: The effect of Vitamin E on Alzheimer's disease

The Effect of Vitamin E on Alzheimer's disease

Alzheimer's disease is a brain disorder correlated with major reduction of neurons to the respective target areas through destruction of brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

1. The serum of vitamin E
Epidemiological studies, in determination of the forms of vitamin E in reduced risk of Alzheimers disease have been inclusive. According to the joint study by the University and University of Perugia, elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults(1). In other study of vitamin E and risk if AD in advanced age, high plasma levels of beta-tocopherol was associated to reduced risk of developing AD but levels of alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model(2). The differentiation of vitamin E marker in mild cognitive impairment (MCI) from cognitively intact control (CTL) subjects, suggested nutritional biomarkers detected in plasma-tocopherols and tocotrienols-as indirect indicators of the onset of AD(3). Other researchers suggest that various tocopherol forms rather than alpha- tocopherol alone may be important in the vitamin E protective association with Alzheimer disease(4) andlow plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD(5)(6).

2. The conflict results
A Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to moderate AD, combination of 2000 IU/d of alpha tocopherol and memantine, exhibited the slower functional decline in mild to moderate AD(7). A placebo-controlled, clinical trial of vitamin E in patients with moderately advanced Alzheimer disease treatment with with 2000 IU (1342 alpha-tocopherol equivalents) vitamin E/d. may slow functional deterioration and prevent a clinical diagnosis of Alzheimer disease in elderly persons with mild cognitive impairment(8). In the testing of the hypothesis of oxygen free radicals are probably involved in the deterioration of cognitive function, showed a positive effect of alpha-tocopherol in reduced risk of the cognitive impairment but inconsistent for women taking vitamin E alone, with no evidence of higher scores with longer durations of use(9). The double-blind, randomized trials in which treatment with vitamin E at any dose was compared with placebo for patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) showed a positive effects of vitamin E in treatment of AD or MCI, but future trials assessing vitamin E treatment in AD should not be restricted to alpha-tocopherol(10). Unfortunately, there is no evidence of vitamin E in the prevention or treatment of people with AD or MCI, according to the study by the Milton Court Resourse Centre(11) and The Maudsley Hospital(12).

Taking altogether, without going into reviews, serum of vitamin E and vitamin E may be used as an indicator for the early onset and in reduced risk and treatment of Alzheimers' disease respectivelt. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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References
(1) Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults by Mangialasche F1, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M.(PubMed)
(2) High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age by Mangialasche F1, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, Fratiglioni L.(PubMed)
(3) Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol by Mangialasche F1, Westman E, Kivipelto M, Muehlboeck JS, Cecchetti R, Baglioni M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kłoszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund LO, Simmons A, Mecocci P; AddNeuroMed consortium.(PubMed)
(4) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change by Morris MC1, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA(PubMed)

(5) Tocopherols and tocotrienols plasma levels are associated with cognitive impairment by Mangialasche F1, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium.(PubMed)
(6) Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults by Mangialasche F1, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M.(PubMed)

(7) Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial by Dysken MW1, Sano M2, Asthana S3, Vertrees JE4, Pallaki M5, Llorente M6, Love S1, Schellenberg GD7, McCarten JR1, Malphurs J8, Prieto S8, Chen P5, Loreck DJ9, Trapp G10, Bakshi RS10, Mintzer JE11, Heidebrink JL12, Vidal-Cardona A13, Arroyo LM13, Cruz AR14, Zachariah S14, Kowall NW15, Chopra MP15, Craft S16, Thielke S16, Turvey CL17, Woodman C17, Monnell KA18, Gordon K18, Tomaska J1, Segal Y1, Peduzzi PN19, Guarino PD.(PubMed)
(8) Vitamin E and Alzheimer disease: the basis for additional clinical trials by Grundman M.(PubMed)
(9) High-dose antioxidant supplements and cognitive function in community-dwelling elderly women by Grodstein F1, Chen J, Willett WC.(PubMed)
(10) Vitamin E for Alzheimer's dementia and mild cognitive impairment by Farina N1, Isaac MG, Clark AR, Rusted J, Tabet N.(PubMed|)
(11) Vitamin E for Alzheimer's disease and mild cognitive impairment by Isaac MG1, Quinn R, Tabet N.(PubMed)
(12) Vitamin E for Alzheimer's disease by Tabet N1, Birks J, Grimley Evans J.(PubMed)

The #Curablesmoothie of Green tea, Tomato and Brazil Nut for Prevention and treatment of Nonpuerperal mastitis

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for treatment of Nonpuerperal mastitis has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not
produced same potentials in large sample size and mutli centers human trials.

Non-puerperal mastitis, also known as non-lactating mastitis, includes(encompasses) all the causes of inflammatory changes in the female breast and mammilla(breast nipple) not related to lactation(pregnancy and breasting feeding). According to the guideline led by the Service de chirurgie gynécologique, hôpital Tenon, Non-puerperal mastitis depending to the underlying of the types and size of the infectious and inflammatory mastitis(8). Non-puerperal mastitis may be a masking pre-existing breast malignancy, resulted from chemical inflammation in the breast tissue, superimposed by a secondary bacterial infectionor or caused by sports activities or a seat belt injury(9).

The Incredible and Effective smoothie for Prevention and treatment of Nonpuerperal mastitis
Yield: 2 servings (about 8 ounces each)
1 cup tomato
1/2 cup Brazil nut
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies from well known institutions suggested that Green tea, Tomato and Brazil Nut

may process naturally potential ingredients, for reduced risk and treatment for mastitis.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its phytochemical EGCG normalized LPS-induced low activities of antioxidant enzymes as well as decreased the high levels of inflammatory cytokine into the duct of mammary gland(8).

According to the Agriculture and Agri-Food Canada, EGCG also expressed anti microbial effect against antibiotics-resistant strains of S. aureus in control of bovine mastitis and food poisoning caused by S. aureus12).

Vitamin A(Tomato or carrot), is a fat soluble vitamin was found to associate with low concentrations in cow with severity of mastitis(3). According to the University of Guelph, a 100 ng/mL increase in serum retinol was associated with a 60% decrease in the risk of early lactation clinical mastitis(4).
Dr. Erskine RJ said, " vitamins A (or beta-carotene) and E status should be monitored in herds" to prevent risk for mastitis and reproductive disorders(5).

