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Tuesday, July 18, 2017

All About #CurableVitamins: Vitamin B1 deficiency in associated to Chronic Liver Failure

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Patient with chronic liver failure may be beneficiary for intake of prescribed quantity of vitamin B1 supplement depending to the stage of deficiency.

According to the Sanjay Gandhi Post Graduate Institute of Medical Sciences, patients with acute and acute-on-chronic liver failure of non-alcoholic etiology are assocaited to lower levels of blood thiamine.

In a study of 7 acute liver failure patients, blood thiamine showed significant positive correlation with mammillary bodies' volume only at the beginning. but follow-up study done after clinical recovery at 5 weeks., recovery patients showed a reversible restoration of blood thiamine level.

Dr. Butterworth RF said, " End-stage chronic liver failure results in thiamine deficiency caused principally by depletion of liver thiamine store" and "..... thiamine deficiency.... results in consequent increases in brain lactate, oxidative/nitrosative stress,"

Furthermore, in chronic hepatitis B infection, thiamine administration was associated with reduction in aminotransferase levels which is an indication of healthy liver.

Taking together, vitamin B1 is no doubt to associate to patients with chronic liver failure, tratment with vitamin B1 can be only managed by related field specialist.

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(1) Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology by Gupta RK1, Yadav SK, Saraswat VA, Rangan M, Srivastava A, Yadav A, Trivedi R, Yachha SK, Rathore RK.(PubMed)
(2) Thiamine deficiency-related brain dysfunction in chronic liver failure by Butterworth RF1.(PubMed)
(3) Thiamine treatment of chronic hepatitis B infection by Wallace AE1, Weeks WB.(PubMed)

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