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Sunday, July 2, 2017

All About Vitamins: Vitamin A Immunomodulatory Effects

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Vitamin A is found to associate to immune defence against the invasion of microorganisms, such as virus, through activation of inflammatory effects. According to the joint study lead by the Turku University Hospital, Detection of viruses decreased by age. Higher vitamin A levels showed borderline significance with less viral detection (P = 0.056).
Inflammation (from Latin inflammatio) is an immune response biological body tissues against harmful stimuli, such as pathogens, damaged cells, or irritants, ..

In Human Monocytes during Infection, vitamin A showed an unexpected ability to counteract the pathogen-induced transcriptional responses, through immunomodulatory activity, deepening on the inflammatory stimulus.

In a total of 35 patients with chronic immune thrombocytopenia, who failed with standard dose corticosteroids and/or splenectomy, immunomodulatory therapy with all-trans retinoid acid (ATRA) expressed a significant changes of Treg cells to induce response.

In fact, all-trans retinoid acid (ATRA) exhibited Immunomodulatory Effects through inhibited pro inflammatory cytokine production.

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Sources
(1) The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response by Elenius V1, Palomares O2,3, Waris M4, Turunen R1, Puhakka T5,6, Rückert B2, Vuorinen T4, Allander T7, Vahlberg T8, Akdis M2, Camargo CA Jr9, Akdis CA2, Jartti T1.(PubMed)
(2) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection by Klassert TE1, Bräuer J1, Hölzer M2, Stock M1, Riege K2, Zubiría-Barrera C1, Müller MM1,3, Rummler S4, Skerka C5, Marz M2, Slevogt H1.(PubMed)
(3) Efficacy of immunomodulatory therapy with all-trans retinoid acid in adult patients with chronic immune thrombocytopenia by Dai L1, Zhang R1, Wang Z2, He Y3, Bai X1, Zhu M1, Yu Z1, Ruan CG1.(PubMed)
(4) Vitamin A induces inhibitory histone methylation modifications and down-regulates trained immunity in human monocytes by Arts RJ1, Blok BA1, van Crevel R1, Joosten LA1, Aaby P1, Benn CS1, Netea MG2.(PubMed)

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