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Tuesday, April 19, 2016

All About #CurableVitamins: The effects of Vitamin C on Cervical Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamins are organic compounds and vital nutrients needed by your body to grow and develop in a profound way.

Vitamin C
Vitamin C, also known as L-ascorbate is a water soluble vitamin with a chemical structure formula of C6H6O6 and cannot be stored in the body for more than 24 hours. It is also best known for it's antioxidant property in strengthening the immune system.

               The Effect of Vitamin C on Cervical Cancer

Vitamin C, \ found in fresh fruits, berries and green vegetables, is best known for its free radical scavengers activity and regenerated oxidized vitamin E for immune support.
Epidemiological studies linking vitamin C in reduced risk of cervical cancer may be inconclusive(1)(1c)(1a)(1b), but no doubt in acceptance of improved quality of life(QoL)(2).

Cervix is the lower part of uterus that opens at the top of the vagina. Cervix acts an transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignantneoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

D-Glucopyranosyl-L-ascorbic acid (AA-2βG), a novel stable vitamin C analog isolated from Lycium barbarum fruit induced Hela cell apoptosis through cell cycle arrest(3). A case-control study including 239 diagnosed with squamous cell carcinoma of the cervix and 979 hospital patients with nonneoplastic found a significant reductions in risk of approximately 40-60% observed for women in the highest vs. lowest tertiles of dietary intake, including vitanin C(4)(4a). In human cervical cancer CaCx patients of the age group of 25-65 years, oral administration of vitamin C reduced oxidative stress risk of CaCx with no side effect(5). A nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract inhibited 100% of invasion of human cervical cancer cells CCL-2 and DoTc2 4510 at 500 microg/mL NM, according to the study of Matthias Rath Research Institute(6).
The study at All India Institute of Medical Sciences of the effects of vitamin C incervical cancer patients, indicated that vitamin C downregulates the redox sensitive transcription factor AP-1 and decreases one of its transcription targets HPV E6, and stabilizes P53 through increase in Bax and decrease in Bcl-2 and telomerase activity(7). In deed, the study at Kidwai Memorial Institute of Oncology also found s significant low levels of of carotene, vitamin A, and vitamin C measured in the serum of patients with cancer of the uterine cervix(8).
Other researchers suggested malnutrition may be a significant cause for the increased prevalence of cervical cancer in women with evidences of low levels of GSH, GPx, GST, SOD, vitamin E and vitamin C in the circulation of cervical cancerpatient(9).

Taken altogether, oral administration of vitamin C may be associated to reduced risk and treatment of cervical cancer and precancer but malnutrition and nutrients deficiency may play an important role in enhancing the start of the cancer itself.Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(10)(11).

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(1) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1a) Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a meta-analysis by Myung SK1, Ju W, Kim SC, Kim H; Korean Meta-analysis (KORMA) Study Group.(PubMed)
(1b) Intakes of vitamin A, C, and E, and beta-carotene are associated with risk ofcervical cancer: a case-control study in Korea by Kim J1, Kim MK, Lee JK, Kim JH, Son SK, Song ES, Lee KB, Lee JP, Lee JM, Yun YM.(PubMed)
(1c) Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial by Lin J1, Cook NR, Albert C, Zaharris E, Gaziano JM, Van Denburgh M, Buring JE, Manson JE.(PubMed)
(2) [Effect of antioxidant supplementation over oxidative stress and quality of life incervical cancer].

[Article in Spanish] by Fuchs-Tarlovsky V1, Bejarano-Rosales M, Gutiérrez-Salmeán G, Casillas MA, López-Alvarenga JC, Ceballos-Reyes GM.(PubMed)
(3) Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L by Zhang Z1, Liu X, Wu T, Liu J, Zhang X, Yang X, Goodheart MJ, Engelhardt JF, Wang Y.(PubMed)
(4) Dietary intakes of selected nutrients and food groups and risk of cervical cancerby Ghosh C1, Baker JA, Moysich KB, Rivera R, Brasure JR, McCann SE.(PubMed)
(4a) Involvement of oxidative stress in the pre-malignant and malignant states ofcervical cancer in women by Gonçalves TL1, Erthal F, Corte CL, Müller LG, Piovezan CM, Nogueira CW, Rocha JB.(PubMed)
(5) Oxidative stress and antioxidant status in cervical cancer patients by Naidu MS1, Suryakar AN, Swami SC, Katkam RV, Kumbar KM.(PubMed)
(6) Suppression of human cervical cancer cell lines Hela and DoTc2 4510 by a mixture of lysine, proline, ascorbic acid, and green tea extract by Roomi MW1, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.(PubMed)
(7) Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53 by Reddy VG1, Khanna N, Singh N.(PubMed)
(8) Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix by Ramaswamy G1, Krishnamoorthy L.(PubMed)
(9) Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case-control study by Manju V1, Kalaivani Sailaja J, Nalini N.(PubMed)

(10) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(11) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)

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