Selenium one of most powerful antioxidant mineral found abundantly in Brazil nut may be used for prevention and treatment of mastitis and improved milk quality in dairy herds, according to the Ohio State University(6).

Dr. Hogan JS and colleagues at the Ohio State University suggested the important role of selenium in exhibition of immune modulated effect against mastitis, in animal model(7).

The effectiveness of Green Tea, Tomato and Brazil Nut may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Mastitis with little or no adverse effects.

Women who are at increased risk of Mastitis may drink at least one serving daily and women with Mastitis may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) Bioassay-guided purification and identification of antimicrobial components in Chinese green tea extract by Si W1, Gong J, Tsao R, Kalab M, Yang R, Yin Y.(PubMed)
(3) Relationship between vitamin A and beta-carotene in blood plasma and milk and mastitis in Holsteins by Chew BP, Hollen LL, Hillers JK, Herlugson ML.(PubMed)
(4) Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease by LeBlanc SJ1, Herdt TH, Seymour WM, Duffield TF, Leslie KE.(PubMed)
(5) Nutrition and mastitis by Erskine RJ1.(PubMed)
(6) Dietary vitamin E and selenium affect mastitis and milk quality by Smith KL1, Hogan JS, Weiss WP.(PubMed)
(7) Role of vitamin E and selenium in host defense against mastitis by Hogan JS1, Weiss WP, Smith KL.(PubMed)
(8) [Inflammatory and infectious breast mastitis outside of pregnancy and lactation: Guidelines].[Article in French]by Laas E1, Touboul C2, Kerdraon O3, Catteau-Jonard S4.(PubMed)
(9) Non-puerperal mastitis masking pre-existing breast malignancy: importance of follow-up imaging by Jin Kyung An1 , Jeong Joo Woo1 , Seung A Lee2(CrossMark)

Friday, April 29, 2016

All About #CurableVitamins: The effect of Vitamin E on Endometrial Cancer

The Effect of Vitamin E on Endometrial Cancer

The incidence of endometrial cancer among white women are higher in comparison of black women. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Depending to the stage and grade of the cancer, chemotherapy such as Doxorubicin, Cisplatin. Paclitaxel, Carboplatin, Topotecan may be necessary after surgery. Although epidemiological studies focusing the effective of vegetables and fruits in reduced risk and treatment of endometrial cancer with inconclusive results(1)(2)(3)(4), certain Vitamins, through clinical studies have found to be effective in reduced risk and treatment of endometrial cancer with little or no side effect.

Antioxidants in epidemiological evidences, are associated to reduced risk of endometrial cancer caused by DNA damage have been controversial. In dose-response meta-analyse, study suggested that dietary intakes of beta-carotene, vitamin C, and vitamin E from food sources, consisted an inverse relationship ofendometrial cancer risk(5)(6). The study association between intakes of selected food groups and nutrients with EC risk among 541 women with histologically confirmed EC and 541 women with an intact uterus and noncancer diagnoses seen at Roswell Park Cancer Institute between 1982 and 1998, indicated that intake of vegetable dietary vitamin E are associated with decreased risk of EC(7)(8)(9). But in the study of Instituto de Biotecnología y de Biomedicina with endometrial cells incubated at several hydrogen peroxide concentrations, alpha-tocopherol included in liposomes (1.6 microg) found no antioxidant effect detected in cells in culture(7)

Taking altogether, vitamin E may be effective in reduced risk and treatment of endometrial cancer, but large example size and muticenter studies are necessary to validate its effectiveness. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence BY Kim MK, Park JH(PubMed)
(2) Epidemiological studies on brassica vegetables and cancer risk by Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA(PubMed)
(3) Brassica vegetables and cancer prevention. Epidemiology and mechanisms by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(PubMed)
(4) Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis by Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML(PubMed)
(5) Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis by Bandera EV1, Gifkins DM, Moore DF, McCullough ML, Kushi LH(PubMed)
(6) Higher intakes of vegetables and vegetable-related nutrients are associated with lower endometrial cancer risks. by Yeh M1, Moysich KB, Jayaprakash V, Rodabaugh KJ, Graham S, Brasure JR, McCann SE(PubMed)
(7) Higher intakes of vegetables and vegetable-related nutrients are associated with lower endometrial cancer risks by Yeh M1, Moysich KB, Jayaprakash V, Rodabaugh KJ, Graham S, Brasure JR, McCann SE(PubMed)
(8) Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China by Xu WH1, Dai Q, Xiang YB, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)
(9) Intake of selected micronutrients and the risk of endometrial carcinoma by Negri E1, La Vecchia C, Franceschi S, Levi F, Parazzini F.(PubMed)
(10) Antioxidant activity of N-acetylcysteine, flavonoids and alpha-tocopherol onendometrial cells in culture by Estany S1, Palacio JR, Barnadas R, Sabes M, Iborra A, Martínez P(PubMed)

The #Curablesmoothie of Green Tea, Grape and Ginger for Reduced Risk and Treatment of Nephritis

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Nephritis

Yield: 2 servings (about 8 ounces each)
3/4 cup pomegranate
3/4 cup of cherries
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the pomegranate, cherries, and green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Nephritis is a condition of inflammation of kidneys

Many suggestions that pumpkin seeds used in conjunction with green tea may be a potential combination for reduced risk and treatment of Nephritis. due to the phytochemicals of catechins in green tea(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicien for treatment of variety of diseases, including cancers and heart diseases.

According to the Graduate Institute of Medical Sciences, National Defense Medical Center, phytochemical Epigallocatechin-3-gallate isolated from green tea inhibited nephritis through it relation of proinflammatory cytokines and enhanced antioxidant signaling pathway(1).

The major chemical constituent EGCG also prevented cisplatin-induced nephrotoxicity and reduced due to over expression of NF-kappaB, the inflammatory pathway(2).

The Shanghai Tenth People's Hospital of Tongji University study in the evaluation of the effects of EGCG in animal with glomerulonephritis said, " EGCG pretreatment period. Importantly, mortality and renal dysfunction were significantly attenuated even when the polyphenol treatment was initiated 1 week after the onset of GN. Thus, EGCG reversed the progression of immune-mediated GN in mice by targeting redox and inflammatory pathways"(3).

