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Tuesday, July 11, 2017

All About #CurableVitamins: The role of Carotenoids in age-related macular degeneration

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Recent study suggedted that intake  of lutein and zeaxanthin, members of arotenoids, supplements may have a beneficiary effect in reduced risk of age-related macular degeneration, through its antioxidant properties.

Carotenoids, included carotene, are the group of orange pigments phytochemical played an important role as precursors of vitamin A.

Macular degeneration is the small central area of the retina of the eye that controls visual acuity has been reduced due to aging.

In a total of 63,443 women and 38,603 men were followed up, from 1984 until May 31, 2010, in the Nurses' Health Study and from 1986 until January 31, 2010, in the Health Professionals Follow-up Study suggested, higher intake of bioavailable lutein/zeaxanthin is associated with a long-term reduced risk of advanced AMD, as risk of advanced AMD is reduced by about 40% in both women and men.

Intake of carotenoids was also associated with a 25% to 35% lower risk of advanced AMD when comparing extreme quintiles.
Dr. Wise J1. said," diet rich in carotenoids is linked to reduced risk of advanced age related macular degeneration"

In support of the above, Dr. Ma L, the lead researcher said, "Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR 0·74; 95 % CI 0·57, 0·97); and a statistically significant inverse association was observed between lutein and zeaxanthin intake and neovascular AMD risk (RR 0·68; 95 % CI 0·51, 0·92)" in review of the five databases up to April 2010.

In fact, Increased dietary intake of or supplementation with lutein and zeaxanthin was also found to increase plasma levels,  associated with macular pigment optical density, but optimal dose of lutein and zeaxanthin for the prevention or treatment of AMD has not yet been defined.

taking altogether, Carotenoids may be a potential supplement for reduecd risk and treatment of age-related macular degeneration, but quantity intake should be consulted with specific profession as toxicity has been recorded in case of overdoses.

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(1) Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular DegenerationDuring 2 Decades of Prospective Follow-up by Wu J1, Cho E2, Willett WC3, Sastry SM4, Schaumberg DA5.(PubMed)
(2) Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis by Ma L1, Dou HL, Wu YQ, Huang YM, Huang YB, Xu XR, Zou ZY, Lin XM.(PubMed)
(3) Lutein and zeaxanthin for macular degeneration by Zhao L1, Sweet BV.(PubMed)

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