All About Vitamins: Vitamin A and Stroke

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Retinoic acid (RA), a derivative of vitamin A plays crucial roles during vertebrate organogenesis in participated in blood-brain barrier (BBB) development in maintaining a stabilized milieu for synaptic and neuronal functions to prevent ischemic stroke.

Stroke is caused by uncontrolled diet that is high in saturated and trans fats resulting in cholesterol build up in the arteries and high blood pressure. In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, resulting in some cells in the brain to die off and are unable reproduce, then we have stroke. Other strokes happen when a blood vessel in the brain ruptures causing the cells in your brain to be deprived of oxygen in your blood, they die and never come back.

In a total of 60 male Kunming mice randomly divided into two groups, i.e. pretreatment (n=40) and post-treatment (n=20) groups, ATRA administered before transient middle cerebral artery occlusion (tMCAO)for 7 days mice group failed to protect brain against ischemic damage and ATRA administered mice group immediately following tMCAO induced cerebral protective effect 24 hours after tMCAO.

In cerebral ischemia-reperfusion injury mice, Dr. said, "Electroacupuncture (EA) decreased the infarct volume, promoted neurological functional recovery and increased the RA in transferred DNA information into mRNA and protein expression, compared with the model group" and "....promoting neurological functional recovery by modulating RA expression in the post-ischemic brain is one of the mechanisms by which EA can be effective in the treatment of ischemic stroke."

Please note the Retinoic acid receptor can be activated by both all-trans retinoic acid and 9-cis retinal acid.

Vitamin A deficiency may interfere with the function of stabilized milieu for synaptic and neuronal functions to induce stroke, as well as reduced cerebral protection against ischemic damage.

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Sources
(1) Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats by Kong L1, Wang Y1, Wang XJ1, Wang XT1, Zhao Y1, Wang LM2, Chen ZY3.(PubMed)
(2) [Effect of all-trans retinoic acid on cerebral ischemia injury and regulatory T cell accounts in stroke mice].[Article in Chinese]by Yang Y1, Wang S1, Jia W1, Dong H1, Wang C1.(PubMed)
(3) Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury by Hong J1, Wu G, Zou Y, Tao J, Chen L.(PubMed)