Resveratrol, found abundantly in grape, blueberry and peanut is a phytochemical in the class of Stilbenoids, exhibited anti inflammatory diseases, including the Nephritis, through attenuated on

proteinuria, hypoalbuminemia and hyperlipidemia(4). According to University of Yamanashi, the phytochemicals also expressed inhibition of pro inflammatory cytokines in the NF-kappaB pathway via antioxidant and oxidative stress effects(5).

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil. It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc. According to the Dr. Nassan M and Dr. Mohamed EH ginger expressed strongly antimicrobial and immuno modulating effects on certain pathogenic microorganisms in ameliorated acute hematogenous pyelonephritis in animal model(6).

The effectiveness of Green Tea, Grape and Ginger may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for Reduced Risk of Nephritis with little or no adverse effects.

People who are at increased risk of Nephritis due to family history, weaken immunity.... should drink 1 serving daily and people with Nephritis should drink as much as they can, depending to digestive toleration.
Life style and diet pattern changed are recommended

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(1) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)

(2) Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats by Sahin K1, Tuzcu M, Gencoglu H, Dogukan A, Timurkan M, Sahin N, Aslan A, Kucuk O.(PubMed)

(3) The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis by Peng A1, Ye T, Rakheja D, Tu Y, Wang T, Du Y, Zhou JK, Vaziri ND, Hu Z, Mohan C, Zhou XJ.(PubMed)
(4) Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats by Nihei T1, Miura Y, Yagasaki K.(PubMed)
(5) Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells by Uchida Y1, Yamazaki H, Watanabe S, Hayakawa K, Meng Y, Hiramatsu N, Kasai A, Yamauchi K, Yao J, Kitamura M.(PubMed)
(6) Immunopathological and antimicrobial effect of black pepper, ginger and thyme extracts on experimental model of acute hematogenous pyelonephritis in albino rats by Nassan MA1, Mohamed EH2.(PubMed)

Thursday, April 28, 2016

All About #CurableVitamins: The effect of Vitamin E on Prostate Cancer

The Effect of Vitamin E on Prostate Cancer

The widespread of prostate cancer, once considered a disease of aging male, now has become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population. Epidemiological studies, linking vitamin E in reduced risk of prostate cancer have produced conflict results. It may be due to age related, smoking habit, gene mutation, types of tocopherol, etc.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth with possibility of spreading to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The conflict results
The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed an adverse effect of dietary supplement with vitamin E significantly increased the risk of prostate cancer among healthy men through illustration per 1000 person-years.(1)or prevented the development of prostate cancer in the population of relatively healthy men(2). In the study of combination used of vitamin C and E of total of 14,641 male physicians in the United States initially aged 50 years or older, including 1307 men with a history of prior cancer at randomization, also suggested that neither vitamin E nor C supplementation reduced the risk of prostate or totalcancer(3). Positively, on prostate cancer (PCa), in N-methyl-N-nitrosourea (MNU)-induced epithelial dysplasia in the rat ventral prostate (VP), animals fed a control+γ-tocopherol (CT+γT) significantly attenuated the adverse effects of MNU in the VP through the deceased epithelial dysplasia, along with the cell proliferation index, GST-pi and Cox-2 immunoexpression(3). Some researchers insisted that different forms of vitamin E exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease(5).

The serum of tocopherol
In the study of the effects of Serum α-tocopherol and γ-tocopherol in prostate cancer patient showed that higher serum α-tocopherol was associated with significantly lower prostate cancer risk and by contrast, risk was non-significantly elevated among men with higher γ-tocopherol concentrations(12).
Some researchers suggested that higher prediagnostic serum concentrations of alpha-tocopherol, but not dietary vitamin E, was associated with lower risk of developing prostate cancer, particularly advanced prostate cancer(13). But in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, showed that risk of prostate cancer reduced with high serum tocopherols and higher circulating concentrations of the major vitamin E fractions, alpha-tocopherol and gamma-tocopherol(14) and higher alpha-tocopherol (and not beta-carotene or retinol) status increases overall prostate cancer survival(15).

The benefits
Study of 8-wk-old male TRAMP mice fed 0.1% γ-TmT or a control diet for 16 weeks, observation of nuclear factor-erythroid 2-related factor 2 (Nrf2), showed that γ-tocopherol-rich mixture of tocopherols (γ-TmT) inhibited CpG methylation (promoters of genes can lead to their silencing, a feature found in a number of human cancers ) in the Nrf2 promoter in the prostate of transgenic adenocarcinoma of the mouse prostate (TRAMP) and in TRAMP-C1 cells(6). Inprostate cancer, combination use of NAG-1 and Vitamin E succinate (VES), showed the enhancement of VES in >3-fold increase in the half-life of NAG-1 mRNA through transcriptional/post-transcriptional mechanism in a p38 kinase-dependent manner(7). On prostate cancer in male smokers. long-term supplementation with alpha-tocopherol substantially reduced prostate cancerincidence and mortality(8). In the study of the incidence of prostate cancer risk associations of alpha-tocopherol, gamma-tocopherol, and selenium, indicated that risk of prostate cancer declined, but not linearly, with increasing concentrations of alpha-tocopherol; gamma-tocopherol, men in the highest fifth of the distribution had a fivefold reduction in the risk of developing prostate cancer than men in the lowest fifth(9).
Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of 29,133 Finnish male smokers aged 50-69 years, showed a decreased risk of prostate cancer with oral administration of daily α-tocopherol (50 mg) for a median of 6.1 years and lowerprostate cancer mortality(10). Other suggestion of inhibitory prostate cancer activities of δ-T and γ-T (than α-T) may be as a result of due trapping of reactive nitrogen species and their capacity to generate side-chain degradation products(11).

