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Wednesday, July 26, 2017

All About Vitamins: Thiamine in Reduced Risk of Complications and Treatment of Type II diabetes

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Diabetes is a condition caused by insufficient insulin entering the bloodstream in regulating the glucose. The disease is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Thiamine therapy induced a significant change of protein functions in reduced symptoms and complications in patients with Type II diabetes, a study by renowned Institute suggested.

In a double-blind, randomised trial, where 12 hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes mellitus) received both placebo and thiamine capsules (3 × 100 mg/day) for six weeks in a cross-over manner, high dosed vitamin group showed a significant effects on the blood pressure of individuals with hyperglycemia at early stages, and prevention of vascular complications.

Furthermore,  high-dose thiamine supplementation also displayed an impact on glucose tolerance in patients with impaired glucose metabolism.

Dr. Alaei Shahmiri F, the lead researcher on the study said, " supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation"

Further study also suggested that increase supplement intake may reduce risk thiamine deficiency in the diabetic population and ameliorate the early sign of diabetic kidney disease and improve lipid profile.

Taking altogether, intake of thiamine should have a potential effect in reduced risk of complications and treatment of Type II diabetic patients, pending to further studies.

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(1) Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 by Riaz S1.(PubMed)
(2) The impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trial by Alaei-Shahmiri F1, Soares MJ2, Zhao Y2, Sherriff J2.(PubMed)

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