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Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.
Intake of prescribed dose of vitamin B1 supplement may reduce risk of complications and mortality with patients with Wernicke-Korsakoff syndrome, a renowned institution study suggested.
Wernicke-Korsakoff syndrome, a thiamine (vitamin B1) deficiency disease may induce potentially debilitating and fatal condition.
According to the Colman Centre for Specialist Rehabilitation Services, the condition is often undiagnosis because of other predisposed factors such as misuse alcohol in interference to the early analysis of the symptoms of diseases.
In a total of Sixty-one patients included (51 with WE and 10 with KS). of patients with WE, 78% were men and age at diagnosis was 57 years (interquartile range (IQR): 49-66). with 23% percent fulfilled the classic WE triad in the study, 50% of patients would be expected to die within 8 years of WE episode and main causes of death included serious bacterial infections (44.5%) and cancer (33.3%).
The joint study also emphasize that since the survival rate of of patients with an alcohol-related Wernicke-Korsakoff syndrome is poor, and treatment of alcohol abuse and early diagnosis of thiamine deficiency is a priority for improving clinical outcomes in prevention of of complications such as severe impairment of cognitive function and a craving for alcohol.
There is no doubt that vitamin B1 treatment in early diagnosis of Wernicke-Korsakoff syndrome in a priority in management of patients may be neccessary to reduced complications and motility.
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Sources
(1) Long-Term Mortality of Patients with an Alcohol-Related Wernicke-Korsakoff Syndrome by Sanvisens A1, Zuluaga P1, Fuster D1, Rivas I2, Tor J1, Marcos M3, Chamorro AJ3, Muga R1.(PubMed)
(2) Wernicke-Korsakoff syndrome: recognition and treatment by Donnelly A1.(PubMed)
(3)Repetitive Transcranial Magnetic Stimulation for Wernicke-Korsakoff Syndrome: A Case Report by Chung SW1, Park SW1, Seo YJ1, Kim JH1, Lee CH2, Lim JY1(PubMed)
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