All About Vitamins: Vitamin A Interactions

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

All-trans retinoic acid (ATRA) played essential roles in the normal biological processes and the treatment of cancer and skin diseases may cause potential interaction with lysozyme, tyrosine, tryptophan and many antioxidants, such as curcumin (Cur), vitamin C (VC) and gallic acid (GA), according to the Tongji University study.

Coadministered with ketoconazole and liarozole, atRA expressed favorably in regulating the cell cycle, and the treatment of other cancers against therapy resistance, inhibitors of atRA metabolism.
Dr. Jing J. the lead author said, "It accurately predicted the changes in atRA exposure after continuous dosing and when coadministered with ketoconazole and liarozole. The developed model will be useful in interpretation of atRA disposition and efficacy, design of novel dosing strategies, and development of next-generation atRA metabolism inhibitors".

In B-cell chronic lymphocytic leukemia cells, combination of ATRA and rituximab showed synergistic induction of apoptosis compared to untreated CLL cells as a negative control.

Taking altogether, Intake and Vitamin A may increase the efficacy of other vitamins and herbs in reduced production of free radicals. When used combination with other conventional medicines, vitamin A induced the effectiveness and expression of medicines involved.

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Sources
(1) Interaction of retinoic acid radical cation with lysozyme and antioxidants: laser flash photolysis study in microemulsion by Li K1, Wang M, Wang T, Sun D, Zhu R, Sun X, Wu X, Wang SL.(PubMed)
(2) Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions by Jing J1, Nelson C1, Paik J1, Shirasaka Y1, Amory JK1, Isoherranen N2.(PubMed)
(3) Synergistic induction of apoptosis in B-cell chronic lymphocytic leukemia cells after treatment with all-trans retinoic acid in combination with interleukin-21 and rituximab by Abbaszadeh-Goudarzi K1, Shokri F2, Hosseini M3, Jadidi-Niaragh F2, Ghalamfarsa G4, Saboor-Yaraghi AA5.(PubMed).