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Monday, July 3, 2017

All About Vitamins: Vitamin A Antiproliferative Effects

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Novel all-trans-retinoic acid (ATRA), a derivative of vitamin A, according to the School of Pharmacy, Zunyi Medical University, efficiently triggered cell cycle arrest and induced apoptosis in cancer cell lines MKN-45 and BGC-823 cells. 
The Antiproliferative Effects is a result of increase the expression levels in regulated the retinoic acid receptor.

In human thyroid carcinoma cells, the derivative also increased its antiproliferative properties through liposomes, a artificial formation which protects (ATRA) against photodegradation.

The joint study of the effect of The NSCLC cell lines A549, NCI-H460 and HCC827 treated with ATRA, lead by the University of Freiburg Medical Center, ingestion of ATRA alone reduced cellular proliferation by at least 50 %, particular in the A549, lung cancer cell line.

In fact, the antiproliferative effects of all-trans-retinoic acid (ATRA) has shown a significant anti-proliferative and anti-migration effect upon melanoma cells without inducing toxicity, when used conjunction with endoxifen.

Taking altogether, vitamin A derivative may be a potential agent for treatment of varies cancers, but further studies in human trial are necessary to ensure the safety of the future application.

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Sources
(1)Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells by Zhang L1, Wang J2, Liu L3, Zheng C4, Wang Y5.(PubMed)
(2) Anticancer activity of all-trans retinoic acid-loaded liposomes on human thyroid carcinoma cells by Cristiano MC1, Cosco D2, Celia C3, Tudose A4, Mare R1, Paolino D5, Fresta M6.(PubMed)
(3) Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid by Greve G1,2, Schiffmann I3,4, Lübbert M5,6.(PubMed)
(4) The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells by Ribeiro MP1, Silva FS, Paixão J, Santos AE, Custódio JB.(PubMed)

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