Taking altogether, most researchers agreed that intake of alpha-tocopherol may be beneficiary in reduced risk and treatment of prostate cancer accompanied with diet, life style change(16)(17)(18). Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E CancerPrevention Trial (SELECT) by Klein EA, Thompson IM Jr, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, Karp DD, Lieber MM, Walther PJ, Klotz L, Parsons JK, Chin JL, Darke AK, Lippman SM, Goodman GE, Meyskens FL Jr, Baker LH(PubMed)
(2) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) byLippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL Jr, Baker LH, Coltman CA Jr.(PubMed)
(3) Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial by Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE(PubMed)
(4) Protective effect of γ-tocopherol-enriched diet on N-methyl-N-nitrosourea-induced epithelial dysplasia in rat ventral prostate by Sanches LD, Santos SA, Carvalho JR, Jeronimo GD, Favaro WJ, Reis MD, Felisbino SL, Justulin LA Jr(PubMed)
(5) Dietary antioxidants and prostate cancer: a review by Vance TM, Su J, Fontham ET, Koo SI, Chun OK.(PubMed)
(6) A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostatetumors of TRAMP mice via epigenetic inhibition of CpG methylation by Huang Y, Khor TO, Shu L, Saw CL, Wu TY, Suh N, Yang CS, Kong AN(PubMed)
(7) Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism by Shim M, Eling TE (PubMed)
(8) long-term supplementation with alpha-tocopherol substantially reduced prostate cancer incidence and mortality by Heinonen OP1, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Mäenpää H, Teerenhovi L, Koss L, Virolainen M, Edwards BK.(PubMed)
(9) Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer by Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP, Morris JS, Comstock GW(PubMed)
(10) Effects of α-tocopherol and β-carotene supplementation on cancer incidence and mortality: 18-Year postintervention follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study by Virtamo J, Taylor PR, Kontto J, Männistö S, Utriainen M, Weinstein SJ, Huttunen J, Albanes D.(PubMed)
(11) Cancer prevention by different forms of tocopherols by Yang CS, Suh N(PubMed)
(12) Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO Screening Trial: a nested case-control study by Weinstein SJ, Peters U, Ahn J, Friesen MD, Riboli E, Hayes RB, Albanes D(PubMed)
(13) Serum and dietary vitamin E in relation to prostate cancer risk by Weinstein SJ, Wright ME, Lawson KA, Snyder K, Männistö S, Taylor PR, Virtamo J, Albanes D.(PubMed)
(14) Serum alpha-tocopherol and gamma-tocopherol in relation to prostate cancerrisk in a prospective study by Weinstein SJ, Wright ME, Pietinen P, King I, Tan C, Taylor PR, Virtamo J, Albanes D(PubMed)
(15) Associations between alpha-tocopherol, beta-carotene, and retinol andprostate cancer survival by Watters JL, Gail MH, Weinstein SJ, Virtamo J, Albanes D(PubMed)
(16) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL.(PubMed)
(17) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(18) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

The #Curablesmoothie of celery, apple and green tea for Hypertensive complication caused by Nutcracker syndrome

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Nutcracker syndrome is a vascular compression of the left renal vein between the superior mesenteric artery (SMA) and aorta, causing increased blood pressure inducing rupture of thin-walled veins to cause accumulation of haematuria. Surgical treatment may be the best option for patients with the syndrome(14)(15).

To reduce the complication of hypertension in induction of accumulation of haematuria, the following smoothie can be helpful.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. high blood pressure means raising pressure in your heart. If your blood pressure stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but also induced many irreversible adverse effects, including kidney damage.

The smoothie for people with Hypertensive complication caused by Nutcracker syndrome
Yield: 2 servings (about 8 ounces each)
3/4 cup celery
3/4 cup of apple with peel
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the celery, apple with peels, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Diet rich in fruits and vegetable and reduced intake of red meat, saturated fat and trans fat has shown to attenuated risk of hypertension(1). Recent study showed that celery(2) intake used conjunction with berries(3) and green tea(4) may be the potential drink for prevention and treatment of hypertension.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable. According to Chronic administration of hexanic, methanolic, and aqueous-ethanolic extracts of celery seed effectively exhibited an antihypertensive activity in chronic treatment of elevated BP in tested animals(5).

Dr. Dianat M and the research team at the Ahvaz Jundishapur University of Medical Sciences said," hydro-alcoholic celery leaf extract on systolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose"(6)

3‑n‑butylphthalide (NBP), an phytochemical found in celery seed used in traditional Chinese medicine exhibited significantly antihypertensive and attenuated progression of hypertensive effects through decreased oxidative stress and the expression of pro‑inflammatory cytokines(7).
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae. It is one of the most widely cultivated tree fruits. With phytochemical flavonoids, apple and its peel inhibited angiotensin converting enzyme (ACE) in promoted the development of high blood pressure, Dr Balasuriya N and Dr. Rupasinghe HP. Suggested(8)According to the Mount Sinai School of Medicine, "Flavonoid (found abundantly in fruits and vegetable)(10) intake has been inversely associated with mortality from coronary heart disease and stroke,..... Lowering blood pressure through increased dietary consumption of dietary antioxidants(such as flavonoid) may decrease the rate of end-organ damage that is secondary to hypertension"(9).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-O-gallate (EGCG), the main polyphenol presence in green tea is best known for its antioxidant and anti inflammatory effect. In animal model, the phytochemical exhibited anti hypertensive and progressive activity through reduction of oxidative stress in paraventricular nucleus of hypothalamus (PVN), the Xi'an Jiaotong University Health Science Center study showed(11).

Dr. Yarmolinsky J and the research team at the Federal University of Rio Grande do Sul, suggested that, intake of tea are shown to reduce blood pressure in individuals within prehypertensive and hypertensive ranges in the review of all relevant studies published from 1946 to September 27, 2013.(12).

Furthermore, green tea extract (GTE) inhibited the oxidative stress and ingiotensin (Ang) II induces endothelial dysfunction (ED) causes of hypertension through scavenging of superoxide anion generation, the University of Padova, insisted(13).

