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Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about. In fact, it happens. Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).
The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.
The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.
The smoothie for Prevention and treatment of Danubian endemic nephropathy
Yield: 2 servings (about 8 ounces each)
1 1/2 cups grape
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
Recent studies by some renowned institutions suggested that green tea(1) and grape may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of Danubian endemic nephropathy.
Balkan endemic nephropathy is a form of progression kidney damage induced kidney failure, affecting people only in Croatia, Bosnia and Herzegovina, Serbia, Romania and Bulgaria. According to the pubication by Richmond County Medical Society " Balkan endemic nephropathy is rare, chronic kidney disease"(*) of that may share some characteristics of normal chronic kidney disease in induction of kidney failure.
The smoothie for prevention and treatment of Chronic Kidney disease in Danubian endemic nephropathy
Yield: 2 servings (about 8 ounces each)
1/2 cup olive
1 cup cooked sweet potato
1 cup organic grape juice
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Chronic Kidney disease in Danubian endemic nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Chronic Kidney disease in patients with Danubian endemic nephropathy
Chronic Kidney Diseases(CKD) is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).
The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).
N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat
modification in CKD patients, according to the Karolinska Institutet(5).
Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).
Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).
According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9). Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients.
The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Chronic Kidney disease in Conorenal syndrome with little or no adverse effects.
People who are at high risk of Kidney disease in Conorenal syndrome should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.
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References
(*) Balkan endemic nephropathy is rare, chronic kidney disease by Richmond County Medical Society
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)
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