People who are at increased risk of hypertension caused by Nutcracker syndrome should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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References

(1) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(2) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(3) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors by Toh JY1, Tan VM, Lim PC, Lim ST, Chong MF.(PubMed)
(4) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
(5) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(6) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(7) Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats by Zhu J1, Zhang Y1, Yang C1.(PubMed)
(8) Antihypertensive properties of flavonoid-rich apple peel extract by Balasuriya N1, Rupasinghe HP.(PubMed)
(9) Dietary flavonoids and hypertension: is there a link? by Moline J1, Bukharovich IF, Wolff MS, Phillips R.(PubMed)
(10) Antihypertensive effects of the flavonoid quercetin by Perez-Vizcaino F1, Duarte J, Jimenez R, Santos-Buelga C, Osuna A.(PubMed)
(11) Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension by Yi QY1, Qi J, Yu XJ, Li HB, Zhang Y, Su Q, Shi T, Zhang DM, Guo J, Feng ZP, Wang ML, Zhu GQ, Liu JJ, Shi XL, Kang YM.(PubMed)
(12) Effect of tea on blood pressure for secondary prevention of cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials by Yarmolinsky J1, Gon G2, Edwards P2.(PubMed)
(13) Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts by Antonello M1, Montemurro D, Bolognesi M, Di Pascoli M, Piva A, Grego F, Sticchi D, Giuliani L, Garbisa S, Rossi GP.(PubMed)

(14) Surgical treatment of posterior nutcracker syndrome presented with hyperaldosteronism by Deser SB1, Onem K2, Demirag MK3, Buyukalpelli R2.(PubMed)

(15) Laparoscopic Extravascular Stent Placement for Nutcracker Syndrome: A Report of 13 Cases by Wang SZ1, Zhang WX1, Meng QJ1, Zhang XP1, Wei JX1, Qiao BP1.(PubMed)

All About #CurableVitamins: The effect of Vitamin E on Breast Cancer

The Effect of Vitamin E on Breast Cancer

Epidemiological studies, linking vitamin E in reduced risk of breast cancer focusedon variant α-tocopherol with inconsistent results. In recent study, research in γ-tocopherol, δ-tocopherol, have shown a promising potential as the vaiants exerted a greater ability in reducing inflammation, cell proliferation, and inhibiting the development of mammary hyperplasia and tumorigenesis(1)(1a)(1b)

A cohort study from the Breast Cancer Serum Bank in Columbia, free of cancer sample blood donated to the bank did not found any evidence for protective effects of alpha-tocopherol in breast cancer(3). Observation of her-2/neu indicated the correlation with Her2/neu receptor and reduced TAP expression found in breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples, α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the efficacy of doxorubicin resulting in a reduction in cell viability inbreast cancers(3a). In MCF-7 breast cancer cell line, dl-alpha-tocopherol showedevidence of a general inhibition of cell proliferation(3b). In HER-2/neu breast cancercells and in comparison of the anticancer effect of alpha-, gamma-, and delta-tocotrienols with alpha-tocopheryl succinate (alpha-TOS), the non-alpha form of T3 is more potent in inhibition of cancer activity than the synthetic VE-derivativealpha-TOS, possibly through the mitochondrial pathway, and the expression of senescent-like growth arrest markers(which provides a possible marker for the process) as p53tumor antigen), p21(regulator of cell cycle progression at G1 and S phase), , and p16(multiple tumor suppressor 1)(3c). Delta-tocotrienol, isolated from the tocotrienol-rich fraction of palm oil, showed a positive effective against metastatic breast cancers(3d). Other in the study of estrogen-responsive MCF7 cells and the estrogen-nonresponsive MDA-MB-435 cells, RRR-alpha-, beta-, gamma-and delta-tocotrienols and and RRR-delta-tocopherol induced MDA-MB-435 cells to undergo apoptosis, with the exception of RRR-delta-tocopherol, the tocopherols (alpha, beta, and gamma) and the acetate derivative of RRR-alpha-tocopherol (RRR-alpha-tocopheryl acetate)(3e).

In aggressive triple negative MDA-MB-231 cells and oestrogen-dependent MCF-7 cells, tocotrienol-rich fraction (TRF) and a tocotrienol-enriched fraction (TEF) isolated from palm oil showed a positive effect in induction of anti-proliferation and apoptosis through DNA repair protein and NF-κB, an apoptotic cell death signalling pathway(4). In HER-2/neu-overexpressing human SKBR3 and murine TUBO breast cancer cells, vitamin E form δ-tocotrienol (δ-T3) possessed significantly high cytotoxic and apoptotic activity in SKBR3 cells than other facttions of vitamin E, through mitochondrial destabilization, energy failure, and unbalanced activity of stress/survival MAPKs, namely p38 ((highly expressed in aggressive and invasive breast cancers) and ERK1/2(cell regulation) pathways(5). In human MDA-mB-231breast cancer cells, delta-tocotrienol exerted its anti cancer effect trough suppression of site-specific Rb phosphorylation and mediation of by the loss of cyclin D1(6). In estrogen-nonresponsive MDA-MB-435 and estrogen-responsive MCF-7 human breast cancer cells, vitamin E succinate (VES) or dl-alpha-tocopherol (refers to eight naturally occurring and synthetic tocopherols and tocotrienols and their acetate and succinate derivatives), induced apoptosis involving up-regulation of TGF-beta receptor II (tumor suppressor gene) expression and TGF-beta-(cell prcess), Fas- (associated with the induction of apoptosis) and JNK- (cellular apoptosis) signaling pathways(7). These results indicated that tocotrienols exerted directly inhibitory effects on the growth of breast cancer cells irrespective of estrogen receptor status, not via an estrogen receptor-mediated pathway(8).
Also in human (MCF-7 and MDA-MD-231) mammary tumor cells lines, γ-tocotrienol induced apoptosis through induction of autophagy with evidences of the presence of relatively large increase in the accumulation of monodansylcadaverine (MDC)-labeled vacuoles, a marker of autophagosome formation(9). In neoplastic(gene modification) +SA(high malignance) mammary epithelial cells, treatment with 4 microM gamma-tocotrienol, a dose that inhibited +SA cell growth by more than 50% compared with that of untreated control cells, decreased intracellular levels of activated PI3K/Akt (anti-apoptosis and increased cell proliferation) pathway(10). On mouse (+SA) and human (MCF-7, and MDA-MB-231) mammary cancer cell lines, Combined γ-tocotrienol and SU11274 (Met inhibitor) treatment resulted in synergistic inhibition through reduction in Akt (multiple cellular processes) STAT1/5 (activator of transcription 1,5 )and NFκB(a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis) activation and corresponding blockade in epithelial-to-mesenchymal transition( a process by which epithelial cells lose their cell polarity and cell-cell adhesion and start a the initiation of metastasis for cancer progression.), as indicated by increased expression of E-cadherin, β-catenin, and cytokeratins 8/18 (epithelial markers) and corresponding reduction in vimentin (mesenchymal marker) and reduction in cancer cell motility(11). In other study, treatment of gamma-tocopherol (γT) and gamma-tocotrienol (γT3) in human breast cancer cell lines, induced apoptosis via de novo ceramide synthesis(key molecules in cellular life and death decisions and the precursors to complex sphingolipids found in membranes) dependent activation of JNK/CHOP((C/EBP homologous protein)/DR5 pro-apoptotic signaling(12) and in γ-tocopherol(γT) alone, the variant showed to suppress inflammatory markers, inhibited E2 -induced cell proliferation, and up regulated PPARγ(regulation of cellular differentiation, development, and metabolism) and Nrf2 (antioxidant response pathway)expression in mammary hyperplasia(13) or modulated ER stress signaling targeting ATF3(activating transcription factor 3, involved in the complex process of cellular stress response) in breast cancer cells(14). In HER2/neu, vitamin E analog namely alpha-tocopheryloxyacetic acid, inhibited the proliferation of kills both HER2/neu positive and HER2/neu negative breast cancer cells with less toxic than existing chemotherapeutic drugs when used in combination with HER2/neu antibody(15).

Taken the evidences of the effects of tocotrienols, dietary vitamin E or vitamin E supplement may provide significant health benefits in the reduced risk and prevention and/or treatment of breast cancer when used either alone or in combination with other anticancer agents(16).

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References
(1) Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol by Smolarek AK, Suh N.(PubMed)
(1a) Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells by Sylvester PW, Shah SJ.(PubMed)
(1b) Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer bySmolarek AK, So JY, Burgess B, Kong AN, Reuhl K, Lin Y, Shih WJ, Li G, Lee MJ, Chen YK, Yang CS, Suh N.(PubMed)
(2) Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins, 2006;396-411.
(3) Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States) by Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, Stephenson HE Jr(PubMed)
(3a) Alteration of α-tocopherol-associated protein (TAP) expression in humanbreast epithelial cells during breast cancer development by Tam KW, Ho CT, Lee WJ, Tu SH, Huang CS, Chen CS, Lee CH, Wu CH, Ho YS.(PubMed)
(3b) dl-alpha-tocopherol induces apoptosis in erythroleukemia, prostate, and breast cancer cells by Sigounas G, Anagnostou A, Steiner M.(PubMed)
(3c) Gamma- and delta-tocotrienols exert a more potent anticancer effect thanalpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression by Pierpaoli E, Viola V, Pilolli F, Piroddi M, Galli F, Provinciali M.(PubMed)
(3d) Synthesis of fluorescent analogues of the anticancer natural products 4-hydroxyphenylmethylene hydantoin and delta-tocotrienol by Mudit M, Behery FA, Wali VB, Sylvester PW, El Sayed KA.(PubMed)
(3e) Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols by Yu W, Simmons-Menchaca M, Gapor A, Sanders BG, Kline K.(PubMed).
(4) Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity by Loganathan R, Selvaduray KR, Nesaretnam K, Radhakrishnan AK.(PubMed)
(5) Mitochondrial-dependent anticancer activity of δ-tocotrienol and its synthetic derivatives in HER-2/neu overexpressing breast adenocarcinoma cells by Viola V, Ciffolilli S, Legnaioli S, Piroddi M, Betti M, Mazzini F, Pierpaoli E, Provinciali M, Galli F.(PubMed)
(6) Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product by Elangovan S, Hsieh TC, Wu JM.(PubMed)
(7) Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells by Shun MC, Yu W, Gapor A, Parsons R, Atkinson J, Sanders BG, Kline K.(PubMed)
(8) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status by Nesaretnam K, Stephen R, Dils R, Darbre P.(PubMed)
(9)γ-Tocotrienol-induced autophagy in malignant mammary cancer cells by Tiwari RV, Parajuli P, Sylvester PW.(PubMed)
(10) Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity by Shah SJ, Sylvester PW.(PubMed)
(11) Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration by Ayoub NM, Akl MR, Sylvester PW.(PubMed)
(12) Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells by Gopalan A, Yu W,Jiang Q, Jang Y, Sanders BG, Kline K.(12)
(13) Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia by Smolarek AK, So JY, Thomas PE, Lee HJ, Paul S, Dombrowski A, Wang CX, Saw CL, Khor TO, Kong AN, Reuhl K, Lee MJ, Yang CS, Suh N.(PubMed)
(14) Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells by Patacsil D, Tran AT, Cho YS, Suy S, Saenz F, Malyukova I, Ressom H, Collins SP, Clarke R, Kumar D.(PubMed)
(15) The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer by Hahn T, Bradley-Dunlop DJ, Hurley LH, Von-Hoff D, Gately S, Mary DL, Lu H, Penichet ML, Besselsen DG, Cole BB, Meeuwsen T, Walker E, Akporiaye ET.(PubMed)
(16) Potential role of tocotrienols in the treatment and prevention of breast cancer by Sylvester PW, Akl MR, Malaviya A, Parajuli P, Ananthula S, Tiwari RV, Ayoub NM.(PubMed)

The #CurableSmoothie of Green tea, Grape and Sweet Potato for Prevention and Treatment of hydronephrosis caused by Kidney Stones

Treatment of Green tea in a total of 120 Wistar rats study also exhibited decreased urinary oxalate excretion and calcium oxalate deposit formation due to antioxidative effects(3).

Dr. Kanlaya R and colleagues in the study led by the Mahidol University said, " EGCG in reducing COM crystal deposition in previous animal models of kidney stone disease. Thus, EGCG may be useful for the prevention of new or recurrent stone formation"(4).

Gallotannin, class of molecules belongings to the hydrolysable tannins found abundantly in grape and blueberry may also exert protective effect against forming of kidney stone(5). According to the Kyung Hee University, gallotannin suppressed calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells by upregulating antioxidant expression(5).

Furthermore, the 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose derivative of gallotannin, attenuated r renal crystallization and oxidative renal cell injury for treatment of nephrolithiasis(6).

Vitamin E, a fat soluble vitamin found abundantly in sweet potato may also induced protective effect against kidney stone forming through it antioxidant in involvement of free radical-mediated lipid peroxidation-induced membrane damage in the pathogenesis of calcium oxalate crystal deposition and retention(7).

Dr. Thamilselvan S and Dr. Menon M. said, " excess vitamin E completely prevented calcium oxalate deposition, by preventing peroxidative injury and restoring renal tissue antioxidants and glutathione redox balance"(8).

According to the National Taiwan University Hospital, Vitamin E attenuates crystal formation in rat kidneys through educing calcium oxalate accumulation via attenuation of tubular cell death and enhancement of the defensive roles of osteopontinin (OPN), and Tamm-Horsfall protein as crystallization inhibitors(9).

The combination of Green tea, Grape and Sweet Potato smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of hydronephrosis caused by Kidney Stones without inducing adverse effects.

People who are at increased risk of hydronephrosis caused by Kidney Stones due to drinking habit, family history .....should drink at least one cup daily and people with hydronephrosis caused by Kidney Stones should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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References
(1) Can ureteral stones cause pain without causing hydronephrosis? bySong Y1, Hernandez N2, Gee MS3, Noble VE4, Eisner BH5.(PubMed)
(2) Effects of green tea on urinary stone formation: an in vivo and in vitro study by Jeong BC1, Kim BS, Kim JI, Kim HH.(PubMed)
(3) Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis by Itoh Y1, Yasui T, Okada A, Tozawa K, Hayashi Y, Kohri K.(PubMed)
(4) EGCG decreases binding of calcium oxalate monohydrate crystals onto renal tubular cells via decreased surface expression of alpha-enolase by Kanlaya R1,2, Singhto N1,2, Thongboonkerd V3,4.(PubMed)
(5) Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells by Lee HJ1, Jeong SJ, Park MN, Linnes M, Han HJ, Kim JH, Lieske JC, Kim SH.(PubMed)
(6) 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model by Lee HJ1, Jeong SJ, Lee HJ, Lee EO, Bae H, Lieske JC, Kim SH.(PubMed)
(7) Calcium oxalate stone disease: role of lipid peroxidation and antioxidants by Selvam R1.(PubMed)
(8) Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status by Thamilselvan S1, Menon M.(PubMed)

Wednesday, April 27, 2016

All About #CurableVitamins: The effect of Vitamin D on Weight Loss

The Effect of Vitamin D on Weight Loss

The prevalence of extreme overweight and obesity has caused concerns of scientific community in the South East Asian population, due unhealthy diet and life style change over 2 decades of economic prosperity. Overweight and obesity have reached epidemic proportions in many Asian countries, affecting even younger age than in Western populations with economic burden in the development of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1). One of six Malaysian are either extreme overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and according to global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of global DALYs are caused by overweight or obesity, worldwide(2).
Epidemiological studies, linking herbal medicine, foods and vitamins in preventing and treating these diseases have been inconclusive(a)
Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression. According to the Georgetown University Medical Center, average daily food intake was decreased only with the herbal formulation, not the phenylpropanolamine (PPA) at the low and high doses, in comparison of the effectiveness among herbal formulation and a commonly available(3). Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated with herbal products attributed with weight-reducing properties(4)(5)(6)(7). The College of Medicine, The Ohio State University insisted that various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.

The serum level of vitamin D
Low levels of micronutrients, including vitamin D are most common among overweight and obese children. According to the study, low serum 25-hydroxyvitamin D3 (25(OH)D) levels not only is associated to insulin resistance and cardiovascular diseases risks(9) but also incidence of obesity(10).
The study of Suspected Nonalcoholic Fatty Liver Disease in Chinese AmericanChildren also supported the link of obesity and metabolic syndrome among Chinese American childrenand suggested that testing for metabolic disorders and low vitamin D levels would be necessary to identify the early indication of NAFLD in childhood will allow for intervention with lifestyle modification, providing a means to reduce the prevalence of NAFLD in children and adults(11).
DR, Peterson CA, and Dr. Belenchia AM. told PubMed "There is a well-established inverse relationship between vitamin D status and obesity; however, it is unknown as to whether vitamin D deficiency contributes to, or is a consequence of obesity"(12). Some researchers suggested that correction of poor vitamin Dstatus through dietary supplementation may be an effective addition to the standard treatment of obesity and its associated insulin resistance(13) as vitamin D deficiency is accounted for the secular trends in the prevalence of obesity and for individual differences in its onset and severity(14).

Vitamin D and adiponectin
A suggestion of association of low levels of Vitamin D and adiponectin is associated to obesity instead of vitamin D itself(15).
Adiponectin is a protein involved in regulating glucose levels as well as fatty acid breakdown.
According to the study by the Università del Piemonte Orientale, in the confirmation Adiponectin tight association with obesity and diabetes mellitus, suggested that multimeric adiponectin may be a key plasma protein that links vitamin D deficiency to pediatric obesity(16).
In support the link between Vitamin D and adiponectin and obesity, the Ramathibodi Hospital, Mahidol University study showed that circulating adiponectin appears to be inversely related to beta cell dysfunction in addition to insulin resistance only in obese women(17). Other in the study insisted that since low serum levels of 1α,25-dihydroxycholecalciferol (DHCC) attenuates (monocyte chemotactic protein-1)MCP-1 and adiponectin production in human adipocytes, thereby reducing the expression of both pro- and anti-inflammatory factors may explain the difficulties so far in determining the role of DHCC in insulin sensitivity and obesity in human(18).

Taken altogether, low serum levels of vitamin D and vitamin D deficiency are associated to increase risk of obesity and obese complications through involvement of vary mechanisms. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

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References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight lossand improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(9) The association of vitamin D status with cardiometabolic risk factors, obesityand puberty in children by Aypak C1, Türedi O, Yüce A.(PubMed)
(10) Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents by Garanty-Bogacka B1, Syrenicz M, Goral J, Krupa B, Syrenicz J, Walczak M, Syrenicz A.(PubMed)
(11) Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese American Children by Malespin M1, Sleesman B, Lau A, Wong SS, Cotler SJ.(PubMed)
(12) Vitamin D deficiency & childhood obesity: a tale of two epidemics by Peterson CA, Belenchia AM.(PubMed)
(13) Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial by Belenchia AM1, Tosh AK, Hillman LS, Peterson CA.(PubMed)
(14) Vitamin D deficiency is the cause of common obesity by Foss YJ.(PubMed)
(15) Cardiometabolic risk factors related to vitamin d and adiponectin in obese children and adolescents by Kardas F1, Kendirci M, Kurtoglu S.(PubMed)
(16) Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions by Walker GE1, Ricotti R2, Roccio M1, Moia S1, Bellone S2, Prodam F2, Bona G2.(PubMed)
(17) Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women by Chailurkit LO1, Chanprasertyothin S, Jongjaroenprasert W, Ongphiphadhanakul B.(PubMed)
(18) Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 andadiponectin production in human white adipocytes by Lorente-Cebrián S1, Eriksson A, Dunlop T, Mejhert N, Dahlman I, Aström G, Sjölin E, Wåhlén K, Carlberg C, Laurencikiene J, Hedén P, Arner P, Rydén M.(PubMed)

The #CurableSmoothie of Green Tea, Grape and Flax seed for Prevention and Treatment of Interstitial nephritis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Interstitial nephritis
Yield: 2 servings (about 8 ounces each)
1/4 cup flax seed
1 1/2 cups grape
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Interstitial nephritis (or tubulo-interstitial nephritis) is a form of (inflammation)nephritis, affecting the interstitium(space between) of the kidneys surrounding the tubules

The finding the natural ingredients for treatment of Interstitial nephritis is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Recent reports from numbers of well known institutions insisted, intake of flax seed(1), green tea(3) and grape(6)may be the next generation ingredient to be used on prevention and treatment of Interstitial nephritis. According to the University of Manitoba, dietary flax seed ameliorated Han:SPRD-cy rat polycystic kidney disease through moderation of the associated chronic interstitial nephritis(1).
Dr. Banković-Calić N and Dr. Ogbori MR, Nicman E. said, " Dietary protein restriction slows progression in numerous animal models of renal diseases. Flax seed has also demonstrated useful anti-inflammatory properties in a number of animal models and human diseases"(2).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study by the University of Niš, green tea induced the regeneration after renal injury and inflammation induced by gentamicin may be beneficial in the reduction of oxidative stress and changes caused by it primarily in renal tubules and interstitium(3) through improvement of antioxidant defense, tissue integrity and energy metabolism(4).
Furthermore, its phytochemical Epigallocatechin gallate (EGCG), may represent a potential strategy to reduce renal I/R injury induced inflammation by suppressing inflammation and cell apoptosis(5).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also consist anti Interstitial nephritis activity, through kidney protective effect against inflammation and oxidative stress(6).

The University of Houston joint study suggested, "Resveratrol treatment mitigated renal inflammation and injury" such as glomerulosclerosis, tubulointerstitial injury, infiltration of inflammatory cells" and "reduced oxidative stress, normalized antioxidant capacity"(7).

References
(1) Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease by Ogborn MR1, Nitschmann E, Weiler H, Leswick D, Bankovic-Calic N.(PubMed)
(2) [Effect of a modified low protein and low fat diet on histologic changes and metabolism in kidneys in an experimental model of polycystic kidney disease].[Article in Serbian] by Banković-Calić N1, Ogbori MR, Nicman E.(PubMed)
(3) Morphological and morphometric study of protective effect of green tea in gentamicin-induced nephrotoxicity in rats by Veljković M1, Pavlović DR2, Stojiljković N3, Ilić S3, Petrović A4, Jovanović I5, Radenković M3.(PubMed)
(4) Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney by Khan SA1, Priyamvada S, Farooq N, Khan S, Khan MW, Yusufi AN.(PubMed)
(5) Protective effect of epigallocatechin gallate, a major constituent of green tea, against renal ischemia-reperfusion injury in rats by Lv J1, Feng M, Zhang L, Wan X, Zeng YC, Liang PF, Xu AP.(PubMed)
(6) Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renalinflammatory cytokines via Nrf2-Keap1 signaling by Palsamy P1, Subramanian S.(PubMed)
(7) Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats by Javkhedkar AA1, Quiroz Y2, Rodriguez-Iturbe B2, Vaziri ND3, Lokhandwala MF1, Banday AA4.(PubMed)

All About #CurableVitamins: The effect of Vitamin D on Cervical Cancer

The Effect of Vitamin D on Cervical Cancer

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).

The Medical Center Bonn Friedensplatz, study showed a preferential risk factor of cancer in patient with low levels of concentration of serum vitamin D, including cervix carcinoma(1). 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), a biologically active metabolite of vitamin D, showed to regulate the growth of various cell types. The expression of VDR, 25-OHase, 1alpha-OHase, and 24-OHase in breast carcinomas (BC), ovarian cancer (OC), cervix carcinomas (CC) might have the ability to synthesize 1alpha,25(OH)2D3 within the cells. Locally in regulating the proliferation and differentiation of the tissues(2). In the study of the same, 25(OH)D3-1alpha-hydroxylase have shown to express in normal cervical tissue, incervical cancer and in HeLa cells. This local synthesization of 1alpha, 25(OH)2D3 may be significant importance in the regulation of growth control in normal and malignant cervical tissue(3).
In human epithelioid carcinoma cells of cervix HeLa S3K, vitamins D3-induced alkaline phosphatase activity in malignant cells(4).
In a selected 405 incident cervical neoplasias (333 invasive carcinomas and 72cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls in Japanese women showed an inverse correction between dietary calcium and vitamin D intake and cervical neoplasia risk(5).

Taken together, decreased serum of vitamin D might be associated to reduced risk of cervical cancer. Receptor of vitamin D and its active metabolite of vitamin D may be used to regulation of the cervical cancer tissues. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

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Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html

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References
(1) Circulating 25-hydroxyvitamin D concentration in German cancer patients by Reinhold U1, Schmitz B, Kurbacher C, Nagel W, Schmidt M, Malaisse WJ.(PubMed)
(2) Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer by Friedrich M1, Rafi L, Mitschele T, Tilgen W, Schmidt W, Reichrath J.(PubMed)
(3) Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in cervical tissue by Friedrich M1, Villena-Heinsen C, Axt-Fliedner R, Meyberg R, Tilgen W, Schmidt W, Reichrath J.(PubMed)
(4) Effect of vitamin D3 and 1,25(OH)2D3 on growth of neoplastically derived cell lines and their alkaline phosphatase activity by Kholodova YuD1, Bondar OP, Melnykovych G.(PubMed)

(5) Association between dietary calcium and vitamin D intake and cervicalcarcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)

The Curable Smoothies